The DOI matches its Crossref record; 141 of the 142 references it cites were found in a registry or an index.
Behavioral and Diet Therapies in Integrated Care for Patients With Irritable Bowel Syndrome
Abstract
Irritable bowel syndrome (IBS) is a common, symptom-based condition that has negative effects on quality of life and costs health care systems billions of dollars each year. Until recently, management of IBS has focused on over-the-counter and prescription medications that reduce symptoms in fewer than one-half of patients. Patients have increasingly sought natural solutions for their IBS symptoms. However, behavioral techniques and dietary modifications can be effective in treatment of IBS. Behavioral interventions include gastrointestinal-focused cognitive behavioral therapy and gut-directed hypnotherapy to modify interactions between the gut and the brain. In this pathway, benign sensations from the gut induce maladaptive cognitive or affective processes that amplify symptom perception. Symptoms occur in response to cognitive and affective factors that trigger fear of symptoms or lack of acceptance of disease, or from stressors in the external environment. Among the many dietary interventions used to treat patients with IBS, a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols is the most commonly recommended by health care providers and has the most evidence for efficacy. Patient with IBS who choose to follow a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols should be aware of its 3 phases: restriction, reintroduction, and personalization. Management of IBS should include an integrated care model in which behavioral interventions, dietary modification, and medications are considered as equal partners. This approach offers the greatest likelihood for success in management of patients with IBS.
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“While evidence for timely, collaborative care is limited in the HSD/hEDS population, integrated care of patients with irritable bowel syndrome and other DGBI have been shown to improve health‐related quality of life, patient psychological wellbeing and other outcomes. 84 , 85”
From Hypermobile Ehlers–Danlos syndrome and disorders of the gastrointestinal tract: What the gastroenterologist needs to know (2022) · cites this paper as [85]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.031 · Cited by 2,866
Self-citationCollaborative Management of Chronic Illness
Von Korff, M., Gruman, J., Schaefer, J., Curry, S. J., & Wagner, E. H. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-12-199712150-00008 · Cited by 1,269
Wenzlaff, R. M., & Wegner, D. M. (2000) · Annual Review of Psychology · doi:10.1146/annurev.psych.51.1.59 · Cited by 1,063
Irritable bowel syndrome: a clinical review.
Chey, W., Kurlander, J. E., & Eswaran, S. (2015) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2015.0954 · Cited by 748
Self-citationDiets that differ in their FODMAP content alter the colonic luminal microenvironment
Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2015) · Gut · doi:10.1136/gutjnl-2014-307264 · Cited by 681
Self-citationBöhn, L., Störsrud, S., Liljebo, T. M., Collin, L., Lindfors, P., Törnblom, H., & Simrén, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.054 · Cited by 628
Staudacher, H. M., Lomer, M. C. E., Anderson, J. L., Barrett, J. S., Muir, J. G., Irving, P. M., & Whelan, K. (2012) · The Journal of Nutrition · doi:10.3945/jn.112.159285 · Cited by 590
Self-citationOng, D. K., Mitchell, S. B., Barrett, J. S., Shepherd, S. J., Irving, P. M., Biesiekierski, J. R., Smith, S., Gibson, P. R., & Muir, J. G. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06370.x · Cited by 583
Self-citationShepherd, S. J., Parker, F. C., Muir, J. G., & Gibson, P. R. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.02.058 · Cited by 549
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Research works printed but not linked: 2
- McNamara, 2019, A nursing and allied health-led functional gastrointestinal disorders clinic is well received by patients, highly efficient, cost-effective, and reduces the need for medical intervention, J Gastroenterol Hepatol, 34, 169
- Scarlata, 2020, From a dietitian’s perspective, diets for IBS are not one size fits all, Clin Gastroenterol Hepatol, 18543
Cited by
Sorted by citations
Items 101–154 of 154
Galea, H., Caruana, M., & Jones, P. F. (2025) · Open Health · doi:10.1515/ohe-2025-0072 · Cited by 2
Topan, R., Pandya, S., Chance, P., Zárate-López, N., Aziz, Q., Bassett, P., Kyle, J., Whelan, K., & Fikree, A. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.11.022 · Cited by 1
Self-citationFikree, A., Zárate-López, N., Brugaletta, C., McEvedy, C., Hamilton, Z., & Martin, L. D. (2026) · Frontline Gastroenterology · doi:10.1136/flgastro-2025-103174 · Cited by 1
“This model enables the dietitian to work in a genuinely integrated manner within the MDT. 45 In joint consultations with the gastroenterologist, the dietitian helps to reframe patients’ perceived ‘food reactions’ within the context of visceral hypersensitivity rather than simple food intolerance,…”
InfluentialIzquierdo-Veraza, D., Waseem, M. R., Venezia, J., Montero, A. M., Jones, S., Kadariya, J., Gupta, A., Xu, H., & Shin, A. (2026) · Neurogastroenterology & Motility · doi:10.1111/nmo.70283 · Cited by 1
“Developing individualized treatment plans that target modifiable aspects of the disease experience, including cognitive and emotional factors through multi-faceted approaches, could enhance responses to treat-ment and improve patient outcomes [8].”
Advances in the mechanism of low FODMAP diet in the treatment of irritable bowel syndrome: a review
Chen, B., Zhang, Y., Du, L., Jin, J., & Dai, N. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1719048 · Cited by 1
“Among the available options, the low FODMAP diet has become the most evidence-supported dietary intervention strategy for treating IBS (9).”
Chen, L. J., Burr, R. L., Cain, K. C., Kamp, K., & Heitkemper, M. M. (2023) · Biological Research For Nursing · doi:10.1177/10998004231186188 · Cited by 2
“…may be important when considering treatment options such as HRV biofeedback, self-management cognitive behavioral therapy, exercise, acupuncture, and hypnosis for patients with IBS and concurrent upper GI symptoms (Caillet et al., 2022; Chen et al., 2022; Chey et al., 2021; Jarrett et al., 2016).”
BackgroundAlsolami, A. A. (2023) · International Journal Of Pharmaceutical Research And Allied Sciences · doi:10.51847/19xy8dgjwy · Cited by 1
Low FODMAP (fermentable oligo-, di-, monosaccharides, and polyol) diet goes global
Quigley, E. M. M. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab084 · Cited by 1
Katzenstein, C., & Keefer, L. (2024) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.18372 · Cited by 1
“We appreciate the complex undertaking of evaluating psychological factors as part of dietary intervention, in pursuit of the growing need for personalised, integrated care for IBS [2].”
Self-citationLow-FODMAP-Diät – Lösung aller Probleme?
Heinrich, H. S. (2021) · Schweizer Gastroenterologie · doi:10.1007/s43472-021-00035-1
Dolor abdominal funcional en adultos y niños, intestino permeable e hipnoterapia
Schmulson, M. J., & Saps, M. (2021) · NeuroGastroLATAM Reviews · doi:10.24875/ngl.m21000020
Psychological and Nutritional Factors in Pelvic Floor Disorders
Quinton, S., & Doerfler, B. (2022) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.10.009
Ochoa, K. J. C., Samant, S., Liu, A., Duysburgh, C., Marzorati, M., Singh, P., Hachuel, D., Chey, W. D., & Wallach, T. E. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.16.492152
Self-citationRej, A., Sanders, D. S., & Aziz, I. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.06.024
Dietary Concerns and Patient-Focused Care in Irritable Bowel Syndrome.
Chang, L. (2022) · PubMed Central
Lactose Intolerance and Osteoporosis Development in Irritable Bowel Syndrome Patients
Aycan, M., & Açıkgöz, A. (2022) · Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi · doi:10.46413/boneyusbad.1184664
Hotfiel, K., Rist, M., & Raithel, M. (2023) · Die Gastroenterologie · doi:10.1007/s11377-023-00703-5
“Wenngleich die Evidenzen hierzu niedrig sind, sollte bezüglich der Diät bei den beiden pathophysiologischen Szenarien unterschieden werden, denn die unter 1.) aufgeführte Konstellation erfordern oft eine Karenz gegenüber pollenkreuzreaktiven Lebensmitteln (Nüsse, Kern- und Steinobst, Gewürze, pflanzliche Allergene) au…”
BackgroundInfluentialWas ist gesichert bei Reizdarmsyndrom und Nahrungsmittelunverträglichkeiten?
Raithel, M., Hotfiel, A.-K., Rist, M., & Konturek, P. C. (2023) · Gastro-News · doi:10.1007/s15036-023-3331-y
Dietary Interventions and Brain–Gut Disorders
Quigley, E. M. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00013-8
Alonso, M., Malagelada, C., & Serra, J. (2024) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2024.10368/2024
Kososki, E., Soares, C. M., Dutra, Z. C., & de Freitas, M. E. S. (2024) · Journal Archives of Health · doi:10.46919/archv5n3espec-270
Taking your mind off breathlessness
Calverley, P. M. A. (2024) · European Respiratory Journal · doi:10.1183/13993003.01141-2024
28/w mit chronischen Bauchschmerzen und Verstopfung
Jasper, D. (2025) · Die Gastroenterologie · doi:10.1007/s11377-025-00857-4
Gomez-Escudero, O., Remes-Troche, J. M., Coss-Adame, E., García‐Zermeño, K. R., Aquino-Matus, J. E., Pavón, J. J., Valdovinos-García, L. R., Vargas-Martínez, M. A., Amieva‐Balmori, M., Arenas-Martinez, J. S., et al. (2025) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2024.12.001
Integrating brain–gut behaviour therapies in clinical practice: leveraging the resources you have
Kinsinger, S. W., Ballou, S., & Keefer, L. (2025) · Frontline Gastroenterology · doi:10.1136/flgastro-2024-103012
Self-citationLinking Gut Microbiota and Irritable Bowel Syndrome (Ibs): A Review
Karasek, M., Szyszko, M., Polański, K., Andrzejczuk, S., Kasela, M., & Kosikowska, U. (2025) · Postępy Mikrobiologii - Advancements of Microbiology · doi:10.2478/am-2025-0012 · Cited by 1
Welcher Patient mit Magen-Darm-Beschwerden braucht psychosomatischen Support?
Keip, B., & Dejaco, C. (2025) · Journal für Gastroenterologische und Hepatologische Erkrankungen · doi:10.1007/s41971-025-00243-5
Gereizter Darm durch Nahrungsmittelunverträglichkeit?
Hotfiel, K., Sarsour, A., & Raithel, M. (2025) · Gastro-News · doi:10.1007/s15036-025-3951-5
“Unter den Ernährungsfaktoren hat sie eine mit am besten gesicherte Evidenz [1, 36, 37, 38].”
Jacobs, J. P., Lagishetty, V., Hauer, M. C., Labus, J. S., Dong, T. S., Toma, R., Vuyisich, M., Naliboff, B. D., Lackner, J. M., Gupta, A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22602221
Madjirebaye, P., Penga, Z., Mueeda, A., Huang, T., Peng, F., Xiao, M., Liua, Z., Béchir, M., Allasra, Y., Xu, Y., et al. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10911-w · Cited by 1
“It produces acute mucosal hydration changes and secondary disturbances in gut microbiota [5, 18].”
Badwei, N., Abdelsalam, A., Wassif, G. O., & EL-Din, H. E. S. (2026) · Infection · doi:10.1007/s15010-026-02724-y
Badwei, N., Abdelsalam, A., Wassif, G. O., & EL-Din, H. E. S. (2026) · Tropical Medicine & International Health · doi:10.1111/tmi.70079
Gorczyca, K., Sapeda, N., Lusarczyk, W., Truszyńska-Zawisza, A., Młocek, A., Romanowska, Z., & Białas, A. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.4(48).2025.4134
Kaye, A. J., Meyers, S. R., Hachuel, D., Wells, J., Wallach, T. E., & Thor, S. (2026) · Gastro Hep Advances · doi:10.1016/j.gastha.2026.100898
Gut Health Restoration and Microbiome Repopulation in Individuals With Irritable Bowel Syndrome
Valk, R., & Valk, M. (2026) · Nutrition Today · doi:10.1097/nt.0000000000000798
Berry, S. K., Varma, S., Basnayake, C., Ahn, J. C., Berinstein, J. A., Cook, D. J., Chan, W. W., Allen, J. I., & Chey, W. (2026) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000004002
Self-citationVeldman, F., Sweerts, K. W. E., Leue, C., Brouns, J., Mulkens, S., Brabant, B. B., Beckers, R. C. J., Conchillo, J. M., & Keszthelyi, D. (2026) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s581482
Behavioral Interventions for Health Behaviors in Primary Care
Jackson, K., Montgomery, M., Daniel, R. M., Botello, R., Mixco, G., Mosley, T., Porter, D., Sekula, M. K. K., Swanson, J., Roberman, S., et al. (2026) · Springer eBooks · doi:10.1007/978-3-032-09558-9_9 · Cited by 1
A Primer for Discussing Complementary and Integrative Medicine in Gastroenterology Settings
Thakur, E. R., Craven, M. R. A., Keefer, L., & Hass, D. J. (2026) · Neurogastroenterology & Motility · doi:10.1111/nmo.70313
Self-citationLow-FODMAP diet in the management of irritable bowel syndrome
Kaymak, M. Ş., & Ekici, E. M. (2026) · Nutrition & Food Science · doi:10.1108/nfs-12-2025-0440
Thuen, C., Kenter, R. M. F., Aßmus, J., Steinsvik, E. K., Vikøren, L. A. S., Lied, G. A., & Berentsen, B. (2026) · Internet Interventions · doi:10.1016/j.invent.2026.100949 · Cited by 1
“Combined with limited patient access to integrated care, these challenges highlight the need for more accessible and scalable low-threshold interventions (Chey et al., 2021).”
Irritable bowel syndrome and its impact on utilization and outcomes in elective thoracolumbar fusion
Izima, C., Khan, F. A., Ayloo, B., Fuller, J. S., Shlobin, N. A., Lee, I. S., Chou, D., & Chan, A. K.-H. (2026) · Brain and Spine · doi:10.1016/j.bas.2026.106087
“Importantly, recent reviews by Chey et al. (2021) and Warner et al. (2025) highlight how integrated care for patients with IBS, including gastroenterology management, low-FODMAP therapy, and behavioral interventions, can significantly reduce symptom burden and healthcare utilization while improving…”
Anderson, J. L., Ljótsson, B., Yao, C. K., Murray, H. B., & Biesiekierski, J. R. (2026) · Proceedings of The Nutrition Society · doi:10.1017/s002966512610305x
Afshari, S. A., Nobakht, M., bakhti, S. J., aghaei, E. H., Sheikhi, M., & Afshari, S. A. (2026) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/22840265261428162
Chakraborty, S. (2026) · Lifestyle Medicine · doi:10.1002/lim2.70069
“Integrated care models that combine dietary, behavioral, and pharmacologic strategies are now advocated to address the multifaceted nature of IBS and optimize long-term outcomes [ 1, 4, 5 ].”
InfluentialThe Road from Rome V to the Pediatric Clinic: New Perspectives in 2026
Rosen, R., Benninga, M. A., Lorenzo, C. D., Saps, M., & Nurko, S. (2026) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000004181
Manning, L. P., Tuck, C. J., Biesiekierski, J. R., & Willcox, J. C. (2026) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2026.156437
Altuwayjiri, R., Martin, L. D., Zárate-López, N., Vari, C., Topan, R., Aziz, Q., & Fikree, A. (2026) · Neurogastroenterology & Motility · doi:10.1111/nmo.70417
“Given such prevalence and the routine use of dietary modification to manage DGBI symptoms [72, 73], clinical guidelines [10] and authors [11, 13] have recommended using SCOFF as a screening tool before initiating DGBI treatment.”
Ergün, U., & Tan, T. B. (2026) · Comprehensive physiology · doi:10.1002/cph4.70249
“Rather than acting independently, these mechanisms interact dynamically to establish a chronic state of low-grade inflammation and neuroimmune dysregulation that perpetuates gastrointestinal symptoms and psychological distress (Chey et al. 2021; Staudacher et al. 2023).”
Tian, L., Bai, Y., Wang, S., Wang, C., Gao, J., Zhou, J., & Xiang, W. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1715972
“Thus, treating IBS-D necessitates an individualized approach that combines medication, dietary adjustments, and lifestyle changes (Lembo et al., 2022; Shah et al., 2022; Chey et al., 2021; Wechsler and Shah, 2021; Wang et al., 2023; Camilleri and Boeckxstaens, 2017; Mozaffari et al., 2024).”
Swain, A., Malinao, J. A., Soutter, V., & Loblay, R. H. (2026) · Nutrients · doi:10.3390/nu18193220
“Low-excitotoxin (low-glutamate) diet Fibromyalgia [145–149] Low-FODMAP diet Irritable bowel syndrome (IBS) [150–155] Low-gluten/wheat diet Non-celiac gluten/wheat intolerance [87–90 ,”
Chang, L., Corsetti, M., Chey, W. D., Ford, A. C., Schmulson, M. J., Shin, A., Barbara, G., Ballou, S., Mayer, E. A., Siah, K. T. H., et al. (2026) · Nature Reviews Disease Primers · doi:10.1038/s41572-026-00741-7
“An integrated multidisciplinary approach addressing both gastrointestinal and psychological symptoms is therefore preferred 159 .”
Self-citationBorghini, R., Trecca, A., Bella, A., Spagnuolo, A., Borghini, F., & Borghini, G. (2026) · Gastroenterology Insights · doi:10.3390/gastroent17040061
Metadata
- Authors
- Chey, W. D., Keefer, L., Whelan, K., & Gibson, P. R.
- Affiliations
- University of Michigan (US)
- King's College London (GB)
- Monash University (AU)
- Corresponding author
- Chey, William D.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 160
- Issue
- 1
- Pages
- 47-62
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W3093338182
- Cited by
- 154
- References
- 142
- Citations by year
- 2026: 29 · 2025: 21 · 2024: 22 · 2023: 20 · 2022: 35 · 2021: 25
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Almond Board of California
- Meso Scale Diagnostics
- International Nut and Dried Fruit Council
- Takeda Pharmaceuticals U.S.A.
- Pfizer
- Allergan
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, behavior therapy, dietary therapy, gut-directed hypnotherapy, cognitive behavioral therapy, FODMAP diet, integrated care, symptom perception, stress, personalized nutrition
- MeSH terms
- Behavior Therapy, Humans, Delivery of Health Care, Integrated, Irritable Bowel Syndrome
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