Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

Pancreatic Cancer

Spencer, P. M., Cameron, J. L., & Lin, L. (2000) · Cited by 7,202

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969

Circulating mutant DNA to assess tumor dynamics

Diehl, F., Schmidt, K., Choti, M. A., Romans, K. E., Goodman, S. N., Li, M., Thornton, K. A., Agrawal, N., Sokoll, L. J., Szabo, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1789 · Cited by 2,746

Pancreatic cancer

Vincent, A., Herman, J. M., Schulick, R., Hruban, R. H., & Goggins, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62307-0 · Cited by 2,678

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471

Pancreatic Intraepithelial Neoplasia: A New Nomenclature and Classification System for Pancreatic Duct Lesions

Hruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200105000-00003 · Cited by 1,126

Senescence-messaging secretome: SMS-ing cellular stress

Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909

Progression model for pancreatic cancer.

Hruban, R. H., Goggins, M., Parsons, J., & Kern, S. E. (2000) · PubMed · Cited by 872

Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development

Wu, J., Matthaei, H., Maitra, A., Molin, M. D., Wood, L., Eshleman, J., Goggins, M., Canto, M., Schulick, R., Edil, B., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002543 · Cited by 786

When cells get stressed: an integrative view of cellular senescence

Ben-Porath, I., & Weinberg, R. A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420663 · Cited by 404

Pancreatic adenocarcinoma

Ryan, D. P., Hong, T. S., & Bardeesy, N. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404198 · Cited by 2,348

Pancreatic cancer

Kamisawa, T., Wood, L. D., Itoi, T., & Takaori, K. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00141-0 · Cited by 2,212

Pancreatic Cancer

Park, W., Chawla, A., & O'Reilly, E. M. (2021) · JAMA · doi:10.1001/jama.2021.13027 · Cited by 2,040

Pancreatic cancer: Advances and challenges

Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

Waters, A. M., & Der, C. J. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031435 · Cited by 875

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas

Basturk, O., Hong, S.-M., Wood, L. D., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Brosens, L. A. A., Fukushima, N., Goggins, M., Hruban, R. H., et al. (2015) · American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000533 · Cited by 864

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697

KRAS: feeding pancreatic cancer proliferation

Bryant, K. L., Mancias, J. D., Kimmelman, A. C., & Der, C. J. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.004 · Cited by 693

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

Hallin, J., Bowcut, V., Calinisan, A., Briere, D. M., Hargis, L., Engstrom, L. D., Laguer, J., Medwid, J., Vanderpool, D., Lifset, E., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02007-7 · Cited by 553

Genetics and biology of pancreatic ductal adenocarcinoma

Ying, H., Dey, P., Yao, W., Kimmelman, A. C., Draetta, G. F., Maitra, A., & DePinho, R. A. (2016) · Genes & Development · doi:10.1101/gad.275776.115 · Cited by 527

Oncogenic KRAS signalling in pancreatic cancer

EŞER, S., Schnieke, A., Schneider, G., & Saur, D. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.215 · Cited by 528

Pancreatic cancer

Stoop, T. F., Javed, A. A., Oba, A., Koerkamp, B. G., Seufferlein, T. T. W., Wilmink, J. W., & Besselink, M. G. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00261-2 · Cited by 601

Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches

Orth, M., Metzger, P., Gerum, S., Mayerle, J. V., Schneider, G., Belka, C., Schnurr, M., & Lauber, K. (2019) · Radiation Oncology · doi:10.1186/s13014-019-1345-6 · Cited by 523

First-in-Class ERK1/2 Inhibitor Ulixertinib (BVD-523) in Patients with MAPK Mutant Advanced Solid Tumors: Results of a Phase I Dose-Escalation and Expansion Study

Sullivan, R. J., Infante, J. R., Jankú, F., Wong, D. J. L., Sosman, J. A., Keedy, V. L., Patel, M. R., Shapiro, G. I., Mier, J. W., Tolcher, A. W., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1119 · Cited by 446

Pancreatic cancer biology and genetics from an evolutionary perspective

Makohon-Moore, A. P., & Iacobuzio–Donahue, C. A. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.66 · Cited by 436

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Olivares, O., Mayers, J. R., Gouirand, V., Torrence, M. E., Gicquel, T., Borge, L., Lac, S., Roques, J., Lavaut, M.-N., Berthezène, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms16031 · Cited by 413

A model for RAS mutation patterns in cancers: finding the sweet spot

Li, S., Balmain, A., & Counter, C. M. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0076-6 · Cited by 384

Retinoic acid receptors: From molecular mechanisms to cancer therapy

di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

Navas, C., Hernández-Porras, I., Schuhmacher, A. J., Sibilia, M., Guerra, C., & Barbacid, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.001 · Cited by 391

Roles for KRAS in Pancreatic Tumor Development and Progression

di Magliano, M. P., & Logsdon, C. D. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.071 · Cited by 412

Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis

Zhang, Y., Lazarus, J., Steele, N. G., Yan, W., Lee, H.-J., Nwosu, Z. C., Halbrook, C. J., Menjivar, R. E., Kemp, S. B., Sirihorachai, V. R., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0958 · Cited by 385

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data

Connor, A. A., & Gallinger, S. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00418-1 · Cited by 369

MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls

Li, A., Yu, J., Kim, H., Wolfgang, C. L., Canto, M. I., Hruban, R. H., & Goggins, M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3092 · Cited by 295

Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma

Qian, Y., Gong, Y., Fan, Z., Luo, G., Huang, Q., Deng, S., Cheng, H., Jin, K., Ni, Q., Yu, X., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00958-3 · Cited by 312

The Early Detection of Pancreatic Cancer: What Will It Take to Diagnose and Treat Curable Pancreatic Neoplasia?

Lennon, A. M., Wolfgang, C. L., Canto, M. I., Klein, A. P., Herman, J. M., Goggins, M., Fishman, E. K., Kamel, I. R., Weiss, M. J., Diaz, L. A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0734 · Cited by 268

Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance

Zhang, Y., Yan, W., Collins, M. A., Bednar, F., Rakshit, S., Zetter, B. R., Stanger, B. Z., Chung, I., Rhim, A. D., & di Magliano, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1558-t · Cited by 268

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

Poggetto, E. D., Ho, I.-L., Balestrieri, C., Yen, E.-Y., Zhang, S., Citron, F., Shah, R., Corti, D., Diaferia, G. R., Li, C.-Y., et al. (2021) · Science · doi:10.1126/science.abj0486 · Cited by 259

Molecular Pathogenesis of Pancreatic Cancer

Grant, T. J., Hua, K., & Singh, A. (2016) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.09.008 · Cited by 237

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)

Germann, U. A., Furey, B. F., Markland, W., Hoover, R. R., Aronov, A. M., Roix, J. J., Hale, M. R., Boucher, D. M., Sorrell, D. A., Martínez-Botella, G., et al. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0456 · Cited by 240

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

Lee, K. E., Spata, M., Bayne, L. J., Buza, E. L., Durham, A. C., Allman, D., Vonderheide, R. H., & Simon, M. C. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0822 · Cited by 229

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling

Gruber, R., Panayiotou, R., Nye, E. L., Spencer‐Dene, B., Stamp, G., & Behrens, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.006 · Cited by 214

METTL13 methylation of eEF1A increases translational output to promote tumorigenesis

Liu, S., Hausmann, S., Carlson, S. M., Fuentes, M. E., Francis, J., Pillai, R., Lofgren, S. M., Hulea, L., Tandoc, K. V., Lu, J.-W., et al. (2019) · Cell · doi:10.1016/j.cell.2018.11.038 · Cited by 175

The pancreatic cancer genome revisited

Hayashi, A., Hong, J., & Iacobuzio-Donahue, C. A. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00463-z · Cited by 211

CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

Franco, J., Witkiewicz, A. K., & Knudsen, E. S. (2014) · Oncotarget · doi:10.18632/oncotarget.2270 · Cited by 207

Preoperative GNAS and KRAS Testing in the Diagnosis of Pancreatic Mucinous Cysts

Singhi, A. D., Nikiforova, M. N., Fasanella, K. E., McGrath, K. M., Pai, R. K., Ohori, N. P., Bartholow, T. L., Brand, R. E., Chennat, J. S., Lu, X., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0513 · Cited by 207

Organoid models of gastrointestinal cancers in basic and translational research

Lau, H. C.-H., Kranenburg, O., Xiao, H., & Yu, J. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0255-2 · Cited by 205

Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer

Takai, E., Totoki, Y., Nakamura, H. K., Morizane, C., Nara, S., Hama, N., Suzuki, M., Furukawa, E., Kato, M., Hayashi, H., et al. (2015) · Scientific Reports · doi:10.1038/srep18425 · Cited by 196

Pathways of Progression From Intraductal Papillary Mucinous Neoplasm to Pancreatic Ductal Adenocarcinoma Based on Molecular Features

Omori, Y., Ono, Y., Tanino, M. A., Karasaki, H., Yamaguchi, H., Furukawa, T., Enomoto, K., Ueda, J., Sumi, A., Katayama, J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.10.029 · Cited by 189

An iPSC Line from Human Pancreatic Ductal Adenocarcinoma Undergoes Early to Invasive Stages of Pancreatic Cancer Progression

Kim, J., Hoffman, J. P., Alpaugh, R. K., Rhim, A. D., Reichert, M., Stanger, B. Z., Furth, E. E., Sepulveda, A. R., Yuan, C., Won, K., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.036 · Cited by 198

Metastatic pancreatic cancer is dependent on oncogenic Kras in mice

Collins, M. A., Brisset, J.-C., Zhang, Y., Bednar, F., Pierre, J., Heist, K. A., Galbán, C. J., Galbán, S., & di Magliano, M. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049707 · Cited by 178

Evolution and dynamics of pancreatic cancer progression

Yachida, S., & Iacobuzio–Donahue, C. A. (2013) · Oncogene · doi:10.1038/onc.2013.29 · Cited by 185

Mutant TP53 in Duodenal Samples of Pancreatic Juice From Patients With Pancreatic Cancer or High-Grade Dysplasia

Kanda, M., Sadakari, Y., Borges, M., Topazian, M., Farrell, J., Syngal, S., Lee, J., Kamel, I., Lennon, A. M., Knight, S., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.016 · Cited by 181

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

Zeitouni, D., Pylayeva‐Gupta, Y., Der, C. J., & Bryant, K. L. (2016) · Cancers · doi:10.3390/cancers8040045 · Cited by 191

Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts

Kanda, M., Knight, S., Topazian, M. D., Syngal, S., Farrell, J. J., Lee, J. D., Kamel, I. R., Lennon, A. M., Borges, M. W., Young, A., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-302823 · Cited by 170

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms

Yu, J., Sadakari, Y., Shindo, K., Suenaga, M., Brant, A., Almario, J. A. N., Borges, M., Barkley, T., Fesharakizadeh, S., Ford, M., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-311166 · Cited by 164

Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways

Schlitter, A. M., Born, D., Bettstetter, M., Specht, K., Kim‐Fuchs, C., Riener, M., Jeliazkova, P., Sipos, B., Siveke, J. T., Terris, B., et al. (2013) · Modern Pathology · doi:10.1038/modpathol.2013.112 · Cited by 162

Pathology and Molecular Genetics of Pancreatic Neoplasms

Wood, L. D., & Hruban, R. H. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e31827459b6 · Cited by 168

Genetic analyses of isolated high‐grade pancreatic intraepithelial neoplasia (HG‐PanIN) reveal paucity of alterations in TP53 and SMAD4

Hosoda, W., Chianchiano, P. E., Griffin, J. F., Pittman, M. E., Brosens, L. A. A., Noë, M., Yu, J., Shindo, K., Suenaga, M., Rezaee, N., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4884 · Cited by 158

KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis

Wei, D., Wang, L., Yan, Y., Jia, Z., Gagea, M., Li, Z., Zuo, X., Kong, X., Huang, S., & Xie, K. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.02.005 · Cited by 156

High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model

Dawson, D. W., Hertzer, K. M., Moro, A., Donald, G. W., Chang, H.-H., Go, V. L. W., Pandol, S. J., Lugea, A., Gukovskaya, A. S., Li, G., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0065 · Cited by 155

Genetic Basis of Pancreas Cancer Development and Progression: Insights from Whole-Exome and Whole-Genome Sequencing

Iacobuzio–Donahue, C. A., Velculescu, V. E., Wolfgang, C. L., & Hruban, R. H. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0315 · Cited by 155

Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions

Carpenter, E. S., Elhossiny, A. M., Kadiyala, P., Li, J., McGue, J. J., Griffith, B. D., Zhang, Y., Edwards, J., Nelson, S., Lima, F., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0013 · Cited by 157

3D genomic mapping reveals multifocality of human pancreatic precancers

Braxton, A. M., Kiemen, A. L., Grahn, M. P., Forjaz, A., Parksong, J., Babu, J. M., Lai, J., Zheng, L., Niknafs, N., Jiang, L., et al. (2024) · Nature · doi:10.1038/s41586-024-07359-3 · Cited by 165

Perspectives in the treatment of pancreatic adenocarcinoma

Arregui, A. C. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i31.9297 · Cited by 146

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Miyazono, K., Katsuno, Y., Koinuma, D., Ehata, S., & Morikawa, M. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0646-8 · Cited by 145

A Phase II Study of Pelareorep (REOLYSIN®) in Combination with Gemcitabine for Patients with Advanced Pancreatic Adenocarcinoma

Mahalingam, D., Goel, S., Aparo, S., Arora, S. P., Noronha, N., Tran, H., Chakrabarty, R., Selvaggi, G., Gutierrez, A., Coffey, M., et al. (2018) · Cancers · doi:10.3390/cancers10060160 · Cited by 144

Organoid based personalized medicine: from bench to bedside

Li, Y., Tang, P., Cai, S., Peng, J., & Hua, G. (2020) · Cell Regeneration · doi:10.1186/s13619-020-00059-z · Cited by 149

MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice

Collins, M. A., Yan, W., Sebolt–Leopold, J. S., & Pasca di Magliano, M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.052 · Cited by 133

Pancreatic cancer: A comprehensive review and update

Muniraj, T., Jamidar, P. A., & Aslanian, H. R. (2013) · Disease-a-Month · doi:10.1016/j.disamonth.2013.08.001 · Cited by 132

Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression

Ferreira, R. M. M., Sancho, R., Messal, H. A., Nye, E. L., Spencer‐Dene, B., Stone, R. K., Stamp, G., Rosewell, I. R., Quaglia, A., & Behrens, A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.093 · Cited by 130

Precancerous neoplastic cells can move through the pancreatic ductal system

Makohon-Moore, A. P., Matsukuma, K., Zhang, M., Reiter, J. G., Gerold, J. M., Jiao, Y., Sikkema, L., Attiyeh, M. A., Yachida, S., Sandone, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0481-8 · Cited by 120

Early detection of pancreatic cancer using DNA-based molecular approaches

Singhi, A. D., & Wood, L. D. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00470-0 · Cited by 127

Novel Diagnostic and Predictive Biomarkers in Pancreatic Adenocarcinoma

Chang, J. C. S., & Kundranda, M. N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030667 · Cited by 127

ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation

Dumartin, L., Alrawashdeh, W., Trabulo, S. M. D., Radon, T. P., Steiger, K., Feakins, R. M., di Magliano, M. P., Heeschen, C., Esposito, I., Lemoine, N. R., et al. (2016) · Oncogene · doi:10.1038/onc.2016.459 · Cited by 126

KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas

Hsu, M., Sasaki, M., Igarashi, S., Sato, Y., & Nakanuma, Y. (2013) · Cancer · doi:10.1002/cncr.27955 · Cited by 125

Diversity of Precursor Lesions For Pancreatic Cancer: The Genetics and Biology of Intraductal Papillary Mucinous Neoplasm

Patra, K. C., Bardeesy, N. M., & Mizukami, Y. (2017) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2017.3 · Cited by 127

Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells

Pelosi, E., Castelli, G., & Testa, U. (2017) · Biomedicines · doi:10.3390/biomedicines5040065 · Cited by 128

Circulating tumor cells in pancreatic cancer patients: Methods of detection and clinical implications

Tjensvoll, K., Nordgård, O., & Smaaland, R. (2013) · International Journal of Cancer · doi:10.1002/ijc.28134 · Cited by 123

KRAS G12D targeted therapies for pancreatic cancer: Has the fortress been conquered?

Bannoura, S. F., Khan, H. Y., & Azmi, A. S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1013902 · Cited by 122

Inherited pancreatic cancer syndromes

Solomon, S., Das, S., Brand, R., & Whitcomb, D. C. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318278c4a6 · Cited by 120

Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation

Mills, L. D., Zhang, Y., Marler, R. J., Herreros‐Villanueva, M., Zhang, L., Almada, L. L., Couch, F. J., Wetmore, C., di Magliano, M. P., & Fernández-Zapico, M. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438846 · Cited by 120

High-Throughput Microfluidic Labyrinth for the Label-free Isolation of Circulating Tumor Cells

Lin, E., Rivera-Báez, L., Fouladdel, S., Yoon, H. J., Guthrie, S. M., Wieger, J., Deol, Y. S., Keller, E. T., Sahai, V., Simeone, D. M., et al. (2017) · Cell Systems · doi:10.1016/j.cels.2017.08.012 · Cited by 122

Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

Huang, L., Desai, R., Conrad, D. N., Leite, N. C., Akshinthala, D., Lim, C. M., González, R. S., Muthuswamy, L. B., Gartner, Z. J., & Muthuswamy, S. K. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.03.022 · Cited by 119

Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular Questions

Brunner, M., Wu, Z., Krautz, C., Pilarsky, C. P., Grützmann, R., & Weber, G. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184543 · Cited by 121

Kras as a key oncogene and therapeutic target in pancreatic cancer

Collins, M. A., & di Magliano, M. P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00407 · Cited by 114

CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice

Zhang, Y., Yan, W., Mathew, E., Bednar, F., Wan, S., Collins, M. A., Evans, R. A., Welling, T. H., Vonderheide, R. H., & di Magliano, M. P. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0016-t · Cited by 102

Biomarkers for pancreatic cancer: promising new markers and options beyond CA 19-9

Ballehaninna, U. K., & Chamberlain, R. S. (2013) · Tumor Biology · doi:10.1007/s13277-013-1033-3 · Cited by 109

Recent advances in the molecular diagnostics of gastric cancer

Kanda, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i34.9838 · Cited by 109

Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations

Riquelme, E. M., Behrens, C., Lin, H. Y., Simon, G. R., Papadimitrakopoulou, V. A., Izzo, J. G., Moran, C. A., Kalhor, N., Lee, J. J., Minna, J. D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1141 · Cited by 114

Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models

Heinrich, M. A., Mostafa, A. M. R. H., Morton, J. P., Hawinkels, L. J. A. C., & Prakash, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.018 · Cited by 115

State of the art and future directions of pancreatic ductal adenocarcinoma therapy

Neuzillet, C., Tijeras‐Raballand, A., Bourget, P., Cros, J. F., Couvelard, A., Sauvanet, A., Vullierme, M., Tournigand, C., & Hammel, P. R. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.08.006 · Cited by 114

Preclinical models of pancreatic ductal adenocarcinoma

Hwang, C., Boj, S. F., Clevers, H. C., & Tuveson, D. A. (2015) · The Journal of Pathology · doi:10.1002/path.4651 · Cited by 105

Targeting KRAS in pancreatic cancer: new drugs on the horizon

Bannoura, S. F., Uddin, M. H., Nagasaka, M., Fazili, F., Hallak, M. N. A., Philip, P. A., El‐Rayes, B. F., & Azmi, A. S. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09990-2 · Cited by 112

Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα

Yamamoto, K., Tateishi, K., Kudo, Y., Sato, T., Yamamoto, S., Miyabayashi, K., Matsusaka, K., Asaoka, Y., Ijichi, H., Hirata, Y., et al. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu136 · Cited by 104

DeTiN: overcoming tumor-in-normal contamination

Taylor-Weiner, A. N., Stewart, C., Giordano, T. J., Miller, M. L., Rosenberg, M. W., Macbeth, A., Lennon, N. J., Rheinbay, E., Landau, D. A., Wu, C. J., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0036-9 · Cited by 93

Sox9: A Master Regulator of the Pancreatic Program

Seymour, P. A. (2014) · The Review of Diabetic Studies · doi:10.1900/rds.2014.11.51 · Cited by 105

Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment

Polireddy, K., & Chen, Q. (2016) · Journal of Cancer · doi:10.7150/jca.14922 · Cited by 103

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming

Velez-Delgado, A., Donahue, K. L., Brown, K. L., Du, W., Irizarry-Negron, V., Menjivar, R. E., Lasse Opsahl, E. L., Steele, N. G., The, S., Lazarus, J., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.02.016 · Cited by 91

Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine

Conway, J. R. W., Herrmann, D., Evans, T. J., Morton, J. P., & Timpson, P. (2018) · Gut · doi:10.1136/gutjnl-2018-316822 · Cited by 97

Pancreatic cancer: Circulating Tumor Cells and Primary Tumors show Heterogeneous KRAS Mutations

Kulemann, B., Rösch, S., Seifert, S., Timme, S., Bronsert, P., Seifert, G. J., Martini, V., Kuvendjiska, J., Glatz, T., Hussung, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04601-z · Cited by 96

Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed?

Minciacchi, V. R., Zijlstra, A., Rubin, M. A., & Vizio, D. D. (2017) · Prostate Cancer and Prostatic Diseases · doi:10.1038/pcan.2017.7 · Cited by 93

RNA G-Quadruplexes in Kirsten Ras ( KRAS ) Oncogene as Targets for Small Molecules Inhibiting Translation

Miglietta, G., Cogoi, S., Marinello, J., Capranico, G., Tikhomirov, A. S., Shchekotikhin, A. E., & Xodo, L. E. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00622 · Cited by 94

Clinical applications of circulating tumor DNA and circulating tumor cells in pancreatic cancer

Riva, F., Dronov, O. I., Khomenko, D. I., Huguet, F., Louvet, C., Mariani, P., Stern, M., Lantz, O. J., Proudhon, C., Pierga, J., et al. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2016.01.006 · Cited by 97

From somatic mutation to early detection: insights from molecular characterization of pancreatic cancer precursor lesions

Fischer, C. G., & Wood, L. D. (2018) · The Journal of Pathology · doi:10.1002/path.5154 · Cited by 95

Genetics of familial and sporadic pancreatic cancer

Wood, L. D., Yurgelun, M. B., & Goggins, M. G. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.039 · Cited by 91

Novel synthetic curcumin analogues EF31 and UBS109 are potent DNA hypomethylating agents in pancreatic cancer

Nagaraju, G. P., Zhu, S., Wen, J., Farris, A. B., Adsay, V. N., Diaz, R., Snyder, J. P., Shoji, M., & El‐Rayes, B. F. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.002 · Cited by 91

The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia: Autopsy Study Evaluating the Entire Pancreatic Parenchyma

Matsuda, Y., Furukawa, T., Yachida, S., Nishimura, M., Seki, A., Nonaka, K., Aida, J., Takubo, K., Ishiwata, T., Kimura, W., et al. (2017) · Pancreas · doi:10.1097/mpa.0000000000000786 · Cited by 89

HLA ligandome tumor antigen discovery for personalized vaccine approach

Rammensee, H., & Singh‐Jasuja, H. (2013) · Expert Review of Vaccines · doi:10.1586/14760584.2013.836911 · Cited by 92

KRAS promotes tumor metastasis and chemoresistance by repressing RKIP via the MAPK–ERK pathway in pancreatic cancer

Yang, K., Li, Y., Lian, G., Lin, H., Shang, C., Zeng, L., Chen, S., Li, J., Huang, C., Huang, K., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31248 · Cited by 88

ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas

Wang, W., Friedland, S. C., Guo, B., O’Dell, M. R., Alexander, W. B., Whitney‐Miller, C. L., Agostini‐Vulaj, D., Huber, A. R., Myers, J. R., Ashton, J. M., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315541 · Cited by 96

Genetic Alterations Associated With Progression From Pancreatic Intraepithelial Neoplasia to Invasive Pancreatic Tumor

Murphy, S. J., Hart, S. N., Lima, J. F., Kipp, B. R., Klebig, M. L., Winters, J. L., Szabo, C., Zhang, L., Eckloff, B. W., Petersen, G. M., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.049 · Cited by 199

Molecular genetics of pancreatic intraepithelial neoplasia

Feldmann, G., Beaty, R., Hruban, R. H., & Maitra, A. (2007) · Journal of Hepato-Biliary-Pancreatic Surgery · doi:10.1007/s00534-006-1166-5 · Cited by 269

Precursor Lesions of Pancreatic Cancer

Yonezawa, S., Higashi, M., Yamada, N., & Goto, M. (2008) · Gut and Liver · doi:10.5009/gnl.2008.2.3.137 · Cited by 91

KRAS2 Mutations in Human Pancreatic Acinar-Ductal Metaplastic Lesions Are Limited to Those with PanIN: Implications for the Human Pancreatic Cancer Cell of Origin

Shi, C., Hong, S., Lim, P., Kamiyama, H., Khan, M. A., Anders, R. A., Goggins, M., Hruban, R. H., & Eshleman, J. R. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0206 · Cited by 109

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Ma, C., Gocke, C. D., Hruban, R. H., & Belchis, D. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.09.023 · Cited by 19