The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
STAT3 Is Required for IL-6-gp130–Dependent Activation of Hepcidin In Vivo
Open accessAbstract
Background & aims Hepcidin is a peptide hormone that is central to the regulation of iron homeostasis. In response to interleukin 6 (IL-6), hepatocytes produce hepcidin that decreases iron release/transfer from enterocytes and macrophages and causes hypoferremia. To clarify the molecular pathways involved in hepcidin activation by IL-6, we used different mice strains in which the main IL-6/gp130 signaling pathways have been genetically disrupted. Methods We generated mice with hepatocyte-specific deletion of the IL-6 signal-transducing gp130 receptor (alfpgp130 (LoxP/LoxP)), with a gp130 receptor lacking the essential region for STAT1 and -3 activation (alfpCre gp130(DeltaSTAT/LoxP)) or mice expressing a gp130 allele lacking the essential tyrosine for RAS-MAPK activation (alfpCregp130(Y757F/LoxP)). We studied gp130-dependent pathways and hepcidin mRNA expression by Western blot, reverse-transcription polymerase chain reaction, and Northern blot in vivo and ex vivo. Results IL-6 stimulated phospho STAT3, serum amyloid A (SAA), and suppressor of cytokine signaling 3 (SOCS3) expression in livers of wild-type and alfpCregp130(Y757F/LoxP) mice, whereas this response was blocked in alfpCre gp130(LoxP/LoxP) and alfpCre gp130(DeltaSTAT/LoxP) mice. In wild-type and alfpCregp130(Y757F/LoxP) animals, significantly higher hepcidin mRNA expression was found 3 to 6 hours after IL-6 stimulation. In contrast, no IL-6-dependent regulation of hepcidin mRNA expression was found in alfpgp130 (DeltaSTAT/LoxP) and AlfpCre gp130 (LoxP/LoxP) animals. In primary hepatocytes, higher hepcidin mRNA expression after IL-6 stimulation was only observed when gp130-STAT3-dependent signaling was intact. Conclusions We have demonstrated that both in vivo and in vitro STAT3 is the key transcription factor responsible for IL-6 activation of hepcidin gene expression in the liver.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“IL-6 mediates these effects directly because it activates STAT3 to bind e.g. to the HAMP promoter, thus stimulating HAMP expression (Pietrangelo et al., 2007;Wrighting and Andrews, 2006).”
From Iron in infection and immunity (2020) · cites this paper as Pietrangelo et al., 2007
Experimental — accuracy not yet measuredIn the citing paper
“IL-6 is increased early in most microbial infections and it stimulates hepcidin transcription via the JAK2–STAT3 pathway in a manner dependent on STAT3-binding motifs in the promoter of HAMP (the hepcidin gene)89–91.”
From Iron homeostasis in host defence and inflammation (2015) · cites this paper as [91]
In the citing paper
“STAT3 is another positive effector of hepcidin expression [347,348], and ROSs inhibit this effect [349], thereby creating a link between ROSs and Fe metabolism.”
In the citing paper
“The inflammatory increase in hepcidin is mainly caused by increased concentrations of IL-6 (interleukin-6) [19], inducing the transcription of the hepcidin gene through the JAK2/STAT3 [20][21][22] pathway.”
From Iron and infection (2018) · cites this paper as [20]
In the citing paper
“In nonintestinal cells, circulating iron is bound to transferrin (Tf) and is imported via receptor-mediated endocytosis after binding to the transferrin receptor (TfR) (249).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [249]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Cleveland, D. W., Lopata, M. A., MacDonald, R. J., Cowan, N. J., Rutter, W. J., & Kirschner, M. W. (1980) · Cell · doi:10.1016/0092-8674(80)90238-x · Cited by 1,835
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233
Flagged first, then by citations
1 of the 43 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 315
Fatih, N., Camberlein, E., Island, M. L., Corlu, A., Abgueguen, E., Détivaud, L., Leroyer, P., Brissot, P., & Loréal, O. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-009-0588-3 · Cited by 59
Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice
Sebastiani, G., & Pantopoulos, K. (2011) · Metallomics · doi:10.1039/c1mt00082a · Cited by 58
Shanmugam, N. K. N., Chen, K., & Cherayil, B. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.689190 · Cited by 57
Chapter 6 Iron Homeostasis and Erythropoiesis
Wrighting, D. M., & Andrews, N. C. (2008) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(07)00006-3 · Cited by 59
Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus
Liu, H., Trinh, T. L., Dong, H., Keith, R., Nelson, D. R., & Liu, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046631 · Cited by 53
Kuo, H., Yang, Y.-L., Chuang, J. H., Tiao, M., Yu, H., Huang, L., Yang, K. D., Chang, W., Lee, C.-P., & Huang, Y. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9668-1 · Cited by 51
Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone
Chung, B., Verdier, F., Matak, P., Deschemin, J., Mayeux, P., & Vaulont, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-152561 · Cited by 51
Hu, W., Nevzorova, Y. A., Haas, U., Moro, N., Siciński, P., Geng, Y., Barbacid, M., Trautwein, C., & Liedtke, C. (2013) · Hepatology · doi:10.1002/hep.26584 · Cited by 51
Self-citationSTAT3 signaling within hepatocytes is required for anemia of inflammation in vivo
Sakamori, R., Takehara, T., Tatsumi, T., Shigekawa, M., Hikita, H., Hiramatsu, N., Kanto, T., & Hayashi, N. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0159-y · Cited by 49
Yun, S., & Vincelette, N. D. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.02.006 · Cited by 52
Iron and inflammation – the gut reaction
Verma, S., & Cherayil, B. J. (2017) · Metallomics · doi:10.1039/c6mt00282j · Cited by 51
Shanmugam, N. K. N., Trebicka, E., Fu, L.-L., Shi, H. N., & Cherayil, B. J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400278 · Cited by 49
Function of the hemochromatosis protein HFE: Lessons from animal models
Pantopoulos, K. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6893 · Cited by 49
Ryan, J. D., Altamura, S., Devitt, E. J., Mullins, S., Lawless, M. W., Muckenthaler, M. U., & Crowe, J. (2012) · Hepatology · doi:10.1002/hep.25666 · Cited by 49
Hepatic HDAC3 Regulates Systemic Iron Homeostasis and Ferroptosis via the Hippo Signaling Pathway
Meng, H., Yu, Y., Xie, E., Wu, Q., Yin, X., Zhao, B., Min, J., & Wang, F. (2023) · Research · doi:10.34133/research.0281 · Cited by 47
Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration
Dierssen, U., Beraza, N., Lutz, H. H., Liedtke, C., Ernst, M., Wasmuth, H. E., & Trautwein, C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m705483200 · Cited by 48
Self-citationHepcidin assay in serum by SELDI-TOF-MS and other approaches
Castagna, A., Campostrini, N., Zaninotto, F., & Girelli, D. (2009) · Journal of Proteomics · doi:10.1016/j.jprot.2009.08.003 · Cited by 49
Identifying genetic hypomethylation and upregulation of toll-like receptors in Kawasaki disease
Huang, Y., Li, S., Huang, L., Chen, P.-C., Lin, Y.-Y., Lin, C.-C., & Kuo, H. (2017) · Oncotarget · doi:10.18632/oncotarget.14497 · Cited by 48
Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes
Charlebois, E., & Pantopoulos, K. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253475 · Cited by 51
Mitochondrial damage and iron metabolic dysregulation in hepatitis C virus infection
Hino, K., Nishina, S., Sasaki, K., & Hara, Y. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.044 · Cited by 49
Pap, R., Pandur, E., Jánosa, G., Sipos, K., Nagy, T., Agócs, A., & Deli, J. (2022) · Antioxidants · doi:10.3390/antiox11112269 · Cited by 48
Non-HFE hemochromatosis: Pathophysiological and diagnostic aspects
Bardou‐Jacquet, E., Ali, Z. B., Beaumont-Epinette, M.-P., Loréal, O., Jouanolle, A., & Brissot, P. (2013) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2013.11.003 · Cited by 47
ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis
An, J., Mehrhof, F. B., Harms, C., Lättig-Tünnemann, G., Lee, S. L. L., Endres, M., Li, M., Sellge, G., Mandić, A. D., Trautwein, C., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.10.002 · Cited by 45
Self-citationEnculescu, M., Metzendorf, C., Sparla, R., Hahnel, M. J., Bode, J. G., Muckenthaler, M. U., & Legewie, S. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005322 · Cited by 46
Czaja, A. J. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15173 · Cited by 47
An, J., Harms, C., Lättig-Tünnemann, G., Sellge, G., Mandić, A. D., Malato, Y., Heuser, A., Endres, M., Trautwein, C., & Donath, S. (2012) · Hepatology · doi:10.1002/hep.25697 · Cited by 44
Self-citationCystathionine β‐synthase is required for body iron homeostasis
Zhou, Y., Wu, X., Zhou, G., Mu, M., Zhang, F., Li, F., Qian, C., Du, F., Yung, W., Qian, Z., et al. (2017) · Hepatology · doi:10.1002/hep.29499 · Cited by 45
Handa, P., Maliken, B. D., Nelson, J. E., Hennessey, K. A., Vemulakonda, L. A., Morgan‐Stevenson, V., Dhillon, B. K., Gupta, R., Yeh, M. M., & Kowdley, K. V. (2016) · Annals of Hepatology · doi:10.5604/16652681.1226818 · Cited by 44
Regulating ferroportin‐1 and transferrin receptor‐1 expression: A novel function of hydrogen sulfide
Zhang, M., Yang, G., Zhou, Y., Qian, C., Mu, M., Ke, Y., & Qian, Z. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27431 · Cited by 41
Zhou, Y., Wang, Q., Yang, Q., Tang, J., Xu, C., Gai, D.-W., Chen, X., & Chen, J. (2018) · Virologica Sinica · doi:10.1007/s12250-018-0057-7 · Cited by 41
Nuhu, F., Seymour, A. L., & Bhandari, S. (2019) · Antioxidants · doi:10.3390/antiox8100498 · Cited by 39
Activated macrophages induce hepcidin expression in HuH7 hepatoma cells
Matak, P., Chaston, T. B., Chung, B., Srai, S. K., McKie, A. T., & Sharp, P. (2009) · Haematologica · doi:10.3324/haematol.2008.003400 · Cited by 40
Migita, K., Koga, T., Komori, A., Torigoshi, T., MAEDA, Y., Izumi, Y., Sato, J., Jiuchi, Y., Miyashita, T., Yamasaki, S., et al. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.101362 · Cited by 39
Hereditary hemochromatosis and transferrin receptor 2
Chen, J., & Enns, C. A. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.07.015 · Cited by 38
Iron metabolic disorder in chronic hepatitis C : Mechanisms and relevance to hepatocarcinogenesis
Hino, K., Nishina, S., & Hara, Y. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12243 · Cited by 35
Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B
Besson‐Fournier, C., Gineste, A., Latour, C., Gourbeyre, O., Meynard, D., Martín, P., Oswald, É., Coppin, H., & Roth, M. (2016) · Blood · doi:10.1182/blood-2016-10-748541 · Cited by 36
Hypoxia enhances H2O2-mediated upregulation of hepcidin: Evidence for NOX4-mediated iron regulation
da Silva, I. P., Rausch, V., Peccerella, T., Millonig, G., Seitz, H. K., & Mueller, S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.02.005 · Cited by 35
Hepcidin and Iron Metabolism in Experimental Liver Injury
Bloomer, S. A., & Brown, K. E. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.04.005 · Cited by 38
Shanmugam, N. K. N., Ellenbogen, S., Trebicka, E., Wang, L., Mukhopadhyay, S., Lacy‐Hulbert, A., Gallini, C. A., Garrett, W. S., & Cherayil, B. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038136 · Cited by 37
Hepcidin Activation During Inflammation: Make It STAT
Fleming, R. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.049 · Cited by 36
Mouse Models of Anemia of Cancer
Kim, A., Rivera, S., Shprung, D., Limbrick, D., Gabayan, V., Nemeth, E., & Ganz, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093283 · Cited by 35
Kartikasari, A. E. R., Roelofs, R., Schaeps, R. M. J., Kemna, E., Peters, W. H. M., Swinkels, D. W., & Tjalsma, H. (2008) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2008.08.004 · Cited by 35
HAMP promoter hypomethylation and increased hepcidin levels as biomarkers for Kawasaki disease
Huang, Y., Kuo, H., Li, S.-C., Cai, X.-Y., Liu, S., & Kuo, H. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.02.017 · Cited by 34
Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi
Koening, C. L., Miller, J. C., Nelson, J. M., Ward, D. M., Kushner, J. P., Bockenstedt, L. K., Weis, J. J., Kaplan, J., & Domenico, I. D. (2009) · Blood · doi:10.1182/blood-2009-03-209577 · Cited by 32
The SMAD Pathway Is Required for Hepcidin Response During Endoplasmic Reticulum Stress
Canali, S., Vecchi, C., Garuti, C., Montosi, G., Babitt, J. L., & Pietrangelo, A. (2016) · Endocrinology · doi:10.1210/en.2016-1258 · Cited by 33
Self-citationTruksa, J., Lee, P. L., & Beutler, E. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.06.014 · Cited by 33
Regulation of Iron Absorption in Hemoglobinopathies
Rechavi, G., & Rivella, S. (2008) · Current Molecular Medicine · doi:10.2174/156652408786241401 · Cited by 32
Iron metabolism in colorectal cancer
Huang, L., Li, W., Lu, Y., Ju, Q., & Ouyang, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1098501 · Cited by 34
Li, W.-Y., Li, F.-M., Zhou, Y., Wen, Z., Ma, J., Ke, Y., & Qian, Z. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121921 · Cited by 32
Bauckman, K., Matsuda, R., Higgins, C. B., DeBosch, B. J., Wang, C., & Mysorekar, I. U. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00133.2018 · Cited by 31
Wang, J., Dong, A., Liu, G., Anderson, G. J., Hu, Y., Shi, J. Y., Hu, Y., & Nie, G. (2016) · Scientific Reports · doi:10.1038/srep34252 · Cited by 34
[Anemia and inflammatory bowel disease].
de la Morena, F., & Gisbert, J. P. (2008) · PubMed · Cited by 32
Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines
Kanda, J., Uchiyama, T., Tomosugi, N., Higuchi, M., Uchiyama, T., & Kawabata, H. (2009) · International Journal of Hematology · doi:10.1007/s12185-009-0443-x · Cited by 31
Iron Homeostasis and Energy Metabolism in Obesity
Kim, S. L., Shin, S., & Yang, S. J. (2022) · Clinical Nutrition Research · doi:10.7762/cnr.2022.11.4.316 · Cited by 34
Huang, Y., Chuang, J., Yang, Y., Huang, C., Wu, C.-L., & Chen, C. (2009) · Laboratory Investigation · doi:10.1038/labinvest.2009.82 · Cited by 30
TLR4 signaling and the inhibition of liver hepcidin expression by alcohol
Zmijewski, E. M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i34.12161 · Cited by 30
Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2
Wallace, D. F., McDonald, C. J., Ostini, L., & Subramaniam, V. N. (2011) · Blood · doi:10.1182/blood-2010-08-303859 · Cited by 29
Deciphering the role of hepcidin in iron metabolism and anemia management
Kesharwani, P., Dash, D., & Koiri, R. K. (2025) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2025.127591 · Cited by 33
Wang, M., Tang, W., Xin, H., & Zhu, Y. Z. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163289 · Cited by 29
Lainé, F., Laviolle, B., Bardou‐Jacquet, E., Fatih, N., Jézequel, C., Collet, N., Ropert, M., Morçet, J., Hamon, C., Reymann, J., et al. (2017) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12288 · Cited by 29
Korenaga, M., Nishina, S., Korenaga, K., Tomiyama, Y., Yoshioka, N., Hara, Y., Sasaki, Y., Shimonaka, Y., & Hino, K. (2014) · Liver International · doi:10.1111/liv.12675 · Cited by 29
Guan, Y., An, P., Zhang, Z., Zhang, F., Yu, Y., Wu, Q., Shi, Y., Guo, X., Tao, Y., & Wang, F. (2013) · Journal of Nutrition · doi:10.3945/jn.113.174201 · Cited by 29
Sobotta, S., Raue, A., Huang, X., Vanlier, J., Jünger, A., Bohl, S., Albrecht, U., Hahnel, M. J., Wolf, S., Mueller, N. S., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00775 · Cited by 28
“In contrast, the sensitivities of intermediate and late APP genes were similar to that of Socs3—Fgg,Hamp, Il33, Apcs,Hp, andHpxmRNAswere induced from 1 to 10 ng/mL hIL6.”
BackgroundInfluentialThe influence of iron on bone metabolism disorders
Zhang, H., Yang, F., Cao, Z., Xu, Y., & Wang, M. (2023) · Osteoporosis International · doi:10.1007/s00198-023-06937-x · Cited by 28
AMPK Serves as a Therapeutic Target Against Anemia of Inflammation
Wang, M., Xin, H., Tang, W., Li, Y., Zhang, Z., Fan, L., Miao, L., Tan, B., Wang, X., & Zhu, Y. Z. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6846 · Cited by 28
Li, B., Gong, J., Sheng, S., Lu, M., Guo, S., Zhao, X., Zhang, H., Wang, H., Tian, Z., & Tian, Y. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.123 · Cited by 28
Wallace, D. F., & Subramaniam, V. N. (2015) · International Immunology · doi:10.1093/intimm/dxu144 · Cited by 28
the Ochanomizu-Liver Conference Study Group, Ueyama, M., Nakagawa, M., Sakamoto, N., Onozuka, I., Funaoka, Y., Watanabe, T., Nitta, S., Kiyohashi, K., Kitazume, A., et al. (2011) · Antiviral Therapy · doi:10.3851/imp1864 · Cited by 27
Oleanolic acid attenuates liver ischemia reperfusion injury by HO-1/Sesn2 signaling pathway
Hao, B.-B., Pan, X., Fan, Y., Lü, L., Qian, X., Wang, X., Zhang, F., & Rao, J. (2016) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(16)60115-7 · Cited by 27
Xiaoli, A. M., Song, Z., & Yang, F. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009644 · Cited by 28
Foka, P., Dimitriadis, A., Kyratzopoulou, E., Giannimaras, D. A., Sarno, S., Simos, G., Georgopoulou, U., & Mamalaki, A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1621-4 · Cited by 27
Heritage, M. L., Murphy, T. L., Bridle, K. R., Anderson, G. J., Crawford, D. H., & Fletcher, L. M. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00969.x · Cited by 27
Casanovas, G., Banerji, A., D’Alessio, F., Muckenthaler, M. U., & Legewie, S. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003421 · Cited by 26
Serum levels of hepcidin and interleukin 6 in Parkinson’s disease
Kwiatek-Majkusiak, J., Geremek, M., Koziorowski, D., Tomasiuk, R., Szlufik, S., & Friedman, A. (2020) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2020-026 · Cited by 25
Deng, Q., Yang, S., Sun, L., Dong, K., Li, Y., Wu, S., & Huang, R. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1849996 · Cited by 24
GATA-4 transcription factor regulates hepatic hepcidin expression
Island, M., Fatih, N., Leroyer, P., Brissot, P., & Loréal, O. (2011) · Biochemical Journal · doi:10.1042/bj20110225 · Cited by 24
Cyclovirobuxine D pretreatment ameliorates septic heart injury through mitigation of ferroptosis
Wang, J., Guan, P., Chen, Y., Xu, M., Wang, N., & Ji, E. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12106 · Cited by 23
Zuo, E., Lu, Y., Yan, M., Pan, X., & Cheng, X. (2017) · Oncology Letters · doi:10.3892/ol.2017.7574 · Cited by 23
YAMADA, I., Goto, T., Takeuchi, S., Ohshima, S., Yoneyama, K., Shibuya, T., Kataoka, E., Segawa, D., Sato, W., Dohmen, T., et al. (2008) · Cytokine · doi:10.1016/j.cyto.2007.12.003 · Cited by 23
Ishihara, S., Tada, Y., Kawashima, K., Kataoka, M., Sonoyama, H., Yamashita, N., Oka, A., Kusunoki, R., Fukuba, N., Mishima, Y., et al. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.12.010 · Cited by 23
Raha, A. A., Ghaffari, S. D., Henderson, J. W., Chakraborty, S., Allinson, K. S. J., Friedland, R. P., Holland, A. J., Zaman, S. H., Mukaetova-Ladinska, E. B., & Raha‐Chowdhury, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.653591 · Cited by 21
Aladzsity, I., Kovács, M., Semsei, Á. F., Falus, A., Szilágyi, Á., Karádi, I., Varga, G., Füst, G., & Várkonyi, J. (2009) · Leukemia Research · doi:10.1016/j.leukres.2009.03.009 · Cited by 22
Hepcidin in chronic kidney disease anemia
Santos‐Silva, A., Ribeiro, S., Reis, F., & Belo, L. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.012 · Cited by 23
Pathophysiology of Iron Homeostasis during Inflammatory States
Cherayil, B. J. (2015) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2015.07.015 · Cited by 24
Sikorska, K., Romanowski, T., Stalke, P., Iżycka‐Świeszewska, E., & Bielawski, K. P. (2014) · Hepatitis Monthly · doi:10.5812/hepatmon.21184 · Cited by 21
Barney, D. E., Ippolito, J., Berryman, C. E., & Hennigar, S. R. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac129 · Cited by 26
Pathophysiology of perioperative anaemia
Singh, S. P., Gudzenko, V., & Fink, M. P. (2012) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2012.11.002 · Cited by 21
Memoli, B., Salerno, S., Procino, A., Postiglione, L., Morelli, S., Sirico, M. L., Giordano, F., Ricciardone, M., Drioli, E., Andreucci, V. E., et al. (2010) · Clinical Science · doi:10.1042/cs20090634 · Cited by 20
Zhang, F., zhao, P., Qian, Z., & Zhong, M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.649640 · Cited by 19
Recent Developments in Liver Pathology
Yan, B. C., & Hart, J. A. L. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.7.1078 · Cited by 18
Surgical Inflammation Induces Hepcidin Production after Abdominal Surgery
Park, K. H., Sawada, T., Kosuge, T., Kita, J., Shimoda, M., Tomosugi, N., & Kubota, K. (2012) · World Journal of Surgery · doi:10.1007/s00268-012-1473-8 · Cited by 18
Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver
Bloomer, S. A., Kregel, K. C., & Brown, K. E. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2013.07.012 · Cited by 19
Synthetic Porcine Hepcidin Exhibits Different Roles in Escherichia coli and Salmonella Infections
Liu, D., Gan, Z.-S., Wan, M., Xiong, H., Li, Y.-Q., Wang, Y., & Du, H. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02638-16 · Cited by 18
Modifying factors of theHFEhemochromatosis phenotype
Deugnier, Y., & Mosser, J. (2008) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2.4.531 · Cited by 16
Anemia y enfermedad inflamatoria intestinal
de la Morena, F., & Gisbert, J. P. (2008) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082008000500007 · Cited by 17
Przybyszewska, J., Żekanowska, E., Kędziora–Kornatowska, K., Boińska, J., Cichon, R., & Porzych, K. (2013) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.1623 · Cited by 17
Isocitrate treatment of acute anemia of inflammation in a mouse model
Kim, A., Fung, E., Parikh, S. G., Gabayan, V. R., Nemeth, E., & Ganz, T. (2015) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2015.09.007 · Cited by 15
The two facets of gp130 signalling in liver tumorigenesis
Schmidt‐Arras, D., Galun, E., & Rose‐John, S. (2021) · Seminars in Immunopathology · doi:10.1007/s00281-021-00861-0 · Cited by 15
Liu, S., Tsyplenkova, S., Fillebeen, C., & Pantopoulos, K. (2025) · American Journal of Hematology · doi:10.1002/ajh.27710 · Cited by 14
Ganz, T. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-92033-2_3 · Cited by 18
Metadata
- Authors
- Pietrangelo, A., Dierssen, U., Valli, L., Garuti, C., Rump, A., Corradini, E., Ernst, M., Klein, C., & Trautwein, C.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Universitätsklinikum Aachen (DE)
- Ludwig Cancer Research (BE)
- Corresponding author
- Trautwein, Christian
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 132
- Issue
- 1
- Pages
- 294-300
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2046878952
- Cited by
- 315
- References
- 43
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 8 · 2023: 11 · 2022: 9 · 2021: 15 · 2020: 14 · 2019: 13 · 2018: 17 · 2017: 23 · 2016: 18 · 2015: 16 · 2014: 25 · 2013: 25 · 2012: 19
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- hepcidin, STAT3, interleukin-6, gp130, iron homeostasis, hepatocytes, SOCS3, serum amyloid A, RAS/MAPK pathway, liver, hypoferremia, primary hepatocytes
- MeSH terms
- Suppressor of Cytokine Signaling 3 Protein, Animals, Iron, Mice, Mutant Strains, Phosphorylation, RNA, Messenger, Transcription, Genetic, Signal Transduction, Interleukin-6, Hepatocytes, Antimicrobial Cationic Peptides, STAT3 Transcription Factor, Cytokine Receptor gp130, Suppressor of Cytokine Signaling Proteins, Mice, Hepcidins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review