The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma
Open accessAbstract
Gastric cancer (GC) is globally the fifth most common cancer and third leading cause of cancer death. A complex disease arising from the interaction of environmental and host-associated factors, key contributors to GC's high mortality include its silent nature, late clinical presentation, and underlying biological and genetic heterogeneity. Achieving a detailed molecular understanding of the various genomic aberrations associated with GC will be critical to improving patient outcomes. The recent years has seen considerable progress in deciphering the genomic landscape of GC, identifying new molecular components such as ARID1A and RHOA, cellular pathways, and tissue populations associated with gastric malignancy and progression. The Cancer Genome Atlas (TCGA) project is a landmark in the molecular characterization of GC. Key challenges for the future will involve the translation of these molecular findings to clinical utility, by enabling novel strategies for early GC detection, and precision therapies for individual GC patients.
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Cites
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Cited by
Ajani, J. A., Lee, J., Sano, T., Janjigian, Y. Y., Fan, D., & Song, S. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.36 · Cited by 594
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ImmunoScore Signature: A Prognostic and Predictive Tool in Gastric Cancer
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Metadata
- Authors
- Tan, P., & Yeoh, K.-G.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 149
- Issue
- 5
- Pages
- 1153-1162.e3
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W1955052620
- Cited by
- 492
- References
- 11
- FWCI
- 25.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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