Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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TEAD mediates YAP-dependent gene induction and growth control

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Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP

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A mechanism linking extra centrosomes to chromosomal instability

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YAP1 increases organ size and expands undifferentiated progenitor cells

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Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

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A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early-Stage Hepatocellular Carcinoma Patients

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Hippo Pathway Activity Influences Liver Cell Fate

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FoxM1 is required for execution of the mitotic programme and chromosome stability

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The Hippo signaling pathway in stem cell biology and cancer

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Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

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Restriction of intestinal stem cell expansion and the regenerative response by YAP

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Examining the link between chromosomal instability and aneuploidy in human cells

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Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

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Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival

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Centrosome amplification and the development of cancer

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YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes

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Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liverPreprint

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Chromosomal instability and cancer: a complex relationship with therapeutic potential

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Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression

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AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma

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The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

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Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

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Mad2 Is a Critical Mediator of the Chromosome Instability Observed upon Rb and p53 Pathway Inhibition

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The Transcription Factor FOXM1 (Forkhead box M1)

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Emerging evidence on the role of the Hippo/YAP pathway in liver physiology and cancer

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A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

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Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis†

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Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma

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CDK1 Phosphorylation of YAP Promotes Mitotic Defects and Cell Motility and Is Essential for Neoplastic Transformation

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Polyploidization of liver cells

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Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis

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Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma

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KIF20A mRNA and Its Product MKlp2 Are Increased During Hepatocyte Proliferation and Hepatocarcinogenesis

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LinkCluE: AMATLABPackage for Link-Based Cluster Ensembles

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Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways

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Expression and Function Analysis of Mitotic Checkpoint Genes Identifies TTK as a Potential Therapeutic Target for Human Hepatocellular Carcinoma

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FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer

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N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability

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Single-Cell Analysis of Ploidy and Centrosomes Underscores the Peculiarity of Normal Hepatocytes

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Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma

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The CIN4 Chromosomal Instability qPCR Classifier Defines Tumor Aneuploidy and Stratifies Outcome in Grade 2 Breast Cancer

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Association of MAD2 Expression with Mitotic Checkpoint Competence in Hepatoma Cells

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circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma

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FOXM1 and Cancer: Faulty Cellular Signaling Derails Homeostasis

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Signaling pathways in hepatocellular carcinoma

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The Hippo pathway in normal development and cancer

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FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression

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Hepatocyte Stress Increases Expression of Yes‐Associated Protein and Transcriptional Coactivator With PDZ‐Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis

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Role of the transcriptional coactivators YAP/TAZ in liver cancer

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Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival

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Resolvin D1 prevents epithelial-mesenchymal transition and reduces the stemness features of hepatocellular carcinoma by inhibiting paracrine of cancer-associated fibroblast-derived COMP

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ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression

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Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis

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FOXM1 promotes proliferation in human hepatocellular carcinoma cells by transcriptional activation of CCNB1

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The Dominant Role of Forkhead Box Proteins in Cancer

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The Role of Photoactivated and Non-Photoactivated Verteporfin on Tumor

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p53 shades of Hippo

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Hypoxia‐driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial–mesenchymal transition and cancer stem cell‐like properties by modulating forkhead box protein M1

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The Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective

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Liver Inflammation and Hepatobiliary Cancers.

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Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

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Hippo Signaling in the Liver – A Long and Ever-Expanding Story

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YAP-dependent induction of UHMK1 supports nuclear enrichment of the oncogene MYBL2 and proliferation in liver cancer cells

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Alternative Splicing in Hepatocellular Carcinoma

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Signaling pathways in liver cancer: pathogenesis and targeted therapy

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YAP-associated chromosomal instability and cholangiocarcinoma in mice

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Depletion of TRRAP Induces p53‐Independent Senescence in Liver Cancer by Down‐Regulating Mitotic Genes

Kwan, S., Sheel, A., Song, C., Zhang, X., Jiang, T., Dang, H. T., Cao, Y., Özata, D. M., Mou, H., Yin, H., et al. (2019) · Hepatology · doi:10.1002/hep.30807 · Cited by 70 · see citing works

Hepatic Hippo signaling inhibits development of hepatocellular carcinoma

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Aurora kinase A stabilizes FOXM1 to enhance paclitaxel resistance in triple‐negative breast cancer

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Single-keratinocyte transcriptomic analyses identify different clonal types and proliferative potential mediated by FOXM1 in human epidermal stem cells

Enzo, E., Secone Seconetti, A., Forcato, M., Tenedini, E., Polito, M. P., Sala, I., Carulli, S., Contin, R., Peano, C., Tagliafico, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22779-9 · Cited by 66 · see citing works

FOXF1 transcription factor promotes lung morphogenesis by inducing cellular proliferation in fetal lung mesenchyme

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Aberrantly high activation of a FoxM1–STMN1 axis contributes to progression and tumorigenesis in FoxM1-driven cancers

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Prioritizing Popular Proteins in Liver Cancer: Remodelling One-Carbon Metabolism

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TAZ target gene ITGAV regulates invasion and feeds back positively on YAP and TAZ in liver cancer cells

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Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma

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TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy

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Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis

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FOXM1-Mediated LINC-ROR Regulates the Proliferation and Sensitivity to Sorafenib in Hepatocellular Carcinoma

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TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis

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AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis

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Helicobacter pylori‐induced YAP1 nuclear translocation promotes gastric carcinogenesis by enhancing IL‐1β expression

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Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation

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YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver Tumorigenesis

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Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis

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Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer

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YAP promotes sorafenib resistance in hepatocellular carcinoma by upregulating survivin

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Role Of YAP Signaling in Regulation of Programmed Cell Death and Drug Resistance in Cancer

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The emerging roles of m6A modification in liver carcinogenesis

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Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

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SK-Hep1: not hepatocellular carcinoma cells but a cell model for liver sinusoidal endothelial cells.

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FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation

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TEAD4 as an Oncogene and a Mitochondrial Modulator

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Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade

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Alterations of the nuclear transport system in hepatocellular carcinoma – New basis for therapeutic strategies

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Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development

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Identification of biomarkers for Barcelona Clinic Liver Cancer staging and overall survival of patients with hepatocellular carcinoma

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Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway

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ETV4 potentiates nuclear YAP retention and activities to enhance the progression of hepatocellular carcinoma

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Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2‐Dependent Mitotic Cell Death

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YAP‐induced Ccl2 expression is associated with a switch in hepatic macrophage identity and vascular remodelling in liver cancer

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USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1.

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Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes‐Associated Protein 1 Activation and Transient Expansion of Stem‐Like Cancer Cells

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A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma

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Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice

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Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review)

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YAP1 induces hyperglycemic stress-mediated cardiac hypertrophy and fibrosis in an AKT-FOXM1 dependent signaling pathway

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FoxM1 Induces CCl2 Secretion From Hepatocytes Triggering Hepatic Inflammation, Injury, Fibrosis, and Liver Cancer

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Chromosome 8p engineering reveals increased metastatic potential targetable by patient-specific synthetic lethality in liver cancer

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Overexpression of FoxM1 predicts poor prognosis of intrahepatic cholangiocarcinoma

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Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression

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Proteinase-activated receptor 2 promotes tumor cell proliferation and metastasis by inducing epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma

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The transcription factor FoxM1 activates Nurr1 to promote intestinal regeneration after ischemia/reperfusion injury

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Ku70 Binding to YAP Alters PARP1 Ubiquitination to Regulate Genome Stability and Tumorigenesis

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c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression

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A20/TNFAIP3 Discriminates Tumor Necrosis Factor (TNF)-Induced NF-κB from JNK Pathway Activation in Hepatocytes

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Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo‐Independent Regulation of Heat Shock Protein 70 Family Members

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YAP1 is essential for malignant mesothelioma tumor maintenance

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Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer

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Discovering master regulators in hepatocellular carcinoma: one novel MR, SEC14L2 inhibits cancer cells

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Advances in prognostic and therapeutic targets for hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The hippo signaling pathway

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CD168+ macrophages promote hepatocellular carcinoma tumor stemness and progression through TOP2A/β-catenin/YAP1 axis

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From imaging to clinical outcome: dual-region CT radiomics predicting FOXM1 expression and prognosis in hepatocellular carcinoma

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N-Myristoylation by NMT1 Is POTEE-Dependent to Stimulate Liver Tumorigenesis via Differentially Regulating Ubiquitination of Targets

Zhu, G., Wang, F., Li, H., Zhang, X., Wu, Q., Liu, Y., Qian, M., Guo, S., Yang, Y., Xue, X., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.681366 · Cited by 16 · see citing works

SEPTIN10-mediated crosstalk between cytoskeletal networks controls mechanotransduction and oncogenic YAP/TAZ signaling

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Research progress on the role of cholesterol in hepatocellular carcinoma

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FOXM1 is critical for the fitness recovery of chromosomally unstable cells

Pan, F., Chocarro, S., Ramos, M. J., Chen, Y., de la Vega, A. A., Somogyi, K., & Sotillo, R. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05946-2 · Cited by 15 · see citing works

PLCε knockdown prevents serine/glycine metabolism and proliferation of prostate cancer by suppressing YAP.

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Spatial modeling reveals nuclear phosphorylation and subcellular shuttling of YAP upon drug-induced liver injury

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Stress-triggered YAP1/SOX2 activation transcriptionally reprograms head and neck squamous cell carcinoma for the acquisition of stemness

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HELLS Is Negatively Regulated by Wild-Type P53 in Liver Cancer by a Mechanism Involving P21 and FOXM1

Schuller, S., Sieker, J., Riemenschneider, P., Köhler, B., Drucker, E., Weiler, S. M. E., Dauch, D., Sticht, C., Goeppert, B. F., Roessler, S. K., et al. (2022) · Cancers · doi:10.3390/cancers14020459 · Cited by 13 · see citing works

FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve Sheath Tumor Therapy

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Cellular Origin of Hepatocellular Carcinoma

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Nuclear translocation of YAP drives BMI ‐associated hepatocarcinogenesis in hepatitis B virus infection

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CRKL Enhances YAP Signaling through Binding and JNK/JUN Pathway Activation in Liver Cancer

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ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma

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Dynamic YAP expression in the non-parenchymal liver cell compartment controls heterologous cell communication

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The Role of Yes‐Associated Protein in Inflammatory Diseases and Cancer

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Epithelial cell transforming 2 is regulated by Yes-associated protein 1 and mediates pancreatic cancer progression and metastasis

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Etiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC

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α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration

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SNX9 Inhibits Cell Proliferation and Cyst Development in Autosomal Dominant Polycystic Kidney Disease via Activation of the Hippo-YAP Signaling Pathway

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YAP induziert chromosomale Instabilität in Leberkrebspatienten

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Deregulation of the Hippo/YAP pathway drives chromosomal instability (CIN) in hepatocellular carcinoma by regulating the transcription factor FoxM1

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Dysregulation of Hippo/Yap signaling induces chromosome instability in intrahepatic cholangiocarcinoma

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The yes-associated protein target gene U2AF homology motif kinase 1 facilitates tumor initiation and progression in liver cancer

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YAP-associated chromosomal instability and cholangiocarcinoma in mice

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