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Cited by 496Iron Metabolism and DisordersAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH

Bekri, Soumeya, Gual, Philippe, Anty, Rodolphe, Luciani, Nathalie, Dahman, Monsef, Ramesh, Bala, Iannelli, Antonio, Staccini–Myx, Aline, Casanova, Dominique, Ben Amor, Imed, Saint–Paul, Marie–Christine, Huet, Pierre–Michel, Sadoul, Jean–Louis, Gugenheim, Jean, Srai, Surjit Kaila S., Tran, Albert, Le Marchand–Brustel, Yannick·2006·Gastroenterology
DOI 10.1053/j.gastro.2006.07.007
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Abstract

Backgrounds & aims Hepcidin is an acute-phase response peptide. We have investigated the possible involvement of hepcidin in massive obesity, a state of chronic low-grade inflammation. Three groups of severely obese patients with or without diabetes or nonalcoholic steatohepatitis were investigated.Methods Hepcidin expression was studied in liver and adipose tissue of these patients. Hepcidin regulation was investigated in vitro by adipose tissue explant stimulation studies.Results Hepcidin was expressed not only in the liver but also at the messenger RNA (mRNA) and the protein levels in adipose tissue. Moreover, mRNA expression was increased in adipose tissue of obese patients. The presence of diabetes or NASH did not modify the hepcidin expression levels in liver and adipose tissue. In adipose tissue, mRNA expression correlated with indexes of inflammation, interleukin-6, and C-reactive protein. Interleukin-6 also promoted in vitro hepcidin expression. A low transferrin saturation ratio was observed in 68% of the obese patients; moreover, 24% of these patients presented with anemia. The observed changes in iron status could be due to the role of hepcidin as a negative regulator of intestinal iron absorption and macrophage iron efflux. Interestingly, a feedback control mechanism on hepcidin expression related to low transferrin saturation occurred in the liver but not in the adipose tissue.Conclusions Hepcidin is a proinflammatory adipokine and may play an important role in hypoferremia of inflammation in obese condition.

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Metadata

Authors
Bekri, S., Gual, P., Anty, R., Luciani, N., Dahman, M., Ramesh, B., Iannelli, A., Staccini–Myx, A., Casanova, D., Ben Amor, I., Saint–Paul, M., Huet, P., Sadoul, J., Gugenheim, J., Srai, S. K. S., Tran, A., & Le Marchand–Brustel, Y.
Affiliations
  • Université Nice Sophia Antipolis (FR)
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Nice (FR)
  • The Royal Free Hospital (GB)
  • Hôpital de la Conception (FR)
Corresponding author
  • Bekri, Soumeya
  • Gual, Philippe
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2006-09
Volume
131
Issue
3
Pages
788-796
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2006.07.007
OpenAlex
W2088475546
Cited by
496
References
46
Citations by year
2026: 9 · 2025: 14 · 2024: 15 · 2023: 17 · 2022: 23 · 2021: 18 · 2020: 29 · 2019: 16 · 2018: 23 · 2017: 26 · 2016: 27 · 2015: 39 · 2014: 38 · 2013: 41 · 2012: 26
FWCI
15.20
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
hepcidin, morbid obesity, adipose tissue, nonalcoholic steatohepatitis, diabetes mellitus, interleukin-6, C-reactive protein, low-grade inflammation, transferrin saturation, anemia of chronic disease, iron status, intestinal iron absorption, adipokines
MeSH terms
Adipose Tissue, Adult, Biopsy, C-Reactive Protein, Cell Line, Diabetes Mellitus, Fatty Liver, Female, Humans, Immunohistochemistry, Male, Middle Aged, Obesity, Morbid, RNA, Messenger, Severity of Illness Index, Transferrin, Interleukin-6, Gene Expression, Polymerase Chain Reaction, Antimicrobial Cationic Peptides, Hepcidins

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