Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer
Weiler, Sofia M.E., Pinna, Federico, Wolf, Thomas, Lutz, Teresa, Geldiyev, Aman, Sticht, Carsten, Knaub, Maria, Thomann, Stefan, Bissinger, Michaela, Wan, Shan, Rössler, Stephanie, Becker, Diana, Gretz, Norbert, Lang, Hauke, Bergmann, Frank, Ustiyan, Vladimir, Kalin, Tatiana V., Singer, Stephan, Lee, Ju-Seog, Marquardt, Jens U., Schirmacher, Peter, Kalinichenko, Vladimir V., Breuhahn, Kai·2017·Gastroenterology
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- Hypermethylation and low expression of FOXM1 predisposes women to unexplained recurrent miscarriage by impairing trophoblast stem cell proliferationYouqing Jiang, Huimin Zhu, Tingting Wang, Tong Hai, Jinkai Liu, Yi Yang, Xiaobo Zhou, Xiru Liu · 2024 · Cellular Signalling
- TPX2 overexpression promotes sensitivity to dasatinib in breast cancer by activating YAP transcriptional signalingCarlos Marugán, Natalia Sanz‐Gómez, Beatriz Ortigosa, Ana Monfort‐Vengut, Cristina Bertinetti, Ana Teijo, Marta González, Alicia Alonso de la Vega, Marı́a José Lallena, Gema Moreno‐Bueno et al. · 2024 · Molecular Oncology
- FOXM1 / DEPDC1 feedback loop promotes hepatocarcinogenesis and represents promising targets for cancer therapyTeng Wei, Chenquan Zeng, Qineng Li, Zhiyuan Xiao, Leisheng Zhang, Qiangnu Zhang, Lili Ren · 2024 · Cancer Science
- Sepsis induces the cardiomyocyte apoptosis and cardiac dysfunction through activation of YAP1/Serpine1/caspase-3 pathwayXueyuan Long, Yanpeng Yang, Ke Zhou · 2024 · Open Medicine
- Network analyses elucidate the role of SMYD3 in esophageal squamous cell carcinomaXinning Liu, Zhoude Zheng, Chuhong Chen, Simin Guo, Zhennan Liao, Yue Li, Ying Zhu, Haiying Zou, Jian‐Yi Wu, Wenming Xie et al. · 2017 · FEBS Open Bio
- Transcription factor Sp1 regulates mitotic chromosome assembly and segregationSamuel P. Flashner, Michelle L. Swift, Aislinn Sowash, Alexander N. Fahmy, Jane Azizkhan‐Clifford · 2022 · Chromosoma
- Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsHuiyan Luo, Jixin Chen, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Xiongwen Wang · 2023 · Clinical Epigenetics
- Multi-omics after O-GlcNAc alteration identified cellular processes promoting aneuploidy after loss of O-GlcNAc transferaseSamuel S. Boyd, Dakota R. Robarts, Khue Nguyen, Maite T. Villar, Ibtihal M. Alghusen, Manasi Kotulkar, Aspin R. Denson, Halyna Fedosyuk, Stephen A. Whelan, Norman C.Y. Lee et al. · 2024 · Molecular Metabolism
- Identification of Key Biomarkers and Pathways in Small‐Cell Lung Cancer Using Biological AnalysisHuanqing Liu, Tingting Li, Xunda Ye, Jun Lyu · 2021 · BioMed Research International
- Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type IaMartijn G. S. Rutten, Lei Yu, Joanne A. Hoogerland, Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore Alagere Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel Thomas et al. · 2023 · Cancer & Metabolism
- The Cell Polarity Protein MPP5/PALS1 Controls the Subcellular Localization of the Oncogenes YAP and TAZ in Liver CancerMarcell Tóth, Shan Wan, Jennifer Schmitt, Patrizia Birner, Teng Wei, Fabian von Bubnoff, Carolina De La Torre, Stefan Thomann, Federico Pinna, Peter Schirmacher et al. · 2025 · International Journal of Molecular Sciences
- YAP induziert chromosomale Instabilität in LeberkrebspatientenS Weiler · 2018 · Der Pathologe
- Identification of POLQ as a chromosomal instability-associated biomarker for hepatocellular carcinomaYing Cai, Na Wang, Qiang Liu, Yidi Wang, Dina Liu, Jing Liu, Hengyu Zhou · 2025 · Genes & Diseases
- Emerging Roles for Transcription Factors During MitosisSamuel P. Flashner, Jane Azizkhan‐Clifford · 2025 · Cells
- Discovery and characterization of sulfonamide derivatives as transcriptional enhanced associate domain (TEAD) inhibitors: a novel approach for targeting hepatocellular carcinomaYang Lu, Jian Gao, Jun Mo, Qiuqiu Shi, Yu Guo, Haifeng Chen, Linjie Li, Jingyi Zhao, Jinxin Che, Jiankang Zhang et al. · 2025 · Bioorganic Chemistry
- Nichtautonome Effekte des Onkogens YAP in der HepatokarzinogeneseSimone Marquard, Stefan Thomann, S Weiler, Carsten Sticht, N. Gretz, Peter Schirmacher, Kai Breuhahn · 2017 · Der Pathologe
- Bioinformatics analysis of different candidate genes involved in hepatocellular carcinoma induced by HepG2 cells or tumor cells of patientsXiang Zhang, Songna Yin, Ke Ma · 2020 · Journal of International Medical Research
- Role of Hippo signaling pathway in occurrence, development, and treatment of primary hepatocellular carcinomaHui-Xian Tang, Fu-Zhen Yi, Zan-Song Huang, Gui-Liu Huang · 2022 · World Chinese Journal of Digestology
- Modulatory act of diverse transcriptional factors in liver carcinomaRashmi Nagesh, Rajeshwari H. Patil, M. Naveen Kumar, K. M. Kiran Kumar, Shivaleela Biradar, Babu R. Lamani · 2022 · Elsevier eBooks
- Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type IaMartijn G. S. Rutten, Lei Yu, Joanne A. Hoogerland, Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore Alagere Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel Thomas et al. · 2023 · Research Square
- The chromosomal instability 25 gene signature is identified in clear cell renal cell carcinoma and serves as a predictor for survival and Sunitinib responseChang Wang, Xin Qin, Wei Guo, Jing Wang, Li Liu, Zhiqing Fang, Huiyang Yuan, Yidong Fan, Dawei Xu · 2023 · Frontiers in Oncology
- YAP promotes chromosomal instability by transcriptionally activating AJUBA through its super enhancer in breast cancerQingwen Huang, Rui Zhang, Weijian Meng, Hongliang Dong, Zhihong Qi, Zhuo Chen, Liang Liu, Jie Shen, Daxing Xie · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- The prognostic significance of FoxM1 and its immune regulatory function in Liver Hepatocellular CarcinomaChangyou Li, Qi Yao, Cunhai Chen, Xiaocui Bu, Xuezhen Ma, Peng Zhao · 2024 · Research Square
- Multi-Omics after O-GlcNAc Alteration Identifies Cellular Processes Working Synergistically to Promote AneuploidySamuel S. Boyd, Dakota R. Robarts, Khue P. Nguyen, Maite T. Villar, Ibtihal M. Alghusen, Manasi Kotulkar, Aspin R. Denson, Halyna Fedosyuk, Stephen A. Whelan, Norman C.Y. Lee et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote cancer immune evasionToshinori Ando, Kento Okamoto, Kuniaki Sato, Yusuke Goto, Hiroki Izumi, Nanako Kataoka, Yume Ueda, Ramiro Iglesias‐Bartolomé, Tetsuya Yoshimoto, Tomoaki Shintani et al. · 2024 · Research Square
- Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast CancerRui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie · 2025 · Advanced Science
- Additional file 1 of Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinomaMarcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M.E. Weiler, Carsten Sticht, De La Torre, Carolina, Melina Rausch, Thomas Albrecht et al. · 2021 · Figshare
- Additional file 3 of YAP1 is essential for malignant mesothelioma tumor maintenanceLoreley Calvet, Odette Dos-Santos, Emmanuel Spanakis, Véronique Jean‐Baptiste, Jean-Christophe Le Bail, Armelle Buzy, Pascal Paul, Henry, Christophe, Sandrine Valence, Colette Dib et al. · 2022 · Figshare
- Additional file 1 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 3 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 10 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 3 of Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinomaMarcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M.E. Weiler, Carsten Sticht, De La Torre, Carolina, Melina Rausch, Thomas Albrecht et al. · 2021 · Figshare
- Additional file 2 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 8 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 2 of Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinomaMarcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M.E. Weiler, Carsten Sticht, De La Torre, Carolina, Melina Rausch, Thomas Albrecht et al. · 2021 · Figshare
- Additional file 1 of Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type IaMartijn G. S. Rutten, Lei, Yu, Hoogerland, Joanne H., Vincent W. Bloks, Hong Yang, Trijnie Bos, Kishore Alagere Krishnamurthy, Aycha Bleeker, Mirjam H. Koster, Rachel Thomas et al. · 2024 · Figshare
- Additional file 7 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 4 of Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinomaMarcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M.E. Weiler, Carsten Sticht, De La Torre, Carolina, Melina Rausch, Thomas Albrecht et al. · 2021 · Figshare
- Additional file 4 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 11 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 9 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 6 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 5 of Comprehensive DNA methylation profiling of COVID-19 and hepatocellular carcinoma to identify common pathogenesis and potential therapeutic targetsLuo, Huiyan, Chen, Jixin, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Wang, Xiongwen · 2023 · Figshare
- Additional file 5 of Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinomaMarcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M.E. Weiler, Carsten Sticht, De La Torre, Carolina, Melina Rausch, Thomas Albrecht et al. · 2021 · Figshare
- YAP1 Dysfunction Promotes Molecular Properties Linked to Breast Cancer SusceptibilityTara Fresques, Jennifer C. Lopez, Deborah Hussey, Masaru Miyano, James C. Garbe, Stefan Hinz, Rosalyn W. Sayaman, Aimin Li, Daniel B. Schmolze, Serenity Van Bedford et al. · 2025 · Cancer Prevention Research
- The vitamin K oxidoreductase VKORC1L1 prevents oxidative stress in hepatocytes and protects from MASLD and hepatocellular carcinomaShayesteh Kiani, Julie Lacombe, B. Ashok Reddy, Émilie Gobeil, René P. Michel, Benoît J. Arsenault, Mathieu Ferron · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Structural basis for the FOXM1 DNA binding domain to specific dsDNA substrateMingxuan Sun, Lei Wang, Jing Cui, Liang Zhang, Yunyu Shi, Chao Xu, Wanwan Zhou, Mengqi Lv · 2026 · Acta Biochimica et Biophysica Sinica
- The chromosomal instability associated gene C2orf76 exerts dual roles in colorectal cancer through pyroptosis and chemotherapy responseLi Zhang, Zhu Song, Pinjie Zhang, Yuyu Jiang, Yan Xiang, Zeting Wang, Yingying Ding, Bing Rui, Yangyang Zhou, Junfeng Jiang et al. · 2026 · Frontiers in Oncology
- Kaiso Is a Novel TAZ-Interaction Partner That Promotes Hepatic Stellate Cell Activation and Regulates the Downstream lncRNA HIF1A-AS3Amira Khaled Abdelhamid, Fabiola Pedrini, Jennifer Schmitt, Ibrahim Hassan Fayed, Aya Osama, Hannah Hisham Rashwan, Diana M. F. Hanna, Esther T. Menze, Sameh Magdeldin, Marcin Luzarowski et al. · 2026 · International Journal of Molecular Sciences
- Dysregulation of the Hippo pathway enhances PD-L2 transcription to promote immune evasion in head and neck squamous cell carcinomaToshinori Ando, Kento Okamoto, Kuniaki Sato, Yusuke Goto, Hiroki Izumi, Nanako Kataoka, Yume Ueda, Yukina Kobayashi, Kai OMACHI, 前田 優雅 et al. · 2026 · Communications Biology