The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Rituximab: Mechanism of Action
Open accessAbstract
Rituximab is a mainstay in the therapy for a broad variety of B-cell malignancies. Despite its undeniable therapeutic value, we still do not fully understand the mechanisms of action responsible for rituximab's anti-tumor effects. Direct signaling, complement dependent cellular cytotoxicity and antibody dependent cellular cytotoxicity all appear to play a role in rituximab efficacy. In vitro, animal model and clinical data addressing each of these mechanisms of action are reviewed, as are data speaking to the complexity of interactions between these mechanisms. Taken together, these data suggest different mechanisms are likely important in different scenarios. Study of the complex mechanisms of action that contribute to the clinical efficacy of rituximab have led to novel clinical trials including novel combinations, schedules, and generation of additional antibodies designed to have even greater effect. Such studies need to be accompanied by rigorous correlative analysis if we are to understand the importance of various mechanisms of action of rituximab and use that information to improve on what is already an indispensable approach to therapy.
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Metadata
- Authors
- Weiner, G. J.
- Venue
- Seminars in Hematology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 47
- Issue
- 2
- Pages
- 115-123
- ISSN
- 0037-1963 (ISSN-L)
- OpenAlex
- W2133205391
- Cited by
- 786
- References
- 65
- FWCI
- 20.00
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
