IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients
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Background: Insulin-like growth factor-1 (IGF-I) signalling is important for cancer initiation and progression. Given the emerging evidence for the role of the stroma in these processes, we aimed to characterize the effects of IGF-I on cancer cells and stromal cells separately. Methods: We used an ex vivo culture model and measured gene expression changes after IGF-I stimulation with cDNA microarrays. In vitro data were correlated with in vivo findings by comparing the results with published expression datasets on human cancer biopsies. Results: Upon stimulation with IGF-I, breast cancer cells and stromal fibroblasts show some common and other distinct response patterns. Among the up-regulated genes in the stromal fibroblasts we observed a significant enrichment in proliferation associated genes. The expression of the IGF-I induced genes was coherent and it provided a basis for the segregation of the patients into two groups. Patients with tumours with highly expressed IGF-I induced genes had a significantly lower survival rate than patients whose tumours showed lower levels of IGF-I induced gene expression (P = 0.029 - Norway/Stanford and P = 7.96e-09 - NKI dataset). Furthermore, based on an IGF-I induced gene expression signature derived from primary lung fibroblasts, a separation of prognostically different lung cancers was possible (P = 0.007 - Bhattacharjee and P = 0.008 - Garber dataset). Conclusion: Expression patterns of genes induced by IGF-I in primary breast and lung fibroblasts accurately predict outcomes in breast and lung cancer patients. Furthermore, these IGF-I induced gene signatures derived from stromal fibroblasts might be promising predictors for the response to IGF-I targeted therapies. See the related commentary by Werner and Bruchim: http://www.biomedcentral.com/1741-7015/8/2
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Brief psychological interventions either using a CBT or ACT approach have demonstrated similar effects of reducing a range of mental health presentations.
“Brief psychological interventions either using a CBT or ACT approach have demonstrated similar effects of reducing a range of mental health presentations.86 87”
From Acceptance and commitment therapy for mild traumatic brain injury (ACTion-mTBI): a quasiexperimental feasibility study (2025) · cites this paper as [86]
The Results section on IGF-I effects and the Discussion address gene expression and cancer outcomes, not psychological interventions. Searches for the quoted claim and for CBT, ACT, and mental-health interventions found no passage comparing their effects. (LLM, conf=0.79)
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- Authors
- Rajski, M., Zanetti-Dällenbach, R., Vogel, B., Herrmann, R., Rochlitz, C., & Buess, M.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Buess, Martin
- Venue
- BMC Medicine
- Published
- 2010-01-05
- Volume
- 8
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC2823652
- OpenAlex
- W2050096609
- Cited by
- 355
- References
- 76
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 17 · 2023: 2 · 2022: 7 · 2021: 43 · 2020: 21 · 2019: 23 · 2018: 32 · 2017: 65 · 2016: 44 · 2015: 18 · 2014: 15 · 2013: 16 · 2012: 18
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (112794, 320000)
- Oncosuisse
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- insulin-like growth factor I, tumor stroma, stromal fibroblasts, breast cancer, lung cancer, prognostic gene signature, patient survival prediction, tumor cell proliferation
- MeSH terms
- Breast Neoplasms, Female, Fibroblasts, Humans, Insulin-Like Growth Factor I, Lung Neoplasms, Prognosis, Stimulation, Chemical, Signal Transduction, Up-Regulation, Gene Expression Regulation, Neoplastic, Cluster Analysis, Stromal Cells, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Databases, Genetic, Cell Line, Tumor, Cell Growth Processes, Kaplan-Meier Estimate
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