The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Rome IV—Functional GI Disorders: Disorders of Gut-Brain Interaction
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The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Postprandial fullness and early satiation (termed early satiety in the ROME criteria) are the cardinal symptoms of postprandial distress syndrome (PDS), a subtype of functional dyspepsia (Drossman et al., 2016).”
From Preliminary data that psychological treatment and baseline anxiety are associated with a decrease in postprandial fullness and early satiation for individuals with bulimia nervosa and related other specified feeding or eating disorder. (2023) · cites this paper as Drossman et al., 2016
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Excessive sympathetic or parasympathetic activity in the ANS can lead to dysregulation within the gut-brain axis contributing to maladaptive gastrointestinal responses and resulting in symptomatic flares (8–12,14).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [10]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“resulting in its re-classification as a disorder of gut-brain interaction, rather than a functional gastrointestinal disorder.”
From British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021) · cites this paper as [32]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“IBS is a disorder of altered bidirectional communication between the gut and brain (via the gut-brain axis), and has a biopsychosocial aetiology.32”
From British Society of Gastroenterology guidelines on the management of irritable bowel syndrome (2021) · cites this paper as [32]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Such monitoring might be achieved through a set of noninvasive electrocardiography parameters, collectively referred to as heart rate variability (HRV), that provides an indirect measure of the autonomic nervous system (ANS) (8–14).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [10]
Experimental — accuracy not yet measured
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“PDS and EDs have similar clinical presentations, including a higher prevalence in cisgender females compared to cisgender males (American Psychiatric Association, 2013;Drossman et al., 2016), postprandial nausea (Drossman et al., 2016;Heruc et al., 2019;Keel et al., 2018;Koch et al., 1998), and elevated anxiety (Aro et al., 2009;Swinbourne & Touyz, 2007).”
From Preliminary data that psychological treatment and baseline anxiety are associated with a decrease in postprandial fullness and early satiation for individuals with bulimia nervosa and related other specified feeding or eating disorder. (2023) · cites this paper as Drossman et al., 2016
Experimental — accuracy not yet measuredIn the citing paper
“In order to assess the effect of severe vomiting on the homeostasis of each patient, biochemical tests addressed to dyselectrolytemia, acid‐base balance, should be performed [ 250 ].”
From European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025) · cites this paper as [250]
In the citing paper
“In difficult cases, other rare conditions should be explored [ 250 ].”
From European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025) · cites this paper as [250]
In the citing paper
“CNVS adheres to a biopsychosocial model in the field of neurogastroenterology, resulting from complex and reciprocal interactions between biological, psychological, and social factors, rather than from linear monocausal etiopathogenic processes [ 224 , 250 , 314 , 379 ].”
From European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025) · cites this paper as [250]
In the citing paper
“Histamine H1 antagonists (e.g., meclizine, promethazine) are effective for the treatment of chronic nausea and vomiting.”
From European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025) · cites this paper as [250]
In the citing paper
“Muscarinic M1 antagonists (e.g., scopolamine) are effective for the treatment of chronic nausea and vomiting.”
From European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025) · cites this paper as [250]
In the citing paper
“5‐HT3 antagonists are effective for the treatment of chronic nausea and vomiting.”
From European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025) · cites this paper as [250]
In the citing paper
“Dopamine‐2 antagonists are effective for the treatment of chronic nausea and vomiting.”
From European Guideline on Chronic Nausea and Vomiting—A UEG and ESNM Consensus for Clinical Management (2025) · cites this paper as [250]
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Citations
Cites
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Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV
Drossman, D. A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.032 · Cited by 2,444
Self-citationThe functional gastrointestinal disorders and the Rome III process
Drossman, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.008 · Cited by 2,416
Self-citationStanghellini, V., Chan, F. K. L., Hasler, W. L., Malagelada, J. R., Suzuki, H., Tack, J., & Talley, N. J. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.011 · Cited by 1,572
Self-citationChildhood Functional Gastrointestinal Disorders: Child/Adolescent
Hyams, J. S., Lorenzo, C. D., Saps, M., Shulman, R. J., Staiano, A., & van Tilburg, M. A. L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.015 · Cited by 1,426
Childhood Functional Gastrointestinal Disorders: Neonate/Toddler
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Development and Validation of the Rome IV Diagnostic Questionnaire for Adults
Palsson, O. S., Whitehead, W. E., van Tilburg, M. A. L., Chang, L., Chey, W., Crowell, M. D., Keefer, L., Lembo, A. J., Parkman, H. P., Rao, S. S. C., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.014 · Cited by 719
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Metadata
- Authors
- Drossman, D. A., & Hasler, W. L.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 150
- Issue
- 6
- Pages
- 1257-1261
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2342528407
- Cited by
- 1,928
- References
- 37
- Citations by year
- 2026: 291 · 2025: 271 · 2024: 235 · 2023: 222 · 2022: 200 · 2021: 214 · 2020: 201 · 2019: 127 · 2018: 102 · 2017: 50 · 2016: 10
- FWCI
- 90.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- Rome IV criteria, functional gastrointestinal disorders, gut-brain axis, Rome criteria, functional bowel disorders, Rome III
- MeSH terms
- Gastrointestinal Microbiome, Brain, Gastrointestinal Diseases, Humans, Immunity, Mucosal, Gastrointestinal Tract, Dysbiosis
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