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Cited by 289

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats

Open access
Chambers, Adam P., Jessen, Lene, Ryan, Karen K., Sisley, Stephanie, Wilson–Pérez, Hilary E., Stefater, Margaret A., Gaitonde, Shrawan G., Sorrell, Joyce E., Toure, Mouhamadoul, Berger, Jose, D'Alessio, David A., Woods, Stephen C., Seeley, Randy J., Sandoval, Darleen A.·2011·Gastroenterology
DOI 10.1053/j.gastro.2011.05.050
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Abstract

Background & Aims Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) reduce weight and improve glucose metabolism in obese patients, although it is not clear if metabolic changes are independent of weight loss. We investigated alterations in glucose metabolism in rats following RYGB or VSG. Methods Rats underwent RYGB or VSG and were compared to sham-operated rats that were fed ad lib or pair-fed with animals that received RYGB. Intraperitoneal glucose tolerance and insulin sensitivity tests were performed to assess glycemic function, independent of the incretin response. A hyperinsulinemic euglycemic clamp was used to compare tissue-specific changes in insulin sensitivity following each procedure. A mixed-meal tolerance tests was used to assess the effect of each surgery on post-prandial release of GLP-1(7–36) and glucose tolerance, and were also performed in rats given the GLP-1 receptor antagonist exendin9–39. Results Following RYGB or VSG, glucose tolerance and insulin sensitivity improved, in proportion to weight loss. Hepatic insulin sensitivity was significantly better in rats that received RYGB or VSG, compared with rats fed ad lib or pair-fed, whereas glucose clearance was similar in all groups. During the mixed-meal tolerance test, plasma levels of GLP-1(7–36) and insulin were greatly and comparably increased in rats that received RYGB and VSG, compared with those that were pair-fed or fed ad lib. Administration of a GLP-1 receptor antagonist prevented improvements in glucose and insulin responses after a meal among rats that received RYGB or VSG. Conclusion In obese rats, VSG is as effective as RYGB at increasing secretion of GLP-1 and insulin secretion and at improving hepatic sensitivity to insulin; these effects are independent of weight loss.

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Metadata

Authors
Chambers, A. P., Jessen, L., Ryan, K. K., Sisley, S., Wilson–Pérez, H. E., Stefater, M. A., Gaitonde, S. G., Sorrell, J. E., Toure, M., Berger, J., D'Alessio, D. A., Woods, S. C., Seeley, R. J., & Sandoval, D. A.
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2011-09
Volume
141
Issue
3
Pages
950-958
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2011.05.050
OpenAlex
W2022068139
Cited by
289
References
25
FWCI
26.22
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats. https://app.cochat.ai/papers/10.1053/j.gastro.2011.05.050
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Chambers, A. P., Jessen, L., Ryan, K. K., Sisley, S., Wilson–Pérez, H. E., Stefater, M. A., Gaitonde, S. G., Sorrell, J. E., Toure, M., Berger, J., D'Alessio, D. A., Woods, S. C., Seeley, R. J., & Sandoval, D. A. (2011). Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats. Gastroenterology. https://doi.org/10.1053/j.gastro.2011.05.050

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.