Association between proton pump inhibitor use and cognitive function in women
Open accessAbstract
Background & aims Studies have reported associations between proton pump inhibitor (PPI) use and dementia. However, data are lacking on long-term PPI use and cognitive function. We therefore examined associations between PPI use and performance in tests of cognitive function. Because of shared clinical indications, we examined associations for H2 receptor antagonists (H2RAs) as a secondary aim.Methods We used prospectively collected data on medication use and other potential risk factors from 13,864 participants in the Nurses' Health Study II who had completed a self-administered computerized neuropsychological test battery. Multivariable linear regression models were used to examine associations between medication use and composite scores of psychomotor speed and attention, learning and working memory, and overall cognition.Results We observed a modest association between duration of PPI use and scores for psychomotor speed and attention (mean score difference for PPI use of 9-14 years vs never users, -0.06; 95% confidence interval, -0.11 to 0.00; P trend = .03). After controlling for H2RA use, the magnitude of this score difference was attenuated. Among individuals who did not use PPIs regularly, duration of H2RA use was associated with poorer cognitive scores, with the strongest association apparent for learning and working memory (mean score difference for H2RA users of 9-14 years vs never users, -0.20; 95% confidence interval, -0.32 to -0.08; P trend < .001).Conclusions In an analysis of data from the Nurses' Health Study II, we did not observe a convincing association between PPI use and cognitive function. Our data do not support the suggestion that PPI use increases dementia risk. Because our primary hypothesis related to PPI use, our findings for H2RAs should be interpreted with caution.
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Outcomes for proton pump inhibitors vary, with some studies showing no association.
“Outcomes vary, with some studies showing no association.”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [447]
Proton pump inhibitors have been shown to cause dysbiosis and are associated with cognitive decline.
“Another group of drugs that has been shown to cause dysbiosis and is associated with cognitive decline is the proton pump inhibitors (PPI) (446, 447).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [447]
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Ulcus-ventriculi- und Ulcus-duodeni-Krankheit
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Ulcus-ventriculi- und Ulcus-duodeni-Krankheit
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- Authors
- Lochhead, P., Hagan, K., Joshi, A. D., Khalili, H., Nguyen, L. H., Grodstein, F., & Chan, A. T.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Chan, Andrew T.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 153
- Issue
- 4
- Pages
- 971-979.e4
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC5623145
- OpenAlex
- W2606356262
- Cited by
- 83
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 11 · 2022: 14 · 2021: 15 · 2020: 12 · 2019: 7 · 2018: 12 · 2017: 4
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- proton pump inhibitors, H2 receptor antagonists, cognitive function, dementia risk, psychomotor speed, attention, chronic drug administration, women, Nurses' Health Study II
- MeSH terms
- Adult, Aged, Attention, Cognition, Cognition Disorders, Drug Administration Schedule, Female, Histamine H2 Antagonists, Humans, Memory, Middle Aged, Neuropsychological Tests, Nurses, Prognosis, Prospective Studies, Psychomotor Performance, Risk Factors, Sex Factors, Time Factors, United States, Multivariate Analysis, Linear Models, Risk Assessment, Proton Pump Inhibitors
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