Emerging trends of inflammatory bowel disease in South Korea: A nationwide population‐based study
Abstract
Background and Aim: Little is known regarding the exact burden of inflammatory bowel disease (IBD) in Asian countries because previous epidemiologic studies were hospital based. We aimed to develop and validate an operational definition of IBD cases from health insurance claims data and to examine the epidemiological features of IBD in Korea. Methods: We analyzed stratified sample data from the Korean Health Insurance Review and Assessment (2010–2016) database using 12 different definitions and applied the best definition to the entire (2007–2016) dataset. Results: The definition that combined the International Classification of Disease 10th revision code with IBD‐specific medications had the best performance characteristics among the 12 tested definitions. During the 8‐year study period, IBD prevalence increased from 25 345 in 2009 to 47 444 in 2016. Over that period, the prevalence of Crohn's disease increased 1.9‐fold (from 16.0/100 000 in 2009 to 29.6/100 000 in 2016) and that of ulcerative colitis increased 1.6‐fold (from 41.4/100 000 in 2009 to 66.0/100 000 in 2016). Similarly, the estimated incidence of Crohn's disease also increased 1.2‐fold (from 2.4 to 2.9 per 100 000) and that of ulcerative colitis rose 1.3‐fold (from 4.0 to 5.3 per 100 000). During the study period, the predominant increase in IBD incidence was among younger individuals, especially those aged < 30 years. Conclusion: Patients with IBD can be accurately identified using Korean insurance claims data by combining information regarding the International Classification of Disease 10th revision codes and the IBD medications used. The prevalence of IBD continues to increase, with an apparent shift toward younger (< 30 years) age groups.
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In South Korea, IBD prevalence was 57.37 per 100,000 in 2009 and had not quite doubled to 95.59 per 100,000 in 2016, suggesting a Prevalence Doubling Period near 10 years.
“By contrast, in South Korea, which began westernizing earlier, the prevalence of IBD was 57.37 per 100,000 in 2009, but had not quite doubled to 95.59 per 100,000 in 2016, suggesting a Prevalence Doubling Period closer to 10 years79.”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [79]
South Korean IBD prevalence was 42 per 100,000 in 2005, 63.8 per 100,000 in 2010, and 92.8 per 100,000 in 2015.
“Similarly, the prevalence of IBD in South Korea was 42 per 100,000 in 2005 (ref.88), 63.8 per 100,000 in 2010 and 92.8 per 100,000 in 2015 (ref.79).”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [79]
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The four epidemiological stages in the global evolution of inflammatory bowel disease
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- Authors
- Kwak, M. S., Cha, J. M., Lee, H. H., Choi, Y. S., Seo, S. I., Ko, K. J., Park, D. I., Kim, S. H., & Kim, T. J.
- Affiliations
- Kyung Hee University (KR)
- Daehang Hospital (KR)
- Hallym University (KR)
- Kangbuk Samsung Hospital (KR)
- Veterans Health Service Medical Center (KR)
- Samsung Medical Center (KR)
- Corresponding author
- Cha, Jae Myung
- ORCID
- Venue
- Journal of Gastroenterology and Hepatology
- Publisher
- Wiley
- Published
- 2018-12-10
- Volume
- 34
- Issue
- 6
- Pages
- 1018-1026
- ISSN
- 0815-9319 (ISSN-L)
- 1440-1746
- OpenAlex
- W2901753975
- Cited by
- 81
- References
- 29
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 11 · 2023: 13 · 2022: 18 · 2021: 19 · 2020: 8 · 2019: 3
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Ministry of Science, ICT and Future Planning (NRF‐2017R1E1A1A01076359)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, IBD prevalence, IBD incidence, health insurance claims data, ICD-10 codes, age distribution of disease, South Korea
- MeSH terms
- Adult, Age Factors, Colitis, Ulcerative, Crohn Disease, Female, Humans, Insurance Claim Review, Male, Middle Aged, Sex Factors, Time Factors, Inflammatory Bowel Diseases, Incidence, Prevalence, Cost of Illness, International Classification of Diseases, Republic of Korea
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