STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo

A new mathematical model for relative quantification in real-time RT-PCR

Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

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A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

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Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load

Chatterjee, P., Mohammadi, M., Goozee, K. G., Shah, T. M., Sohrabi, H. R., Dias, C. B., Shen, K., Asih, P. R., Dave, P., Pedrini, S., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200162 · Cited by 14

Upstream stimulatory factor 2 is implicated in the progression of biliary atresia by regulation of hepcidin expression

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Huayu Jiedu Fang Protects Ovarian Function in Mouse with Endometriosis Iron Overload by Inhibiting Ferroptosis

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Pathogenic Mechanisms in Thalassemia II

Ganz, T., & Nemeth, E. (2023) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2022.12.006 · Cited by 17

Friend of GATA suppresses the GATA-induced transcription of hepcidin in hepatocytes through a GATA-regulatory element in the HAMP promoter

Bagu, E. T., & Santos, M. M. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0060 · Cited by 15

Iron and the Reticuloendothelial System

Weiß, G. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_11 · Cited by 13

Relationship between iron overload caused by abnormal hepcidin expression and liver disease: A review

Zheng, H., Yang, F., Deng, K., Wei, J., Liu, Z., Zheng, Y., & Xu, H. (2023) · Medicine · doi:10.1097/md.0000000000033225 · Cited by 12

Anti-mouse CD52 monoclonal antibody ameliorates iron-deficient anaemia in IL-10 knockout mice

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Fermented goat milk consumption improves iron status and evokes inflammatory signalling during anemia recovery

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Iron Metabolism and Disease

Sebastiani, G., & Pantopoulos, K. (2010) · CRC Press eBooks · doi:10.1201/9781420059984-c13 · Cited by 12

Chronic intermittent hypobaric hypoxia improves iron metabolism disorders via the IL-6/JAK2/STAT3 and Epo/STAT5/ERFE signaling pathways in metabolic syndrome rats

Cui, F., Sun, J. Y., Mi, H., Li, B., Tang, L., Wang, R., Du, Y., Guo, B., Li, Y., & Shi, M. (2023) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2023.127259 · Cited by 11

Serum-induced up-regulation of hepcidin expression involves the bone morphogenetic protein signaling pathway

Shanmugam, N. K. N., & Cherayil, B. J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.10.065 · Cited by 11

Longitudinal changes in iron homeostasis in human experimental and clinical malaria

Woolley, S., Grigg, M. J., Marquart, L., Gower, J. S. E., Piera, K. A., Nair, A. S., Amante, F. H., Rajahram, G. S., William, T., Frazer, D. M., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105189 · Cited by 11

Pharmacological Inhibition of Cyclin-Dependent Kinases Triggers Anti-Fibrotic Effects in Hepatic Stellate Cells In Vitro

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Iron metabolism in rheumatic diseases

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Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via targeting the hepcidin – ferroportin axis in mice with CCl₄-induced liver fibrosis

Badi, S. A., Aval, H. T., Moradi, H. R., Malek, A., Seyedi, S. A., Davari, M., Bereimipour, A., Khani, S., Khatami, S., & Siadat, S. D. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00728-x · Cited by 10

Iron-regulatory gene expression during liver regeneration

Mollbrink, A., Holmström, P., Sjöström, M., Hultcrantz, R. W., Eriksson, L. C., & Stal, P. I. (2012) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2012.661761 · Cited by 9

Correlation ofHAMPgene polymorphisms and expression with the susceptibility and length of hospital stays in Taiwanese children with Kawasaki disease

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Predicting gene-level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework

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Biting the Iron Bullet: Endoplasmic Reticulum Stress Adds the Pain of Hepcidin to Chronic Liver Disease

Messner, D. J., & Kowdley, K. V. (2010) · Hepatology · doi:10.1002/hep.23507 · Cited by 10

Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

Pidde, G., Nishiyama, M. Y., de Oliveira, Ú. C., Villas-Boas, I. M., Leme, A. F. P., Junqueira-de-Azevedo, I. L. M., Marques-Porto, R., Squaiella‐Baptistão, C. C., & Tambourgi, D. V. (2021) · Scientific Reports · doi:10.1038/s41598-020-79769-y · Cited by 9

Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia

Raha‐Chowdhury, R., Raha, A. A., Henderson, J. W., Ghaffari, S. D., Grigorova, M., Beresford‐Webb, J., Allinson, K. S. J., Chakraborty, S., Holland, A. J., & Zaman, S. H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132909 · Cited by 9

Allogeneic Transplantation, Fas Signaling, and Dysregulation of Hepcidin

Li, X., Xu, F., Karoopongse, E., Marcondes, A. M., Lee, K., Kowdley, K. V., Miao, C. H., Trobridge, G. D., Campbell, J. S., & Deeg, H. J. (2013) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2013.05.012 · Cited by 9

RGM Family Involved in the Regulation of Hepcidin Expression in Anemia of Chronic Disease

Fujii, T., Kobayashi, K., Kaneko, M., Osana, S., Tsai, C.-T., Ito, S., & Hata, K. (2024) · Immuno · doi:10.3390/immuno4030017 · Cited by 11

Oxidative Status, Iron Plasma Levels in Venous Thrombosis Patients

Signorelli, S. S., Barbagallo, A., Conti, G. O., Fiore, M., Cristaldi, A., & Ferrante, M. (2024) · Antioxidants · doi:10.3390/antiox13060689 · Cited by 8

Serum iron levels as a new biomarker in chemotherapy with leucovorin and fluorouracil plus oxaliplatin or leucovorin and fluorouracil plus irinotecan, with or without molecularly-targeted drugs

Ochiai, T., Nishimura, K., Watanabe, T., Kitajima, M., Nakatani, A., Inou, T., Shibata, H., Sato, T., Kishine, K., SEO, S., et al. (2013) · Molecular and Clinical Oncology · doi:10.3892/mco.2013.136 · Cited by 8

Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: a case report

Nishina, S., Tomiyama, Y., Ikuta, K., Tatsumi, Y., Toki, Y., Kato, A., Kato, K., Yoshioka, N., Sasaki, K., Hara, Y., et al. (2021) · BMC Gastroenterology · doi:10.1186/s12876-021-01674-z · Cited by 8

Disorders of iron overload

Paterson, A. C., & Pietrangelo, A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3398-8.00005-2 · Cited by 9

Hepcidin Regulation by Bone Morphogenetic Protein Signaling and Iron Homeostasis

Rodova, M., & Kim, S. (2016) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000521 · Cited by 7

Distribution and Associated Factors of Hepatic Iron—A Population-Based Imaging Study

Maier, L., von Krüchten, R., Lorbeer, R., Filler, J., Nattenmüller, J., Thorand, B., Köenig, W., Rathmann, W., Bamberg, F., Schlett, C. L., et al. (2021) · Metabolites · doi:10.3390/metabo11120871 · Cited by 9

Influence of Hepcidin in the Development of Anemia

Reichert, C. O., Marafon, F., Levy, D., Maselli, L. M. F., Bagatini, M. D., Blatt, S. L., Bydlowski, S. P., & Spada, C. (2018) · InTech eBooks · doi:10.5772/intechopen.71476 · Cited by 8

A Recombinant Antibody Against ALK2 Promotes Tissue Iron Redistribution and Contributes to Anemia Resolution in a Mouse Model of Anemia of Inflammation

Wang, C., Melgar-Bermudez, E., Welch, D., Dagbay, K. B., Bhattacharya, S., Lema, E., Daman, T. H., Sierra, O., Todorova, R., Drame, P. M., et al. (2025) · American Journal of Hematology · doi:10.1002/ajh.27578 · Cited by 7

Prevalencia y características de la anemia en la enfermedad inflamatoria intestinal

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Metal Metabolism and Liver

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The α1‐adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway

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Iron chelation for the treatment of uveitis

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Emerging Role of SMILE in Liver Metabolism

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Hepcidin is elevated in mice injected with Mycoplasma arthritidis

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Disorders of Iron Overload

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Iron Metabolism and Related Disorders

Ginzburg, Y. Z., & Finberg, K. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-812535-9.00012-1 · Cited by 4

Tracking hepcidin level in induced type 2 diabetic rats and how Empagliflozin affects its level

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Hepcidin: SNP-Like Polymorphisms Present in Iron Metabolism and Clinical Complications of Iron Accumulation and Deficiency

Reichert, C. O., da Cunha, J., Levy, D., Maselli, L. M. F., Bydlowski, S. P., & Spada, C. (2017) · InTech eBooks · doi:10.5772/intechopen.69507 · Cited by 4

High serum hepcidin is associated with the occurrence of anemia in anti-myeloperoxidase antibody-associated vasculitis with normal kidney function: a cross-sectional study

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TAM-ing the CIA—Tumor-Associated Macrophages and Their Potential Role in Unintended Side Effects of Therapeutics for Cancer-Induced Anemia

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New alternatives for erythropoietin therapy in chronic renal failure

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TMPRSS6 rs855791 polymorphism is associated with iron deficiency in a cohort of Sri Lankan pregnant women

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Hepatic oxidative stress in ovariectomized transgenic mice expressing the hepatitis C virus polyprotein is augmented through suppression of adenosine monophosphate‐activated protein kinase/proliferator‐activated receptor gamma co‐activator 1 alpha signaling

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Iron Deficiency Anemia and Serum Hepcidin Level in Children with Typhoid Fever: A Case–Control Study

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The effects of reducing chronic inflammation in overweight women on serum hepcidin and iron absorption with and without supplemental ascorbic acid

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Molecular Regulation of Systemic Iron Metabolism

Ganz, T., & Vaulont, S. (2011) · Humana Press eBooks · doi:10.1007/978-1-60327-485-2_9 · Cited by 4

The Role of Hepcidin in Iron Homeostasis

Ganz, T. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-462-9_3 · Cited by 3

Differential diagnosis of anemia in pregnant women

Prokhorenko, T. S., Zima, A. P., Саприна, Т. В., Мусина, Н. Н., Shakhmanova, N. S., & Novitsky, V. V. (2017) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2017-1-140-151 · Cited by 2

Hepcidin: A multifaceted hormone in iron homeostasis and tumor biology

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The role of hepcidin and haemojuvelin in the pathogenesis of iron disorders in patients with severe malnutrition

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Disorders of Red Cell Production and the Iron-Loading Anemias

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Métabolisme du fer

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Hepcidin and the Hormonal Control of Iron Homeostasis

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Pathogenesis of anemia in pregnant women with gestational diabetes mellitus

Zima, A. P., Prokhorenko, T. S., Саприна, Т. В., Мусина, Н. Н., Novitsky, V. V., & Baykov, A. N. (2020) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2020-2-28-33 · Cited by 2

Predictive Value of Serum Hepcidin Levels for the Risk of Incident End-Stage Kidney Disease in Patients with Chronic Kidney Disease: The KNOW-CKD

Suh, S. H., Oh, T. R., Choi, H. S., Kim, C. S., Bae, E. H., Kwon, S. S., Oh, K., Lee, K., Jung, J. Y., Kim, S. W., et al. (2024) · Kidney Diseases · doi:10.1159/000542057 · Cited by 2

Prognostic value of serum C-reactive protein in idiopathic multicentric Castleman disease and construction of a prognostic model for patients

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Increased levels of systemic iron content in adult-onset interleukin-6 knockout mice

Zhang, F., Zhang, C., Luo, Q., Li, J., Qiu, X., & Qian, Z. (2025) · Redox Report · doi:10.1080/13510002.2025.2602306 · Cited by 1

Hepcidin Interplay in Regulating Iron Level at Liver, Intestine and Reticoendothelial System

Kumar, J. (2017) · Journal of Liver Research Disorders & Therapy · doi:10.15406/jlrdt.2017.03.00042

Influence of Physical Activity on the Regulation of Iron Metabolism

Zaitseva, I. P., Tinkov, A. A., & Skalny, A. V. (2018) · Human Physiology · doi:10.1134/s0362119718050158 · Cited by 2

Hemochromatosis

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Iron Overload-Induced Hepatotoxicity: An Overview

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Tocilizumab, a Humanized Anti-interleukin-6 Receptor Antibody, Induces Hepatic Iron Overload in a Susceptible Patient

Harada, M., Honma, Y., Shiba, E., Tomosugi, N., & Harada, R. (2024) · Internal Medicine · doi:10.2169/internalmedicine.4329-24 · Cited by 5

Comprehensive Evaluation of Growth Performance, Hematological Parameters, Antioxidant Capacity, Innate Immunity, and Disease Resistance in Crucian Carp (Carassius auratus) Lacking Intermuscular Bones

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Iron metabolic disorder in chronic hepatitis C: insights from recent evidence

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Métabolisme du fer en 2012

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Apoptosis induced by Fas signaling does not alter hepatic hepcidin expression

Lu, S. (2014) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v5.i3.387 · Cited by 1

Liver Cirrhosis with Inherited Liver Disease: Hemochromatosis

Hino, K., & Nishina, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-7979-6_4 · Cited by 1

Disorders of Iron Overload

Pietrangelo, A., & Torbenson, M. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-8228-3.00004-1 · Cited by 1

Hepcidin and iron

Vecchi, C., & Pietrangelo, A. (2015) · Wiley eBooks · doi:10.1002/9781118663387.ch29 · Cited by 1

A Glimpse of Future Hepatitis C Virus Treatment Paradigms

Terrault, N. A., & Khalili, M. (2010) · Hepatology · doi:10.1002/hep.23523 · Cited by 1

Hfe-associated steatohepatitis: expression profiling and identifying the molecular basis of liver injury

Santrampurwala, N. (2016) · The University of Queensland · doi:10.14264/uql.2016.365 · Cited by 1

Effect of Hepcidin and Iron Deficiency Anemia on Clinical Outcome in patients with Kawasaki DiseasePreprint

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Longitudinal changes in iron homeostasis in human experimental and clinical malariaPreprint

Woolley, S., Grigg, M. J., Marquart, L., Gower, J. S. E., Piera, K. A., Nair, A. S., Amante, F. H., Rajahram, G. S., William, T., Frazer, D. M., et al. (2023) · medRxiv · doi:10.1101/2023.12.19.23300265 · Cited by 1

The Intricate Role of Adipokines in Immune-Mediated Diseases

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Anemia of the Critically Ill Patient: Pathophysiology, Lessons from Animal Models

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Prohepcidin and Hepcidin in Acute Phase Reaction Accompanying Large Cardiac Surgery

Maruna, P., Vokurka, M., & Lindner, J. (2012) · InTech eBooks · doi:10.5772/22324

Leituras Críticas: Gersão, T. (2024). Autobiografia não escrita de Martha Freud. Porto Editora. Lisboa. 414 pp.

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