The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Molecular Diagnosis of Eosinophilic Esophagitis by Gene Expression Profiling
Open accessAbstract
Background & Aims Gene expression profiling provides an opportunity for definitive diagnosis but has not yet been well applied to inflammatory diseases. Herein, we describe an approach for diagnosis of an emerging form of esophagitis, eosinophilic esophagitis (EoE), currently diagnosed by histology and clinical symptoms. Methods We developed an EoE diagnostic panel (EDP), comprising a 96-gene quantitative PCR array and an associated dual-algorithm that uses cluster analysis and dimensionality reduction, using a cohort of randomly selected esophageal biopsy samples from pediatric patients with EoE (n = 15) or without EoE (non-EoE controls, n = 14), subsequently vetted using a separate cohort of 194 pediatric and adult patient samples derived from both fresh or formalin-fixed paraffin embedded (FFPE) tissue: active EoE (n = 91), control (non-EoE and EoE remission, n = 57), histologically ambiguous (n = 34), and reflux (n = 12) samples. Results The EDP identified adult and pediatric patients with EoE with ~96% sensitivity and ~98% specificity, and distinguished patients with EoE in remission from controls, as well as identified patients exposed to swallowed glucorticoids. The EDP could be used with FFPE tissue RNA and distinguished patients with EoE from those with reflux esophagitis, identified by pH-impedance testing. Preliminary evidence showed that the EDP could identify patients likely to have disease relapse following treatment. Conclusions We developed a molecular diagnostic test (referred as the EDP) that identifies patients with esophagitis in a fast, objective, and mechanistic manner, offering an opportunity to improve diagnosis and treatment, and a platform approach for other inflammatory diseases.
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Eosinophilic esophagitis: Updated consensus recommendations for children and adults
Liacouras, C. A., Furuta, G. T., Hirano, I., Atkins, D., Attwood, S. E., Bonis, P. A., Burks, A. W., Chehade, M., Collins, M. H., Dellon, E. S., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.02.040 · Cited by 2,073
Self-citationFuruta, G. T., Liacouras, C. A., Collins, M. H., Gupta, S. K., Justinich, C., Putnam, P. E., Bonis, P., Hassall, E., Straumann, A., & Rothenberg, M. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.017 · Cited by 1,673
Self-citationEotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis
Blanchard, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26679 · Cited by 870
Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis
Gonsalves, N., Policarpio-Nicolas, M., Zhang, Q., Rao, M. S., & Hirano, I. (2006) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2006.04.037 · Cited by 491
Blanchard, C., Mingler, M. K., Vicario, M., Abonia, J. P., Wu, Y. Y., Lu, T. X., Collins, M. H., Putnam, P. E., Wells, S. I., & Rothenberg, M. E. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.10.024 · Cited by 455
Self-citationRemedios, M., Campbell, C., Jones, D. M., & Kerlin, P. (2006) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2005.07.049 · Cited by 373
Blanchard, C., Stucke, E. M., Burwinkel, K., Caldwell, J. M., Collins, M. H., Ahrens, A., Buckmeier, B. K., Jameson, S. C., Greenberg, A., Kaul, A., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903069 · Cited by 295
Self-citationInvolvement of mast cells in eosinophilic esophagitis
Abonia, J. P., Blanchard, C., Butz, B. B., Rainey, H. F., Collins, M. H., Stringer, K., Putnam, P. E., & Rothenberg, M. E. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.04.009 · Cited by 287
Self-citationPeriostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
Blanchard, C., Mingler, M. K., McBride, M., Putnam, P. E., Collins, M. H., Chang, G., Stringer, K., Abonia, J. P., Molkentin, J. D., & Rothenberg, M. E. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.15 · Cited by 280
Self-citationA striking local esophageal cytokine expression profile in eosinophilic esophagitis
Blanchard, C., Stucke, E. M., Rodriguez-Jimenez, B., Burwinkel, K., Collins, M. H., Ahrens, A., Alexander, E. S., Buckmeier Butz, B. K., Jameson, S. C., Kaul, A., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.039 · Cited by 277
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Cited by
Dellon, E. S., Liacouras, C. A., Molina-Infante, J., Furuta, G. T., Spergel, J. M., Zevit, N., Spechler, S. J., Attwood, S. E., Straumann, A., Aceves, S. S., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.009 · Cited by 1,162
Self-citationAlexander, E. S., Martin, L. J., Collins, M. H., Kottyan, L. C., Sucharew, H., He, H., Mukkada, V. A., Succop, P. A., Abonia, J. P., Foote, H., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.07.021 · Cited by 299
Self-citationEpithelial barrier repair and prevention of allergy
Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251
Metadata
- Authors
- Wen, T., Stucke, E. M., Grotjan, T. M., Kemme, K. A., Abonia, J. P., Putnam, P. E., Franciosi, J. P., Garza, J. M., Kaul, A., King, E. C., Collins, M. H., Kushner, J. P., & Rothenberg, M. E.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 145
- Issue
- 6
- Pages
- 1289-1299
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2152560420
- Cited by
- 256
- References
- 17
- FWCI
- 23.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Wen, T., Stucke, E. M., Grotjan, T. M., Kemme, K. A., Abonia, J. P., Putnam, P. E., Franciosi, J. P., Garza, J. M., Kaul, A., King, E. C., Collins, M. H., Kushner, J. P., & Rothenberg, M. E. (2013). Molecular Diagnosis of Eosinophilic Esophagitis by Gene Expression Profiling. Gastroenterology. https://doi.org/10.1053/j.gastro.2013.08.046
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