Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review
Open accessAbstract
BACKGROUND & AIMS: The incidence of inflammatory bowel disease (IBD) is increasing internationally, particularly in nations with historically low rates. Previous reports of the epidemiology of pediatric-onset IBD identified a paucity of data. We systematically reviewed the global trends in incidence and prevalence of IBD diagnosed in individuals <21 years old over the first 2 decades of the 21st century. METHODS: We systematically reviewed studies indexed in MEDLINE, EMBASE, Airiti Library, and SciELO from January 2010 to February 2020 to identify population-based studies reporting the incidence and/or prevalence of IBD, Crohn's disease, ulcerative colitis, and/or IBD-unclassified. Data from studies published before 2000 were derived from a previously published systematic review. We described the geographic distribution and trends in children of all ages and limiting to very early onset (VEO) IBD. RESULTS: A total of 131 studies from 48 countries were included. The incidence and prevalence of pediatric-onset IBD is highest in Northern Europe and North America and lowest in Southern Europe, Asia, and the Middle East. Among studies evaluating trends over time, most (31 of 37, 84%) studies reported significant increases in incidence and all (7 of 7) reported significant increases in prevalence. Data on the incidence and prevalence of VEO-IBD are limited to countries with historically high rates of IBD. Time trends in the incidence of VEO-IBD were visually heterogeneous. CONCLUSIONS: Rates of pediatric-onset IBD continue to rise around the world and data are emerging from regions where it was not previously reported; however, there remains a paucity of data on VEO-IBD and on pediatric IBD from developing and recently developed countries.
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Childhood-onset inflammatory bowel disease tends to have a more severe evolutive course than IBD diagnosed in adulthood.
“Childhood-onset inflammatory bowel disease tends to have a more severe evolutive course than IBD diagnosed in adulthood”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [31]
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- Authors
- Kuenzig, M. E., Fung, S. G., Marderfeld, L., Mak, J. W. Y., Kaplan, G. G., Ng, S. C., Wilson, D. C., Cameron, F., Henderson, P., Kotze, P. G., Bhatti, J., Fang, V., Gerber, S., Guay, E., Kotteduwa Jayawarden, S., Kadota, L., Maldonado D., F., Osei, J. A., Sandarage, R., Stanton, A., Wan, M., Bhatti, J., Gerber, S., Guay, E., Jayawarden, S. K., Kadota, L., Maldonado, F., Maltus, E., Bhattacharya, S., Osei, J., Sandarage, R., Stanton, A., Wan, M., & Benchimol, E. I.
- Affiliations
- Children's Hospital of Eastern Ontario (CA)
- Chinese University of Hong Kong (HK)
- University of Calgary (CA)
- Royal Hospital for Sick Children (GB)
- Alder Hey Children's NHS Foundation Trust (GB)
- Pontifícia Universidade Católica do Paraná (BR)
- Hospital for Sick Children (CA)
- Saskatchewan Health Authority (CA)
- University of Toronto (CA)
- Corresponding author
- Benchimol, Eric I.
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 162
- Issue
- 4
- Pages
- 1147-1159.e4
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W4206405543
- Cited by
- 608
- References
- 46
- Citations by year
- 2026: 118 · 2025: 165 · 2024: 147 · 2023: 136 · 2022: 42
- FWCI
- 19.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gastroenterology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, cc-by)
- Funders
- Gilead Sciences
- Crohn's and Colitis Canada
- AbbVie
- Planning and Budgeting Committee of the Council for Higher Education of Israel
- Takeda Pharmaceutical Company
- Janssen Pharmaceuticals
- Shire
- Mitacs
- Novartis
- Ferring Pharmaceuticals
- Canadian Institutes of Health Research
- Canadian Child Health Clinician Scientist Program
- National Rosacea Society
- Canadian Association of Gastroenterology
- Pfizer
- Merck
- Children's Hospital of Eastern Ontario Research Institute
- AbbVie Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- pediatric inflammatory bowel disease, Crohn's disease, ulcerative colitis, IBD-unclassified, incidence trends, prevalence trends, developing countries
- MeSH terms
- Adult, Child, Chronic Disease, Colitis, Ulcerative, Crohn Disease, Humans, Inflammatory Bowel Diseases, Incidence, Prevalence, Young Adult
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