Gut serotonin is a regulator of obesity and metabolism
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Gut-derived 5-HT can modulate glucose and energy homeostasis and is augmented in patients with type 2 diabetes and the obese.
“Furthermore, gut-derived 5-HT can also modulate glucose and energy homeostasis (68-70), and is augmented in patients with type 2 diabetes (71) and the obese (9).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [70]
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From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works
Self-citationThe diverse metabolic roles of peripheral serotonin
Martin, A. M., Young, R. L., Leong, L., Rogers, G. B., Spencer, N. J., Jessup, C. F., & Keating, D. J. (2017) · Endocrinology · doi:10.1210/en.2016-1839 · Cited by 261 · see citing works
Self-citationAugmented capacity for peripheral serotonin release in human obesity
Young, R. L., Lumsden, A. L., Martin, A. M., Schober, G., Pezos, N., Thazhath, S. S., Isaacs, N. J., Cvijanovic, N., Sun, E. W. L., Wu, T., et al. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0047-8 · Cited by 87 · see citing works
Self-citationThe Regulation of Peripheral Metabolism by Gut-Derived Hormones
Sun, E. W. L., Martin, A. M., Young, R. L., & Keating, D. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00754 · Cited by 71 · see citing works
Self-citationThe nutrient-sensing repertoires of mouse enterochromaffin cells differ between duodenum and colon
Martin, A. M., Lumsden, A. L., Young, R. L., Jessup, C. F., Spencer, N. J., & Keating, D. J. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13046 · Cited by 74 · see citing works
Self-citationGut mechanisms linking intestinal sweet sensing to glycemic control
Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00741 · Cited by 40 · see citing works
Self-citation
- Authors
- Young, R. L., Lumsden, A. L., & Keating, D. J.
- Affiliations
- South Australian Health and Medical Research Institute (AU)
- Flinders University (AU)
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 149
- Issue
- 1
- Pages
- 253-255
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1865421445
- Cited by
- 47
- References
- 0
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 9 · 2021: 2 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 2
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- serotonin, enterochromaffin cells, obesity, brown adipose tissue thermogenesis, tryptophan hydroxylase 1, enteroendocrine cells, metabolic regulation, gut-brain axis, gut microbiota, type 2 diabetes, glucagon-like peptide-1
- MeSH terms
- Animals, Adipose Tissue, Brown, Insulin Resistance, Ion Channels, Obesity, Serotonin, Tryptophan Hydroxylase, Thermogenesis, Mitochondrial Proteins, Non-alcoholic Fatty Liver Disease
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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