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Lower risk for alcohol-induced cirrhosis in wine drinkers

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Becker, Ulrik, Grønbæk, Morten, Johansen, Ditte, Sørensen, Thorkild I. A.·2002·Hepatology
DOI 10.1053/jhep.2002.32101
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Abstract

Although there is a well-known relationship between total alcohol intake and future risk for cirrhosis, other factors such as the type of alcohol consumed are sparsely studied. The aim of this study was to assess the effects of wine compared with other types of alcoholic beverages on risk for alcohol-induced cirrhosis. In 3 prospective studies, 30,630 participants from the Copenhagen area were followed-up for a total observation time of 417,325 person-years. Information on weekly intake of beer, wine, and spirits, and sex, age, body mass index, smoking habits, and education was obtained from questionnaires. The primary outcome measures were first admission or death, with alcohol-induced cirrhosis obtained from death certificates and from the National Hospital Discharge Register. Data were analyzed by means of multiplicative Poisson regression models. We confirmed the increasing risk for cirrhosis with increasing alcohol intake. Individuals who drank more than 5 drinks per day had a relative risk of 14 to 20 for developing cirrhosis compared with non- or light drinkers. However, compared with individuals who drank no wine (relative risk set at 1.0), individuals drinking 16% to 30% wine of their total intake had a relative risk of 0.4 (95% confidence limits, 0.3-0.6) and those drinking 51% or more of wine had a relative risk of 0.3 (95% confidence limits, 0.2-0.5) for developing cirrhosis. In conclusion, the results suggest that a high intake of all 3 types of alcohol conveys an increased risk for cirrhosis, but wine drinkers are at a lower risk than beer and spirits drinkers.

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  • Spirits consumption and binge drinking outside meals increase the risk of developing liver cirrhosis compared with other alcohol types and drinking patterns.

    “These two behaviors have been shown to increase the risk of developing liver cirrhosis in comparison with other alcohol types and drinking patterns [65–67].”

    From Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis (2014) · cites this paper as [67]

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Research works printed but not linked: 5

  1. Sørensen TIA. The relationship between alcohol consumption and risk of development of cirrhosis of the liver. Alcologia 1990; 2:121-126.
  2. Appleyard M, Hansen AT, Schnohr P, Jensen G, Nyboe J. The Copenhagen City Heart Study. A book of tables with data from the first examination (1976-78) and a five year follow-up (1981- 83). Scand J Soc Med 1989;170:1-160.
  3. Klatsky AL, Armstrong MA. Alcohol, smoking, coffee, and cir- rhosis. Am J Epidemiol 1992;136:1248-1257.
  4. Klatsky AL, Armstrong MA, Friedman GD. Alcohol and mortal- ity. Ann Intern Med 1992;117:646-654.
  5. Ticca M, Serafini M. Wine, health and dietary modulation of oxidative stress: an up-date. Alcologia 1997;9:185-189.

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Authors
Becker, U., Grønbæk, M., Johansen, D., & Sørensen, T. I. A.
Affiliations
  • Hvidovre Hospital (DK)
  • Copenhagen University Hospital (DK)
Corresponding author
Becker, Ulrik
ORCID
Venue
Hepatology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-04
Volume
35
Issue
4
Pages
868-875
ISSN
0270-9139 (ISSN-L)
DOI
10.1053/jhep.2002.32101
OpenAlex
W2028810695
Cited by
185
References
43
Citations by year
2026: 3 · 2025: 4 · 2024: 6 · 2023: 9 · 2022: 9 · 2021: 5 · 2020: 10 · 2019: 12 · 2018: 8 · 2017: 11 · 2016: 12 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 7
FWCI
3.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Danish National Board of Health
  • The Copenhagen Centre for Prospective Population Studies
  • The Danish National Research Council
  • Danish Epidemiology Science Centre
  • Danish National Research Foundation
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Keywords
alcoholic cirrhosis, wine consumption, beer, alcoholic beverages, alcohol consumption, liver disease risk, drinking patterns
MeSH terms
Adult, Aged, Aged, 80 and over, Alcohol Drinking, Female, Hospitalization, Humans, Liver Cirrhosis, Male, Middle Aged, Prospective Studies, Regression Analysis, Risk Factors, Wine

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