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Cited by 549Gastrointestinal motility and disordersGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Dietary Triggers of Abdominal Symptoms in Patients With Irritable Bowel Syndrome: Randomized Placebo-Controlled Evidence

Shepherd, Susan J., Parker, Francis C., Muir, Jane G., Gibson, Peter R.·2008·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2008.02.058
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Abstract

Background & aims Observational studies suggest dietary fructose restriction might lead to sustained symptomatic response in patients with irritable bowel syndrome (IBS) and fructose malabsorption. The aims of this study were first to determine whether the efficacy of this dietary change is due to dietary fructose restriction and second to define whether symptom relief was specific to free fructose or to poorly absorbed short-chain carbohydrates in general. Methods The double-blinded, randomized, quadruple arm, placebo-controlled rechallenge trial took place in the general community. The 25 patients who had responded to dietary change were provided all food, low in free fructose and fructans, for the duration of the study. Patients were randomly challenged by graded dose introduction of fructose, fructans, alone or in combination, or glucose taken as drinks with meals for maximum test period of 2 weeks, with at least 10-day washout period between. For the main outcome measures, symptoms were monitored by daily diary entries and responses to a global symptom question. Results Seventy percent of patients receiving fructose, 77% receiving fructans, and 79% receiving a mixture reported symptoms were not adequately controlled, compared with 14% receiving glucose (P Conclusions In patients with IBS and fructose malabsorption, dietary restriction of fructose and/or fructans is likely to be responsible for symptomatic improvement, suggesting efficacy is due to restriction of poorly a…

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  • Genome-wide association studies have provided associations with variants on chromosome 9 (9q31.2 locus) that are linked to the functions of diverse ion channels and autonomic dysfunction, and mutations in the sucrase-isomaltase gene.

    “genome-wide association studies have provided associations with variants on chromosome 9 (9q31.2 locus) that are linked to the functions of diverse ion channels and autonomic dysfunction, 56 and mutations in the sucrase-isomaltase gene, 38,39 as previously discussed.”

    From Irritable bowel syndrome (2020) · cites this paper as [39]

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Authors
Shepherd, S. J., Parker, F. C., Muir, J. G., & Gibson, P. R.
Affiliations
Box Hill Hospital (AU)
Corresponding author
Shepherd, Susan J.
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2008-07
Volume
6
Issue
7
Pages
765-771
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2008.02.058
OpenAlex
W2155620449
Cited by
549
References
5
Citations by year
2026: 8 · 2025: 19 · 2024: 13 · 2023: 23 · 2022: 27 · 2021: 32 · 2020: 27 · 2019: 34 · 2018: 35 · 2017: 56 · 2016: 53 · 2015: 33 · 2014: 40 · 2013: 42 · 2012: 31
FWCI
24.30
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
irritable bowel syndrome, fructose malabsorption, fructose restriction, fructans, short-chain carbohydrates, abdominal symptoms, fructose intolerance
MeSH terms
Adult, Diarrhea, Diet, Female, Fructans, Fructose, Glucose, Humans, Male, Middle Aged, Placebos, Abdominal Pain, Irritable Bowel Syndrome

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