Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran
Abstract
During past 3 decades, nuclear medicine has flourished as vibrant and independent medical specialty in Iran. Since that time, more than 200 nuclear physicians have been trained and now practicing in nearly 158 centers throughout the country. In the same period, Tc-99m generators and variety of cold kits for conventional nuclear medicine were locally produced for the first time. Local production has continued to mature in robust manner while fulfilling international standards. To meet the ever-growing demand at the national level and with international achievements in mind, work for production of other Tc-99m-based peptides such as ubiquicidin, bombesin, octreotide, and more recently a kit formulation for Tc-99m TRODAT-1 for clinical use was introduced. Other than the Tehran Research Reactor, the oldest facility active in production of medical radioisotopes, there is one commercial and three hospital-based cyclotrons currently operational in the country. I-131 has been one of the oldest radioisotope produced in Iran and traditionally used for treatment of thyrotoxicosis and differentiated thyroid carcinoma. Since 2009, (131)I-meta-iodobenzylguanidine has been locally available for diagnostic applications. Gallium-67 citrate, thallium-201 thallous chloride, and Indium-111 in the form of DTPA and Oxine are among the early cyclotron-produced tracers available in Iran for about 2 decades. Rb-81/Kr-81m generator has been available for pulmonary ventilation studies since 1996. Experimental production of PET radiopharmaceuticals began in 1998. This work has culminated with development and optimization of the high-scale production line of (18)F-FDG shortly after installation of PET/CT scanner in 2012. In the field of therapy, other than the use of old timers such as I-131 and different forms of P-32, there has been quite a significant advancement in production and application of therapeutic radiopharmaceuticals in recent years. Application of (131)I-meta-iodobenzylguanidine for treatment of neuroblastoma, pheochromocytoma, and other neuroendocrine tumors has been steadily increasing in major academic university hospitals. Also (153)Sm-EDTMP, (177)Lu-EDTMP, (90)Y-citrate, (90)Y-hydroxyapatite colloid, (188/186)Re-sulfur colloid, and (188/186)Re-HEDP have been locally developed and now routinely available for bone pain palliation and radiosynovectomy. Cu-64 has been available to the nuclear medicine community for some time. With recent reports in diagnostic and therapeutic applications of this agent especially in the field of oncology, we anticipate an expansion in production and availability. The initiation of the production line for gallium-68 generator is one of the latest exciting developments. We are proud that Iran would be joining the club of few nations with production lines for this type of generator. There are also quite a number of SPECT and PET tracers at research and preclinical stage of development preliminarily introduced for possible future clinical applications. Availability of fluorine-18 tracers and gallium-68 generators would no doubt allow rapid dissemination of PET/CT practices in various parts of our large country even far from a cyclotron facility. Also, local production and availability of therapeutic radiopharmaceuticals are going to open exciting horizons in the field of nuclear medicine therapy. Given the available manpower, local infrastructure of SPECT imaging, and rapidly growing population, the production of Tc-99m generators and cold kit would continue to flourish in Iran.
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Combining nanocarriers with disease-targeting ligands allows radiotracers to uniformly navigate biological systems, providing insights into cellular processes.
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From Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation (2024) · cites this paper as [64]
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Self-citationGholipour, N., Jalilian, A. R., Khalaj, A., Johari-Daha, F., Yavari, K., Sabzevari, O., Khanchi, A. R., & Akhlaghi, M. (2014) · DARU Journal of Pharmaceutical Sciences · doi:10.1186/2008-2231-22-58 · Cited by 14 · see citing works
Self-citationPaknafas, A., Fazaeli, Y., Jalilian, A. R., Ahmadi, A., Feizi, S., Kamali-dehghan, M., Rahiminejad, A., & Khalaj, A. (2013) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
Self-citationProduction and Quality Control of [(67)Ga]-DOTA-trastuzumab for Radioimmunoscintigraphy.
Alirezapour, B., Jalilian, A. R., Bolourinovin, F., & Moradkhani, S. (2013) · Europe PMC (PubMed Central) · Cited by 13 · see citing works
Self-citationDevelopment of 111In labeled insulin for receptor imaging/therapy
Jalilian, A. R., Garousi, J., Akhlaghi, M., & Rowshanfarzad, P. (2009) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-008-7360-y · Cited by 13 · see citing works
Self-citationThick tellurium electrodeposition on nickel-coated copper substrate for 124I production
Sadeghi, M., Dastan, M., Ensaf, M. R., Tehrani, A. A., Tenreiro, C., & Avila, M. (2008) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2008.02.082 · Cited by 13 · see citing works
Jalilian, A. R., Yousefnia, H., Shafaii, K., Novinrouz, A., & Rajamand, A. A. (2012) · Europe PMC (PubMed Central) · Cited by 13 · see citing works
Self-citationVahidfar, N., Jalilian, A. R., Fazaeli, Y., Bahrami‐Samani, A., Beiki, D., & Khalaj, A. (2014) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-014-3113-2 · Cited by 13 · see citing works
Self-citationPreparation, quality control and biodistribution studies of [67Ga]-DOTA-anti-CD20
Jalilian, A. R., Mirsadeghi, L., Hajihosseini, R., & Khorrami, A. K. (2008) · Radiochimica Acta · doi:10.1524/ract.2008.1494 · Cited by 12 · see citing works
Self-citationPreclinical evaluation of [ 111 In]-DOTA-trastuzumab for clinical trials
Jalilian, A. R., Alirezapour, B., Rajabifar, S., Mirzaii, M., Moradkhani, S., Pouladi, M., & Aslani, G. (2014) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.131434 · Cited by 12 · see citing works
Self-citationDevelopment of 153Sm‐folate‐polyethyleneimine‐conjugated chitosan nanoparticles for targeted therapy
Mollarazi, E., Jalilian, A. R., Johari-Daha, F., & Atyabi, F. (2015) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3305 · Cited by 11 · see citing works
Self-citationVakili, A., Jalilian, A. R., Yavari, K., Shirvani‐Arani, S., Khanchi, A., Bahrami‐Samani, A., Salimi, B., & Khorami‐Moghadam, A. (2013) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-013-2426-x · Cited by 11 · see citing works
Self-citationPreparation and evaluation of [201Tl](III)-DTPA complex for cell labeling
Jalilian, A. R., Yari-Kamrani, Y., Kamali-dehghan, M., & Rajabifar, S. (2007) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-007-6938-0 · Cited by 11 · see citing works
Self-citationErfani, M., Shafiei, M., Mazidi, M., & Goudarzi, M. (2013) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2012.1270 · Cited by 11 · see citing works
Development of [103Pd]-2-acetylpyridine 4N-methyl thiosemicarbazone complex for targeted therapy
Jalilian, A. R., Sadeghi, M., Yari-Kamrani, Y., & Ensaf, M. R. (2006) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-006-0212-8 · Cited by 11 · see citing works
Self-citationZolghadri, S., Yousefnia, H., Jalilian, A. R., & Ghannadi‐Maragheh, M. (2015) · PubMed Central · Cited by 11 · see citing works
Self-citationShirvani‐Arani, S., Bahrami‐Samani, A., Meftahi, M., Jalilian, A. R., & Ghannadi‐Maragheh, M. (2013) · Radiochimica Acta · doi:10.1524/ract.2013.1999 · Cited by 11 · see citing works
Self-citationOptimization of the production of [61Cu]Diacetyl-bis(N4-methylthiosemicarbazone) for PET studies
Jalilian, A. R., Sabet, M., Rowshanfarzad, P., Kamali-dehghan, M., Akhlaghi, M., & Mirzaii, M. (2006) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-006-0244-0 · Cited by 11 · see citing works
Self-citationSalouti, M., Babaei, M. H., Rajabi, H., Foroutan, H., Rasaee, M. J., Bitarafan‐Rajabi, A., Mohammadnejad, J., Shafiee, M., Mazidi, M., & Daha, F. J. (2010) · Annals of Nuclear Medicine · doi:10.1007/s12149-010-0434-2 · Cited by 10 · see citing works
Determination of [201Tl]Tl(III) in [201Tl]TlCl solutions using HPLC
Akhlaghi, M., Kamali-dehghan, M., Jalilian, A. R., & Shadanpoor, N. (2007) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2007.07.023 · Cited by 10 · see citing works
Self-citationHakimi, A., Jalilian, A. R., Shirvani‐Arani, S., Abbasian, P., Khoshmaram, V., & Ghannadi‐Maragheh, M. (2014) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-014-3603-2 · Cited by 10 · see citing works
Self-citationSadeghi, M., Ansari, Z., & Kakavand, T. (2012) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-012-1754-6 · Cited by 10 · see citing works
Preparation and evaluation of [67Ga]-DTPA-β-1–24-corticotrophin in normal rats
Jalilian, A. R., Shanehsazzadeh, S., Akhlaghi, M., Garosi, J., Rajabifar, S., & Tavakoli, M. (2008) · Radiochimica Acta · doi:10.1524/ract.2008.1512 · Cited by 10 · see citing works
Self-citationOnishi, H., Matsutomo, N., Kangai, Y., Saho, T., & Amijima, H. (2013) · Europe PMC (PubMed Central) · Cited by 9 · see citing works
Rabie, A., Enayati, R., Yousefnia, H., Jalilian, A. R., Shamsaei, M., Zolghadri, S., Bahrami‐Samani, A., & Hosntalab, M. (2015) · Annals of Nuclear Medicine · doi:10.1007/s12149-015-1014-2 · Cited by 9 · see citing works
Self-citationPRODUCTION OF 99MTC-ANTIMONY SULFIDE COLLOID FOR LYMPHOSCINTIGRAPHY
Shabani, G., Hamzeh, H., & Najafi, R. (2003) · Cited by 9 · see citing works
Dosimetry of 32P radiocolloid for treatment of cystic craniopharyngioma
Sadeghi, M., Moradi, S., Shahzadi, S., & Pourbeigi, H. (2007) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2007.01.018 · Cited by 9 · see citing works
One-step, no-carrier-added, synthesis of a18F-labelled benzodiazepine receptor ligand
Jalilian, A. R., Tabatabai, S. A., Shafiee, A., AFARIDEH, H., Najafi, R., & Bineshmarvasti, M. (2000) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/(sici)1099-1344(200005)43:6 · Cited by 9 · see citing works
Self-citationCyclotron production of 169Yb: a potential radiolanthanide for brachytherapy
Nadi, H., Sadeghi, M., Enferadi, M., & Sarabadani, P. (2011) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-011-1108-9 · Cited by 9 · see citing works
Synthesis of a [18F]labeled chelidonine derivative as a possible antitumor agent
Jalilian, A. R., Seyfi, P., AFARIDEH, H., & Shafiee, A. (2001) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(00)00270-0 · Cited by 9 · see citing works
Self-citationSynthesis and evaluation of a 99mTc‐labeled tubulin‐binding agent for tumor imaging
Erfani, M., Shamsaei, M., Mohammadbaghery, F., & Shirmardi, S. P. (2014) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3200 · Cited by 9 · see citing works
Hamidieh, A. A., Beiki, D., Paragomi, P., Fallahi, B., Behfar, M., Fard‐Esfahani, A., Hosseini, A. S., Shamshiri, A. R., Eftekhari, M., & Ghavamzadeh, A. (2014) · Pediatric Transplantation · doi:10.1111/petr.12271 · Cited by 9 · see citing works
Self-citationYousefnia, H., Jalilian, A. R., Zolghadri, S., Bahrami‐Samani, A., Shirvani‐Arani, S., & Ghannadi‐Maragheh, M. (2010) · PubMed · Cited by 9 · see citing works
Self-citationEVALUATION OF [67GA]CITRATE IN THE DETECTION OF VARIOUS MICROORGANISM INFECTIONS IN ANIMAL MODELS
Jalilian, A. R., Novinrooz, A., Motamedi-Sedeh, F., Moradkhani, S., Rajamand, A. A., & Solati, J. (2009) · Iranian Journal of Nuclear Medicine · Cited by 9 · see citing works
Self-citationShamshirian, D., Erfani, M., Beiki, D., Fallahi, B., & Shafiei, M. (2015) · Annals of Nuclear Medicine · doi:10.1007/s12149-015-0998-y · Cited by 8 · see citing works
Self-citationPreparation of 99mTc-TRODAT-1 with high labeling yield in boiling water bath: A new formulation
Erfani, M., & Shafiei, M. (2014) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2014.01.003 · Cited by 8 · see citing works
Development of 166Ho-pamidronate for bone pain palliation therapy
Fakhari, A., Jalilian, A. R., Yousefnia, H., Johari-Daha, F., Mazidi, M., & Khalaj, A. (2014) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-014-3515-1 · Cited by 8 · see citing works
Self-citationYousefnia, H., Hosseini-Salekdeh, S. L., Jalilian, A. R., Shafaii, K., Pouladian, M., & Mahmoudi, M. (2012) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.98971 · Cited by 8 · see citing works
Self-citationShahzadi, S., Azimi, P., & Parsa, K. (2013) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.4322 · Cited by 8 · see citing works
Vakili, A., Jalilian, A. R., Moghadam, A., Maryam, G. Z., & Salimi, B. (2012) · Journal of Medical Physics · doi:10.4103/0971-6203.103609 · Cited by 8 · see citing works
Self-citationDevelopment of 153 Sm-DTPA-rituximab for radioimmunotherapy
Bahrami‐Samani, A., Ghannadi‐Maragheh, M., Jalilian, A. R., Yousefnia, H., Garousi, J., & Moradkhani, S. (2009) · Nukleonika · Cited by 8 · see citing works
Self-citationDevelopment of an in vivo radionuclide generator by labeling bleomycin with 191Os
Jamre, M., Salek, N., Jalilian, A. R., Moghaddam, L., Shamsaee, M., Mazidi, M., & Ghannadi‐Maragheh, M. (2011) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-011-1288-3 · Cited by 8 · see citing works
Self-citationDevelopment of radiogallium–ethylenecysteamine cysteine complex as a possible renal imaging agent
Jalilian, A. R., Yousefnia, H., Zolghadri, S., Khoshdel, M. R. F., Bolourinovin, F., & Rahiminejad, A. (2010) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-010-0459-y · Cited by 8 · see citing works
Self-citationPreparation and biodistribution assessment of 111 In-BPAMD as a novel agent for bone SPECT imaging
Yousefnia, H., Zolghadri, S., & Jalilian, A. R. (2015) · Radiochimica Acta · doi:10.1515/ract-2015-2391 · Cited by 8 · see citing works
Self-citationPreclinical Evaluation of 68Ga-MAA from Commercial Available 99mTc-MAA Kit.
Shanehsazzadeh, S., Jalilian, A. R., Lahooti, A., Geramifar, P., Beiki, D., Yousefnia, H., Rabiee, A., Mazidi, M., Mirshojaei, S. F., & Maus, S. (2017) · PubMed Central · Cited by 8 · see citing works
Self-citationDevelopment of 62 Zn bleomycin as a possible PET tracer
Jalilian, A. R., Fateh, B., Ghergherehchi, M., Karimian, A., Moradkhani, S., Kamali-dehghan, M., & Tabeie, F. (2005) · Nukleonika · Cited by 7 · see citing works
Self-citationNaderi, M., Zolghadri, S., Yousefnia, H., Ramazani, A., & Jalilian, A. R. (2016) · Europe PMC (PubMed Central) · doi:10.7508/aojnmb.2016.04.004 · Cited by 7 · see citing works
Self-citationProduction and quality control of 66Ga radionuclide
Sabet, M., Rowshanfarzad, P., Jalilian, A. R., Ensaf, M. R., & Rajamand, A. A. (2006) · Nukleonika · Cited by 7 · see citing works
Self-citationJalilian, A. R., Sadeghi, M., & Kamrani, Y. Y. (2006) · Radiochimica Acta · doi:10.1524/ract.2006.94.12.865 · Cited by 7 · see citing works
Self-citationJalilian, A. R., Emami, A., Akhlaghi, M., Kamali-dehghan, M., Shafaii, K., & Moradkhani, S. (2010) · Radiochimica Acta · doi:10.1524/ract.2010.1696 · Cited by 7 · see citing works
Self-citationHassanzadeh, L., Erfani, M., Najafi, R., Shafiei, M., Amini, M., Shafiee, A., & Sadat-Ebrahimi, S. E. (2012) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2012.10.004 · Cited by 7 · see citing works
Naseri, Z. (2011) · Scientia Pharmaceutica · doi:10.3797/scipharm.1011-08 · Cited by 7 · see citing works
Production and quality control of [166Ho]-DOTA-bevacizumab for therapeutic applications
Khorami‐Moghadam, A., Jalilian, A. R., Yavari, K., Bolouri, B., Bahrami‐Samani, A., & Ghannadi‐Maragheh, M. (2012) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-012-1640-2 · Cited by 7 · see citing works
Self-citationDevelopment of 111In DOTMP for dosimetry of bone pain palliation agents
Yousefnia, H., Jalilian, A. R., Zolghadri, S., Mirzaei, A., Bahrami‐Samani, A., Mirzaii, M., & Ghannadi, M. (2015) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-014-3911-6 · Cited by 7 · see citing works
Self-citationJalilian, A. R., Rowshanfarzad, P., & Sabet, M. (2006) · Radiochimica Acta · doi:10.1524/ract.2006.94.2.113 · Cited by 7 · see citing works
Self-citationDirect Technetium radiopharmaceuticals production using a 30MeV Cyclotron.
Jalilian, A. R., Targholizadeh, H., Raeisali, G., Zandi, H., & Kamali-dehghan, M. (2011) · Europe PMC (PubMed Central) · Cited by 7 · see citing works
Self-citationDevelopment of [66Ga]oxine complex; a possible PET tracer
Jalilian, A. R., Rowshanfarzad, P., Sabet, M., Rahiminejad, A., & Rajamand, A. A. (2006) · Nukleonika · Cited by 7 · see citing works
Self-citationDevelopment of (111)In-labeled porphyrins for SPECT imaging.
Sadeghi, S., Mirzaei, M., Rahimi, M., & Jalilian, A. R. (2014) · PubMed Central · Cited by 7 · see citing works
Self-citationYousefnia, H., Jalilian, A. R., Zolghadri, S., & Ghannadi‐Maragheh, M. (2013) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000000018 · Cited by 7 · see citing works
Self-citationDevelopment of a Ga-68 labeled triptorelin analog for GnRH receptor imaging
Zoghi, M., Ниази, А., Jalilian, A. R., Johari-Daha, F., Alirezapour, B., & Ramezanpour, S. (2015) · Radiochimica Acta · doi:10.1515/ract-2015-2443 · Cited by 7 · see citing works
Self-citationJalilian, A. R., Rowshanfarzad, P., Kamrani, Y. Y., Shafaii, K., & Mirzaii, M. (2007) · PubMed · Cited by 7 · see citing works
Self-citationA 99mTc-tricine-HYNIC-labeled Peptide Targeting the Melanocortin-1 Receptor for Melanoma Imaging.
Shamshirian, D., Erfani, M., Beiki, D., Hajiramazanali, M., & Fallahi, B. (2016) · PubMed Central · Cited by 7 · see citing works
Self-citationDevelopment of (177)Lu-phytate Complex for Radiosynovectomy.
Yousefnia, H., Jalilian, A. R., Bahrami‐Samani, A., Mazidi, M., Maragheh, M. G., & Davani, F. A. (2013) · Europe PMC (PubMed Central) · Cited by 7 · see citing works
Self-citationPreclinical evaluation of holmium‐166 labeled anti‐VEGF‐A(Bevacizumab)
Khorami‐Moghadam, A., Bolouri, B., Jalilian, A. R., Bahrami‐Samani, A., Mazidi, S. M., & Alirezapour, B. (2013) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3044 · Cited by 6 · see citing works
Self-citationZolghadri, S., Yousefnia, H., Jalilian, A. R., & Fazaeli, Y. (2015) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502015000200011 · Cited by 6 · see citing works
Self-citationArmaghan, F. E., Beiki, D., Fallahi, B., Reza, M. S. A., Reza, G. M., Nahid, R., Mehrdad, D., Saghari, M., Emami-Ardekani, A., & Eftekhari, M. (2010) · Iranian Journal of Nuclear Medicine · Cited by 6 · see citing works
Self-citationBahrami‐Samani, A., Ghannadi‐Maragheh, M., Jalilian, A. R., & Mazidi, M. (2010) · Radiochimica Acta · doi:10.1524/ract.2010.1713 · Cited by 6 · see citing works
Self-citationDevelopment of radiolabeled radachlorin complex as a possible tumor targeting agent
Fazaeli, Y., Jalilian, A. R., Rezaee, F., Firuzyar, T., Moradkhani, S., Gh, A. B., & Majdabadi, A. (2014) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-014-3645-5 · Cited by 6 · see citing works
Self-citationSadeghpour, H., Jalilian, A. R., Shafiee, A., Akhlaghi, M., Miri, R., & Mirzaei, M. (2008) · Radiochimica Acta · doi:10.1524/ract.2008.1567 · Cited by 6 · see citing works
Self-citationPreparation and biological evaluation of radiogallium labeled glucagon for SPECT imaging
Jalilian, A. R., Jouiaei, M., Doroudi, A., Garousi, J., & Moradkhani, S. (2010) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-010-0555-z · Cited by 6 · see citing works
Self-citationSynthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole
Jalilian, A. R., Rowshanfarzad, P., AFARIDEH, H., Shafiee, A., Sabet, M., Kyoumarsi, M., & Raeisali, G. (2004) · Applied Radiation and Isotopes · doi:10.1016/j.apradiso.2003.11.091 · Cited by 6 · see citing works
Self-citationOptimization of 90 Y-antiCD20 preparation for radioimmunotherapy
Jalilian, A. R., Gholipour, N., Vakili, A., Radfar, E., Bahrami‐Samani, A., Shirvani‐Arani, S., & Ghannadi‐Maragheh, M. (2013) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.113350 · Cited by 6 · see citing works
Self-citationZolghadri, S., Yousefnia, H., AFARIDEH, H., Bahrami‐Samani, A., Jalilian, A. R., & Ghannadi‐Maragheh, M. (2012) · Nuclear Instruments and Methods in Physics Research Section B Beam Interactions with Materials and Atoms · doi:10.1016/j.nimb.2012.11.013 · Cited by 6 · see citing works
Self-citationDevelopment of ga-67 maltolate complex as an imaging agent.
Fazaeli, Y., Jalilian, A. R., Amini, M. M., Majdabadi, A., Rahiminejad, A., Bolourinovin, F., & Pouladi, M. (2012) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Self-citationPreparation and Evaluation of [55Co](II)DTPA for Blood Cell Labeling
Jalilian, A. R., Rowshanfarzad, P., Yari-Kamrani, Y., Sabet, M., & Majdabadi, A. (2009) · The Open Inorganic Chemistry Journal · doi:10.2174/1874098700903010021 · Cited by 6 · see citing works
Self-citation99mTc-Octreotide Uptake in the Uterus and a Subserosal Myoma Mimicking Tumoral Masses
Pirayesh, E., Amoui, M., & Assadi, M. (2014) · Journal of Nuclear Medicine Technology · doi:10.2967/jnmt.113.131581 · Cited by 6 · see citing works
Production, quality control and initial imaging studies of [82mRb]RbCl for PET studies
Rowshanfarzad, P., Jalilian, A. R., Kiyomarsi, M., Sabet, M., Karimian, A., Moradkhani, S., & Mirzaii, M. (2006) · UWA Profiles and Research Repository (UWA) · Cited by 6 · see citing works
Self-citationNaseri, Z., Hakimi, A., Jalilian, A. R., Kharat, A. N., Shirvani‐Arani, S., Bahrami‐Samani, A., & Ghannadi‐Maragheh, M. (2012) · Radiochimica Acta · doi:10.1524/ract.2012.1910 · Cited by 6 · see citing works
Self-citationGholipour, N., Jalilian, A. R., Fazaeli, Y., Sabzevari, O., Moradkhani, S., Bolourinovin, F., & Khalaj, A. (2014) · Radiochimica Acta · doi:10.1515/ract-2013-2196 · Cited by 6 · see citing works
Self-citationSadeghi, R., Nabiev, H., Kakhaki, V. R. D., Momennezhad, M., Rana, T. M., Zakavi, S. R., & Aryana, K. (2010) · Iranian Journal of Nuclear Medicine · Cited by 6 · see citing works
Preparation of [61Cu]DTPA complex as a possible PET tracer
Jalilian, A. R., Rowshanfarzad, P., Sabet, M., & Kamali-dehghan, M. (2006) · UWA Profiles and Research Repository (UWA) · Cited by 5 · see citing works
Self-citationPreparation and biodistribution of 99mTc-IgG-HYNIC in normal rats
Rajabifar, S., Akhlaghi, M., Jalilian, A. R., Bolourinovin, F., Maashkar, B., Talebimehrdar, M., & Ghafouri, M. (2009) · Nukleonika · Cited by 5 · see citing works
Self-citationAghanejad, A., Jalilian, A. R., Fazaeli, Y., Alirezapoor, B., Pouladi, M., Beiki, D., Maus, S., & Khalaj, A. (2014) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2014.05.108 · Cited by 5 · see citing works
Self-citationDevelopment of an 111In-labeled dihydropyridine complex for L-type calcium channel imaging
Firouzyar, T., Jalilian, A. R., Ardestani, M. S., Aboudzadeh, M. R., Fazaeli, Y., Bolourinovin, F., Mirzaii, M., & Khalaj, A. (2014) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-014-3656-2 · Cited by 5 · see citing works
Self-citationDarvishi, S., Ardakani, M. R., Vazan, S., Ghafourian, H., Paknejad, F., & Faregh, A. H. (2012) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-012-1634-0 · Cited by 5 · see citing works
Jalilian, A. R., Bineshmarvasti, M., Rafii, H., AFARIDEH, H., & Shafiee, A. (2001) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.496 · Cited by 5 · see citing works
Self-citationDevelopment of 170Tm‐DOTA‐cetuximab for radioimmunotherapy
Shirvani‐Arani, S., Bahrami‐Samani, A., Jalilian, A. R., Shirvani‐Arani, A., & Ghannadi‐Maragheh, M. (2012) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.1957 · Cited by 5 · see citing works
Self-citationDEVELOPMENT OF A FREEZE-DRIED RADIOPHARMACEUTICAL KIT FOR DOPAMINE TRANSPORTERS IMAGING
Erfani, M., Shafiei, M., Charkhlooie, G. A., & Goudarzi, M. (2015) · Iranian Journal of Nuclear Medicine · Cited by 5 · see citing works
Development of 68Ga ethyl cysteinate dimer for PET studies
Mirzaei, A., Jalilian, A. R., Shabani, G., Fakhari, A., Akhlaghi, M., & Beiki, D. (2015) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-015-4185-3 · Cited by 5 · see citing works
Self-citationPreparation and quality control of166Ho-DTPA-antiCD20 for radioimmunotherapy
Zolghadri, S., Jalilian, A. R., Yousefnia, H., Bahrami‐Samani, A., Shirvani‐Arani, S., & Ghannadi‐Maragheh, M. (2011) · Radiochimica Acta · doi:10.1524/ract.2011.1826 · Cited by 5 · see citing works
Self-citationZolghadri, S., Jalilian, A. R., Yousefnia, H., Bahrami‐Samani, A., Fazaeli, Y., Pouladi, M., Ghannadi‐Maragheh, M., & AFARIDEH, H. (2013) · Radiochimica Acta · doi:10.1524/ract.2013.2042 · Cited by 5 · see citing works
Self-citationDevelopment of 166Ho bleomycin as a possible therapeutic complex
Zolghadri, S., Jalilian, A. R., Yousefnia, H., Bahrami‐Samani, A., Shirvani‐Arani, S., & Ghannadi‐Maragheh, M. (2010) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-010-0589-2 · Cited by 5 · see citing works
Self-citationFakhari, A., Jalilian, A. R., Yousefnia, H., Shanehsazzadeh, S., Bahrami‐Samani, A., Johari-Daha, F., Shafiee-Ardestani, M., & Khalaj, A. (2015) · Molecular Imaging and Radionuclide Therapy · doi:10.4274/mirt.36036 · Cited by 5 · see citing works
Self-citationKhorami‐Moghadam, A., Jalilian, A. R., Yavari, K., Alirezapour, B., Mazidi, M., & Mirzaii, M. (2013) · Radiochimica Acta · doi:10.1524/ract.2013.2053 · Cited by 5 · see citing works
Self-citationPreparation and evaluation of a [66Ga]gallium chitosan complex in fibrosarcoma bearing animal models
Pourjavadi, A., Akhlaghi, M., & Jalilian, A. R. (2011) · Nukleonika · Cited by 4 · see citing works
Self-citationHPLC ANALYSIS OF RADIOGALLIUM LABELED PROTEINS USING A TWO-SOLVENT SYSTEM
Jalilian, A. R., & Akhlaghi, M. (2013) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2012.673210 · Cited by 4 · see citing works
Self-citationProduction and radiochemical separation of no-carrier-added 88Y by liquid-liquid extraction
Sadeghi, M., & Enferadi, M. (2011) · Radiochemistry · doi:10.1134/s106636221105016x · Cited by 4 · see citing works
Jalilian, A. R., Sheikhha, M. H., Mirzaei, M., Aslani, G., & Shafiee, A. (2004) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1023/b:jrnc.0000027112.34870.ea · Cited by 4 · see citing works
Self-citationBiological evaluation of ( 18 F)-nifedipine as a novel PET tracer for L-type calcium channel imaging
Sadeghpour, H., Jalilian, A. R., Akhlaghi, M., Shafiee, A., Mirzaii, M., Miri, R., & Saddadi, F. (2008) · Nukleonika · Cited by 4 · see citing works
Self-citationPreparation, quality control and biodistribution studies of ( 61 Cu)-oxinate for PET tumor imaging
Jalilian, A. R., Zolghadri, S., Faghihi, R., Yousefnia, H., Garousi, J., Shafaii, K., & Bolourinovin, F. (2009) · Nukleonika · Cited by 4 · see citing works
Self-citationProduction of copper-64 diacetyl-bis (N4-methylthiosemicarbazone) for therapeutic purposes
Jalilian, A. R., Sabet, M., Rowshanfarzad, P., Kamali-dehghan, M., Akhlaghi, M., & Mirzaii, M. (2008) · World Journal of Nuclear Medicine · Cited by 4 · see citing works
Self-citationJalilian, A. R., AFARIDEH, H., Najafi, R., Shafiee, A., & Bineshmarvasti, M. (2000) · PubMed · Cited by 4 · see citing works
Self-citationEvaluation of [67Ga]-insulin for insulin receptor imaging.
Jalilian, A. R., Garosi, J., Gholami, E., Akhlaghi, M., Saddadi, F., Bolourinovin, F., & Karimian, A. (2007) · PubMed · Cited by 4 · see citing works
Self-citation放射免疫治療のための 166 Ho-DTPA-坑CD20の調製と品質管理
Zolghadri, S., Jalilian, A. R., Yousefnia, H., Bahrami‐Samani, A., Shirvani‐Arani, S., & Ghannadi‐Maragheh, M. (2011) · Radiochimica Acta · Cited by 4 · see citing works
Self-citationPreparation and preliminary evaluation of [55Co](II)vancomycin
Jalilian, A. R., Yari-Kamrani, Y., Rowshanfarzad, P., Sabet, M., Kamali-dehghan, M., & Majdabadi, A. (2008) · UWA Profiles and Research Repository (University of Western Australia) · doi:10.1016/s1001-8042(09)60017-8 · Cited by 3 · see citing works
Self-citationEVALUATION OF A NEW 99MTC-BOMBESIN ANALOG IN DIFFERENTIATION OF MALIGNANT FROM BENIGN BREAST TUMORS
Beiki, D., Karami, F., Fallahi, B., Kaviani, A., Harirchi, I., Omranipour, R., Erfani, M., Farzanefar, S., Armaghan, F. E., Emami-Ardekani, A., et al. (2015) · Iranian Journal of Nuclear Medicine · Cited by 3 · see citing works
Self-citationDavarpanah, M. R., Nosrati, S. A., Khoshhosn, H. A., Fazlali, M., & Boudani, M. K. (2013) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3099 · Cited by 3 · see citing works
Feasibility and improvement in production of 191Os/191mIr generator by Tehran Research Reactor (TRR)
Salek, N., Jamre, M., Moghaddam, L., Jalilian, A. R., & Shamsaee, M. (2011) · Annals of Nuclear Energy · doi:10.1016/j.anucene.2011.09.019 · Cited by 3 · see citing works
Self-citationSurface Irradiation Damage of 316 Stainless Steel, Vanadium and Molybdenum by Helium Ion Bombardment
Shinno, H., Shiraishi, H., Kimoto, T., & Watanabe, R. (1983) · Journal of Nuclear Science and Technology · doi:10.3327/jnst.20.163 · Cited by 3 · see citing works
Development of 90Y-chitosan as a new agent for radiosynovectomy
Zolghadri, S., Mirzaei, A., Allaf, M. A., Yousefnia, H., & Jalilian, A. R. (2015) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-015-4087-4 · Cited by 3 · see citing works
Self-citationPreparation and Biological Evaluation of a [55Co]-2-Acetylpyridine Thiosemicarbazone
Jalilian, A. R. (2009) · Scientia Pharmaceutica · doi:10.3797/scipharm.0907-04 · Cited by 3 · see citing works
Self-citationDevelopment of 166Ho-phytate Complex for Radiosynovectomy
Jalilian, A. R., Anvari, A., Bahrami‐Samani, A., Mazidi, M., & Ghannadi‐Maragheh, M. (2011) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-010-0048-6 · Cited by 3 · see citing works
Self-citationMoghaddam, B., Jalilian, A. R., Jamre, M., Salek, N., Mazidi, M., & Ghannadi‐Maragheh, M. (2013) · Iranian Journal of Nuclear Medicine · Cited by 3 · see citing works
Self-citationSIMULTANEOUS PRODUCTION AND QUALITY CONTROL OF 73SE AND 75SE RADIOISOTOPES IN A 30 MEV CYCLOTRON
Farzad, P., Jalilian, A. R., & Mahsa, S. (2004) · Cited by 3 · see citing works
Self-citationDYNAMIC DISTRIBUTION OF 67GA-BLEOMYCIN COMPLEX AND CARRIER FREE 67GALLIUM IN NORMAL MICE
Tabeie, F., Bolouri, B., Jalilian, A. R., Mosaffa, N., Rajabi, H., Asli, E. N., Labibi, F., Karimian, A., & Shirazi, B. (2003) · TSpace (University of Toronto) · Cited by 3 · see citing works
Self-citationFiruzyar, T., Jalilian, A. R., Fazaeli, Y., Ardestani, M. S., Aboudzadeh, M. R., & Khalaj, A. (2014) · Radiochimica Acta · doi:10.1515/ract-2014-2260 · Cited by 3 · see citing works
Self-citationJalilian, A. R., & Bineshmarvasti, M. (2005) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-006-0024-x · Cited by 3 · see citing works
Self-citationProduction and Application of Copper Radiopharmaceuticals
Jalilian, A. R., Rowshanfarzad, P., & Sabet, M. (2009) · Current Radiopharmaceuticals · doi:10.2174/1874471010902020092 · Cited by 2 · see citing works
Self-citationJalilian, A. R., Binehshmarvasti, M., Kumar, P., & Wiebe, L. I. (2006) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-006-0167-7 · Cited by 2 · see citing works
Self-citationJalilian, A. R. (2008) · Scientia Pharmaceutica · doi:10.3797/scipharm.0808-13 · Cited by 2 · see citing works
Self-citationPREPARATION AND BIODISTRIBUTION OF [67GA]-LABELEDOXYTOCIN FOR SPECT PURPOSES
Jalilian, A. R., Tajik, M., Zandi, H. G., Garousi, J., & Bolourinovin, F. (2009) · Iranian Journal of radiation research/Iranian journal of radiation research · Cited by 2 · see citing works
Self-citationJalilian, A. R., Farzad, P., Mahsa, S., Mirzaii, M., Sardari, D., Moafian, J., Satari, A., & Ziaii, A. (2005) · Iranian Journal of Nuclear Medicine · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
59 of the 278 references couldn’t be matched to a known paper.
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Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation
Dhoundiyal, S., Srivastava, S., Kumar, S., Singh, G., Ashique, S., Pal, R., Mishra, N., & Taghizadeh-Hesary, F. (2024) · European Journal of Medical Research · doi:10.1186/s40001-023-01627-0 · Cited by 144 · see citing works
“Combining these carriers with disease-targeting ligands creates a unique balance of precision and adaptability, allowing radiotracers to uniformly navigate biological systems, providing unprecedented insights into cellular processes [64].”
BackgroundCurrent status and trends of nuclear energy under carbon neutrality conditions in China
Dong, D., Guan, J., Wang, Z., & Wang, Y. (2024) · Energy · doi:10.1016/j.energy.2024.134253 · Cited by 81 · see citing works
REVIEW ABOUT RADIOPHARMACEUTICALS: PREPARATION, RADIOACTIVITY, AND APPLICATIONS
Alsharif, S. M., ALANAZI, M., Alharthi, F. H. J., QANDIL, D., & Qushawy, M. K. E. (2020) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2020v12i3.37150 · Cited by 28 · see citing works
Volia, M. F., Tereshatov, E. E., Boltoeva, M., & Folden, C. M., III (2020) · New Journal of Chemistry · doi:10.1039/c9nj04879k · Cited by 18 · see citing works
Khorshidi, A. (2023) · Nuclear Engineering and Technology · doi:10.1016/j.net.2023.02.013 · Cited by 16 · see citing works
Eyvazlou, M., Ahangar, A., Rahimi, A., Davarpanah, M. R., Sayyahi, S. S., & Mohebali, M. (2017) · International Journal of Occupational Safety and Ergonomics · doi:10.1080/10803548.2017.1415832 · Cited by 9 · see citing works
Abbasi, M., Ghalandari, N., Farzanefar, S., Aghamollaii, V., Ahmadi, M., Ganji, M., Afarideh, M., Loloee, S., Naseri, M., & Tafakhori, A. (2017) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2017.10.024 · Cited by 8 · see citing works
Hussain, M., Ali, W., Amjed, N., Wajid, A., & Aslam, M. N. (2022) · Radiochimica Acta · doi:10.1515/ract-2022-0012 · Cited by 7 · see citing works
Economic Sanctions on Iran and Nuclear Medicine.
Zakavi, S. R. (2019) · Europe PMC (PubMed Central) · doi:10.22038/aojnmb.2018.36919.1248 · Cited by 7 · see citing works
Effect of Beta Particles Spectrum on Absorbed Fraction in Internal Radiotherapy.
Hashempour, M., Ghorbani, M., Amato, E., & Knaup, C. (2019) · Europe PMC (PubMed Central) · doi:10.22038/aojnmb.2018.11610 · Cited by 6 · see citing works
Benedetto, R., Massicano, A. V. F., Silva, J. J., Boas, C. A. W. V., Mengatti, J., & de Araújo, E. B. (2018) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902017000417039 · Cited by 5 · see citing works
Chromatographic separation of rhenium radioisotopes from irradiated tungsten cyclotron target
Furkina, E. B., Moiseeva, A. N., Алиев, Р. А., Zagryadskiy, V. A., Makoveeva, K. A., Новиков, В. И., & Унежев, В. Н. (2022) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-022-08526-4 · Cited by 5 · see citing works
A Brief Review of Radioactive Materials for Therapeutic and Diagnostic Purposes
Alam, A., Bharti, M., Rao, G. S. N. K., & Sharma, P. K. (2022) · Current Radiopharmaceuticals · doi:10.2174/1874471016666221028110222 · Cited by 4 · see citing works
The impact of gadolinium on the reactor production of 153Sm
Uguru, E. H., Sani, S. F. A., Khandaker, M. U., Rabir, M. H., Moradi, F., Ekpe, J. E., & Bradley, D. A. (2020) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2020.108995 · Cited by 4 · see citing works
Advancing radiopharmaceutical services in Anglophone Africa
Mosima, S. L., Manicum, A.-L. E., & Summers, B. (2026) · Clinical and Translational Imaging · doi:10.1007/s40336-026-00749-9 · Cited by 1 · see citing works
Mekonen, C. S., Rao, A. V. M., & Dessie, Y. A. (2025) · Nuclear Energy and Technology · doi:10.3897/nucet.11.155986 · Cited by 1 · see citing works
Israel, O., & Erbas, B. (2016) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2016.01.012 · Cited by 1 · see citing works
The present status of radiopharmaceuticals in the country.
Jalilian, A. R., & Beiki, D. (2016) · PubMed Central
Self-citationAOJNMB is Indexed in PubMed Central from the First Issue.
Zakavi, S. R. (2017) · PubMed Central · doi:10.22038/aojnmb.2016.8030
Freeman, L. M., & Blaufox, M. D. (2016) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2016.02.001
Current Nuclear Medicine in Jordan
Kasasbeh, N., Al-Muqbel, K. M., Al-Ali, A., Alsyouf, B., A-Risheq, Z. F., Bayyoud, M., Zreiqat, A. A., Al-Monyer, S., Halaseh, M., Al-Taleb, O., et al. (2025) · Clinical nuclear medicine open. · doi:10.1097/nm9.0000000000000037
Diagnostic pharmacology: Drugs that uncover diseases
Saranraj, K., & Chandana, G. P. S. (2025) · National Journal of Pharmacology and Therapeutics · doi:10.4103/njpt.njpt_46_25
- Authors
- Jalilian, A. R., Beiki, D., Hassanzadeh-Rad, A., Eftekhari, A., Geramifar, P., & Eftekhari, M.
- Affiliations
- Nuclear Science and Technology Research Institute (IR)
- Shariati Hospital (IR)
- Surrey Memorial Hospital (CA)
- Corresponding author
- Eftekhari, Mohammad
- Venue
- Seminars in Nuclear Medicine
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 46
- Issue
- 4
- Pages
- 340-358
- ISSN
- 0001-2998 (ISSN-L)
- OpenAlex
- W2403746937
- Cited by
- 22
- References
- 278
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Update notices
- erratum (2016-11-01)
- Open access
- closed
- Locations
- Seminars in Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Physical Sciences › Physics and Astronomy › Radiation › Nuclear Physics and Applications
- Keywords
- radiopharmaceuticals, medical radioisotopes, Iran, iodine-131, gallium-67 citrate, thallium-201, indium-111, 18F-FDG, PET/CT, therapeutic radiopharmaceuticals, radionuclide therapy
- MeSH terms
- Humans, Iran, Radioisotopes, Radiopharmaceuticals
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