Faecalibacterium prausnitzii Is Associated With Clinical Response to Immune Checkpoint Inhibitors in Patients With Advanced Gastric Adenocarcinoma: Results of Microbiota Analysis of PRODIGE 59-FFCD 1707-DURIGAST Trial
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of stools, HER2 status, primary tumor site, tumor subtype, combined positive score PD-L1, and tumor proportion score PD-L1.P values were then adjusted using the Benjamini-Hochberg P value correction method.
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F. prausnitzii or Lactobacillus rhamnosus restored ICB responses in the context of antibiotic-induced microbiota perturbation.
“Other probiotics like F. prausnitzii (Bredon et al., 2024) or Lactobacillus rhamnosus (Gao et al., 2021) restored ICB responses in the context of antibiotic-induced microbiota perturbation.”
From Microbiota-centered interventions to boost immune checkpoint blockade therapies (2025) · cites this paper as Bredon et al., 2024
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Sorted by citations
Microbiota-centered interventions to boost immune checkpoint blockade therapies
Almonte, A. A., Thomas, S., & Zitvogel, L. (2025) · Journal of Experimental Medicine · doi:10.1084/jem.20250378 · Cited by 19 · see citing works
- Authors
- Bredon, M., le Malicot, K., Louvet, C., Evesque, L., Gonzalez, D., Tougeron, D., & Sokol, H.
- Affiliations
- Inserm (FR)
- Institute Mutualiste Montsouris (FR)
- Centre Antoine Lacassagne (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Corresponding author
- Tougeron, David
- Sokol, Harry
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2025-03
- Volume
- 168
- Issue
- 3
- Pages
- 601-603.e2
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W4403695833
- Cited by
- 14
- References
- 13
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Update notices
- erratum (2025-09-01)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gastroenterology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- Funders
- Sorbonne Université
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Keywords
- Faecalibacterium prausnitzii, immune checkpoint inhibitors, advanced gastric adenocarcinoma, gut microbiota, clinical response, PD-L1 expression, tumor proportion score, HER2 status
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