The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
Open accessAbstract
More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“however, may be acquired as later events during systemic treatment for metastatic disease and have been found as subclonal genetic alterations in a subset of CRC patients ([25-27])”
From Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor (2022) · cites this paper as [26]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“First, KRAS mutations are often a founder genetic event involved in the pathogenesis of PDAC and are consistently found in precancerous pancreatic intraepithelial neoplasms”
From Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor (2022) · cites this paper as [26]
Experimental — accuracy not yet measuredIn the citing paper
“KRAS mutations are observed in most low-grade PanINs and IPMNs, suggesting KRAS is the initiating genetic event driving exocrine neoplasia46,47.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Self-citationCirculating mutant DNA to assess tumor dynamics
Diehl, F., Schmidt, K., Choti, M. A., Romans, K. E., Goodman, S. N., Li, M., Thornton, K. A., Agrawal, N., Sokoll, L. J., Szabo, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1789 · Cited by 2,746
Self-citationVincent, A., Herman, J. M., Schulick, R., Hruban, R. H., & Goggins, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62307-0 · Cited by 2,678
Self-citationPreinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471
Self-citationHruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126
Self-citationSenescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909
Progression model for pancreatic cancer.
Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872
Self-citationRecurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786
Self-citationWhen cells get stressed: an integrative view of cellular senescence
Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404
Telomere Shortening Is Nearly Universal in Pancreatic Intraepithelial Neoplasia
van Heek, N. T., Meeker, A. K., Kern, S. E., Yeo, C. J., Lillemoe, K. D., Cameron, J. L., Offerhaus, G. J. A., Hicks, J. L., Wilentz, R. E., Goggins, M. G., et al. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64432-x · Cited by 363
Self-citationLöhr, M., Klöppel, G., Maisonneuve, P., Lowenfels, A. B., & Lüttges, J. (2005) · Neoplasia · doi:10.1593/neo.04445 · Cited by 343
Prasad, N. B., Biankin, A. V., Fukushima, N., Maitra, A., Dhara, S., ELKAHLOUN, A. G., Hruban, R. H., Goggins, M., & Leach, S. D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1413 · Cited by 240
Self-citationIncreased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients
Shi, C., Klein, A. P., Goggins, M., Maitra, A., Canto, M. I., Ali, S. Z., Schulick, R. D., Palmisano, E., & Hruban, R. H. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0004 · Cited by 210
Self-citationWu, A.-L., Kolumam, G., Stawicki, S., Chen, Y., Li, J., Zavala-Solorio, J., Phamluong, K., Feng, B., Li, L., Marsters, S., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002669 · Cited by 184
Vincent, A., Omura, N., Hong, S., Jaffe, A. E., Eshleman, J. R., & Goggins, M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3431 · Cited by 177
Self-citationHigh resolution melting analysis for gene scanning
Erali, M., & Wittwer, C. T. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.013 · Cited by 172
Strobel, O., Rosow, D. E., Rakhlin, E. Y., Lauwers, G. Y., Trainor, A. G., Alsina, J., del Castillo, C. F., Warshaw, A. L., & Thayer, S. P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.12.005 · Cited by 162
Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells
Lee, K. E., & Bar‐Sagi, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.10.020 · Cited by 138
Zou, H., Taylor, W. R., Harrington, J. J., Hussain, F. T. N., Cao, X., Loprinzi, C. L., Levine, T. R., Rex, D. K., Ahnen, D. J., Knigge, K. L., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.023 · Cited by 97
Wan, H., Yuan, W., Ruan, M., Ye, Q., Wang, R., Li, Z., Zhou, G., Yao, Z., & Yang, Y. (2013) · Cited by 1
Flagged first, then by citations
1 of the 22 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Hruban, 2000, Clin Cancer Res, 6, 2969
- Wu, 2011, Sci Transl Med, 3
- Caldwell, 2011, Oncogene
- Wu, 2011, Sci Transl Med, 3
Cited by
Sorted by citations
Ryan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348
Kamisawa, T., Wood, L. D., Itoi, T., & Takaori, K. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00141-0 · Cited by 2,212
Park, W., Chawla, A., & O'Reilly, E. M. (2021) · JAMA · doi:10.1001/jama.2021.13027 · Cited by 2,040
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321
Self-citationKRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
Waters, A. M., & Der, C. J. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031435 · Cited by 875
Metadata
- Authors
- Kanda, M., Matthaei, H., Wu, J., Hong, S., Yu, J., Borges, M., Hruban, R. H., Maitra, A., Kinzler, K., Vogelstein, B., & Goggins, M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Goggins, Michael
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 142
- Issue
- 4
- Pages
- 730-733.e9
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3321090
- OpenAlex
- W2081681778
- Cited by
- 741
- References
- 22
- Citations by year
- 2026: 45 · 2025: 51 · 2024: 47 · 2023: 57 · 2022: 47 · 2021: 76 · 2020: 49 · 2019: 41 · 2018: 61 · 2017: 68 · 2016: 50 · 2015: 44 · 2014: 39 · 2013: 40 · 2012: 25
- FWCI
- 23.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Deutsche Krebshilfe
- Lustgarten Foundation
- National Institutes of Health (CA62924, R01CA120432, P01CA134292, R01CA97075, RC2CA148376)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Keywords
- pancreatic intraepithelial neoplasia, somatic mutations, KRAS, CDKN2A, p16, GNAS, BRAF, pancreatic ductal adenocarcinoma, precancerous lesions, tumor progression, genetic susceptibility
- MeSH terms
- Carcinoma in Situ, Chromogranins, DNA Mutational Analysis, Humans, Mutation, Neoplasm Staging, Pancreatic Neoplasms, Phenotype, Proto-Oncogene Proteins, Baltimore, Proto-Oncogene Proteins p21(ras), ras Proteins, GTP-Binding Protein alpha Subunits, Gs, Cyclin-Dependent Kinase Inhibitor p16, Genetic Predisposition to Disease, Carcinoma, Pancreatic Ductal, Proto-Oncogene Proteins B-raf
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
