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Cited by 110Cancer Risks and FactorsHepatocellular Carcinoma Treatment and PrognosisObesity, Physical Activity, Diet

Obesity early in adulthood increases risk but does not affect outcomes of hepatocellular carcinoma

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Hassan, Manal M., Abdel-Wahab, Reham, Kaseb, Ahmed, Shalaby, Ahmed, Phan, Alexandria T., El-Serag, Hashem B., Hawk, Ernest, Morris, Jeff +8 more·2015·Gastroenterology
DOI 10.1053/j.gastro.2015.03.044PMC PMC4778392
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Abstract

Background & aims Despite the significant association between obesity and several cancers, it has been difficult to establish an association between obesity and hepatocellular carcinoma (HCC). Patients with HCC often have ascites, making it a challenge to determine body mass index (BMI) accurately, and many factors contribute to the development of HCC. We performed a case-control study to investigate whether obesity early in adulthood affects risk, age of onset, or outcomes of patients with HCC.Methods We interviewed 622 patients newly diagnosed with HCC from January 2004 through December 2013, along with 660 healthy controls (frequency-matched by age and sex) to determine weights, heights, and body sizes (self-reported) at various ages before HCC development or enrollment as controls. Multivariable logistic and Cox regression analyses were performed to determine the independent effects of early obesity on risk for HCC and patient outcomes, respectively. BMI was calculated, and patients with a BMI of 30 kg/m(2) or greater were considered obese.Results Obesity in early adulthood (age, mid-20s to mid-40s) is a significant risk factor for HCC. The estimated odds ratios were 2.6 (95% confidence interval [CI], 1.4-4.4), 2.3 (95% CI, 1.2-4.4), and 3.6 (95% CI, 1.5-8.9) for the entire population, for men, and for women, respectively. Each unit increase in BMI at early adulthood was associated with a 3.89-month decrease in age at HCC diagnosis (P < .001). Moreover, there was a synergistic interaction between obesity and hepatitis virus infection. However, we found no effect of obesity on the overall survival of patients with HCC.Conclusions Early adulthood obesity is associated with an increased risk of developing HCC at a young age in the absence of major HCC risk factors, with no effect on outcomes of patients with HCC.

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  • Early onset of obesity has a meaningful impact on the development of HCC; in a case-control study of 622 individuals with newly diagnosed HCC and 660 healthy controls, obesity in early adulthood was associated with HCC development.

    “The early onset of obesity has a meaningful impact on the development of HCC, as shown in a case-control study comparing 622 individuals with newly diagnosed HCC and 660 healthy controls, where obesity in early adulthood was associated with HCC development.”

    From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [48]

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  1. [36]Frystyk J Skjaerbaek C Vestbo E Circulating levels of free insulin-like growth factors in obese subjects: the impact of type 2 diabetes Diabetes Metab Res Rev 1999 15 314 322 10585616

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Authors
Hassan, M. M., Abdel-Wahab, R., Kaseb, A., Shalaby, A., Phan, A. T., El-Serag, H. B., Hawk, E., Morris, J., Singh Raghav, K. P., Lee, J.-S., Vauthey, J.-N., Bortus, G., Torres, H. A., Amos, C. I., Wolff, R. A., & Li, D.
Affiliations
  • The University of Texas MD Anderson Cancer Center (US)
  • Houston Methodist (US)
  • Dartmouth College (US)
Corresponding author
Hassan, Manal M.
ORCID
Venue
Gastroenterology
Publisher
Elsevier BV
Published
2015-07
Volume
149
Issue
1
Pages
119-129
ISSN
0016-5085 (ISSN-L)
DOI
10.1053/j.gastro.2015.03.044
PMC
PMC4778392
OpenAlex
W2052145855
Cited by
110
References
66
Citations by year
2026: 4 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 15 · 2019: 7 · 2018: 15 · 2017: 11 · 2016: 11 · 2015: 8
FWCI
6.55
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (CA106458-01, K07CA106458, P30CA023108, P30CA016672)
  • National Institute of Environmental Health Sciences (R03ES11481, R03ES011481)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords
hepatocellular carcinoma, obesity, early adulthood, body mass index, cancer risk, age at diagnosis, hepatitis virus infection, overall survival, sex differences
MeSH terms
Adult, Aged, Aging, Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Male, Middle Aged, Obesity, Risk Factors, Body Mass Index, Case-Control Studies, Age of Onset, Young Adult

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