Iodine: It’s Important in Patients That Require Parenteral Nutrition

Zimmermann, Michael B.

doi:10.1053/j.gastro.2009.07.074

Cited by 35Thyroid Disorders and TreatmentsClinical Nutrition and GastroenterologyNutrition and Health Studies

Iodine: It’s Important in Patients That Require Parenteral Nutrition

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Zimmermann, Michael B.·2009·Gastroenterology

DOI 10.1053/j.gastro.2009.07.074

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Abstract

Iodine deficiency has multiple adverse effects on growth and development because of inadequate thyroid hormone production. Four methods are generally recommended for assessment of iodine nutrition: urinary iodine concentration, thyroid size, and blood concentrations of thyroid-stimulating hormone and thyroglobulin. Iodine intakes < or = 1 mg/d are well tolerated by most adults, because the thyroid is able to adjust to a wide range of intakes. A daily dose of 1 microg iodine/kg body weight is recommended for infants and children receiving parenteral nutrition (PN), but this is far below their requirement. Daily iodine requirements in adults receiving enteral nutrition or PN are estimated to be 70-150 microg, but most PN formulations do not contain iodine. Despite this, deficiency is unlikely because absorption from iodine-containing skin disinfectants and other adventitious sources can provide sufficient iodine. However, if chlorhexidine replaces iodine-containing disinfectants for catheter care, iodine deficiency may occur during long-term PN, and periodic testing of thyroid functions may be prudent. Infants may be particularly vulnerable because of their small thyroidal iodine store, but available data do not yet support routine supplementation of preterm infants with iodine. Adults may be less vulnerable because thyroidal iodine stores may be able to support thyroid hormone production for several months. More studies to clarify this issue would be valuable.

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Authors: Zimmermann, M. B.
Affiliations: ETH Zurich (CH)
Corresponding author: Zimmermann, Michael B.
ORCID: Zimmermann, Michael B.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2009-11
Volume: 137
Issue: 5
Pages: S36-S46
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/j.gastro.2009.07.074
OpenAlex: W2094775434
Cited by: 35
References: 90
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 4
FWCI: 1.69
Type: journal article
Language: en
Open access: green
research.wur.nl
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords: iodine deficiency, parenteral nutrition, iodine requirements, thyroid function, urinary iodine, thyroid-stimulating hormone, thyroglobulin, chlorhexidine, catheter care, skin disinfectants, preterm infants, iodine supplementation, enteral nutrition
MeSH terms: Adult, Child, Cognition Disorders, Congenital Hypothyroidism, Deficiency Diseases, Dose-Response Relationship, Drug, Enteral Nutrition, Female, Goiter, Growth Disorders, Humans, Iodine, Parenteral Nutrition, Pregnancy, Pregnancy Complications, Thyroglobulin, Thyroid Gland, Thyroid Hormones, Thyrotropin, Trace Elements, Practice Guidelines as Topic, Perinatal Mortality

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Iodine: It’s Important in Patients That Require Parenteral Nutrition

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