Comparison of four different protocols of I-131 therapy for treating single toxic thyroid nodule
Abstract
OBJECTIVE: To compare low and high doses as well as fixed and calculated doses of I-131 in treating toxic thyroid adenoma. METHODS AND PATIENTS: In a prospective study, patients with hyperthyroidism and a single hot thyroid nodule and 24-h radioactive iodine uptake of more than 25% were randomly treated with one of four protocols: fixed low dose (FLD, 481 MBq), fixed high dose (FHD, 832 MBq), calculated low dose (CLD, 3.33-3.70 MBq/g), and calculated high dose (CHD, 6.66-7.4 MBq/g). The patients were asked to visit the endocrinologist 2 and 6 months after treatment and every 6 months thereafter. Clinical exam and laboratory tests were done in all patients during each follow-up. A curative effect was considered as absence of thyroid stimulating hormone suppression (thyroid stimulating hormone>0.3). An analysis of variance test was used for comparison of groups. RESULTS: 97 patients completed the follow-up, eight male, 89 female, with a mean age of 43.3 years (SD=13.4) and mean 24-h radioactive iodine uptake values of 48.07% (SD=14.07). No significant difference was noted in the four groups regarding age, sex ratio, thyroid uptake, and thyroid weight. About 10 months after therapy, cure of hyperthyroidism was higher in CHD group compared with other groups. Hypothyroidism was significantly higher in CHD and FHD groups compared with CLD and FLD groups in all follow-ups. No significant difference was noted in the cure of hyperthyroidism between CLD and FLD groups. Mean radioiodine dose administered in calculated groups was significantly less than fixed dose groups. CONCLUSION: CHD protocol is preferable in old patients with toxic adenoma whereas CLD is more appropriate in young patients.
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Use of a calculated RAI activity allowed for a lower RAI activity to be administered for similar efficacy in the cure of hyperthyroidism in TA.
“Use of a calculated activity allowed for a lower RAI activity to be administered for a similar efficacy in the cure of hyperthyroidism.”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [279]
A randomized trial of 97 patients with TA confirmed that higher RAI activity leads to earlier disappearance of hyperthyroidism and earlier appearance of hypothyroidism.
“This study confirmed previous reports showing an earlier disappearance of hyperthyroidism and earlier appearance of hypothyroidism with higher RAI activity.”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [279]
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Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran
Jalilian, A. R., Beiki, D., Hassanzadeh-Rad, A., Eftekhari, A., Geramifar, P., & Eftekhari, M. (2016) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2016.01.006 · Cited by 22 · see citing works
- Authors
- Zakavi, S. R., Mousavi, Z., & Davachi, B.
- Affiliations
- Mashhad University of Medical Sciences (IR)
- Corresponding author
- Zakavi, Seyed Rasoul
- Venue
- Nuclear Medicine Communications
- Published
- 2009-02
- Volume
- 30
- Issue
- 2
- Pages
- 169-175
- ISSN
- 0143-3636 (ISSN-L)
- OpenAlex
- W2023537069
- Cited by
- 36
- References
- 25
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nuclear Medicine Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mashhad University of Medical Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- radioiodine therapy, iodine-131, toxic adenoma, hyperthyroidism, hot thyroid nodules, fixed dose, dose comparison, TSH suppression, hypothyroidism, elderly patients
- MeSH terms
- Adult, Dose-Response Relationship, Drug, Dose-Response Relationship, Radiation, Drug Administration Schedule, Female, Humans, Iodine Radioisotopes, Male, Thyroid Nodule, Treatment Outcome, Radiopharmaceuticals
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