Alcohol as a risk factor for liver cirrhosis: A systematic review and meta‐analysis
Abstract
Introduction and Aims. Alcohol is an established risk factor for liver cirrhosis. It remains unclear, however, whether this relationship follows a continuous dose–response pattern or has a threshold. Also, the influences of sex and end‐point (i.e. mortality vs. morbidity) on the association are not known. To address these questions and to provide a quantitative assessment of the association between alcohol intake and risk of liver cirrhosis, we conducted a systematic review and meta‐analysis of cohort and case–control studies. Design and Methods. Studies were identified by a literature search of Ovid MEDLINE, EMBASE, Web of Science, CINAHL, PsychINFO, ETOH and Google Scholar from January 1980 to January 2008 and by searching the references of retrieved articles. Studies were included if quantifiable information on risk and related confidence intervals with respect to at least three different levels of average alcohol intake were reported. Both categorical and continuous meta‐analytic techniques were used to model the dose–response relationship. Results. Seventeen studies met the inclusion criteria. We found some indications for threshold effects. Alcohol consumption had a significantly larger impact on mortality of liver cirrhosis compared with morbidity. Also, the same amount of average consumption was related to a higher risk of liver cirrhosis in women than in men. Discussion and Conclusions. Overall, end‐point was an important source of heterogeneity among study results. This result has important implications not only for studies in which the burden of disease attributable to alcohol consumption is estimated, but also for prevention. [Rehm J, Taylor B, Mohapatra S, Irving H, Baliunas D, Patra J, Roerecke M. Alcohol as a risk factor for liver cirrhosis: A systematic review and meta‐analysis. Drug Alcohol Rev 2010]
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The dose-response relationship between average volume of alcohol use and liver cirrhosis is exponential, with the curve more pronounced for mortality than for non-fatal morbidity.
“The dose–response relationship between average volume of alcohol use and liver cirrhosis is exponential, with the curve more pronounced for mortality than for non‐fatal morbidity 280.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [280]
Exposure fractions among prevalent liver cirrhosis cases were used as a proxy for population attributable fractions, following the direct method when relative risk is high.
“We used the resulting predicted exposure fractions among prevalent cases as a proxy for PAFs for liver cirrhosis. This follows from the direct method of approximating PAFs:”
From Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis (2014) · cites this paper as [31]
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955 · see citing works
Rehm, J., Mathers, C., Popova, S., Thavorncharoensap, M., Teerawattananon, Y., & Patra, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60746-7 · Cited by 3,870 · see citing works
Self-citationMethods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353 · see citing works
Alcohol consumption and mortality among middle-aged and elderly U.S. adults
Thun, M. J., Peto, R., Lopez, A. D., Monaco, J. H., Henley, S. J., Heath, C. W., & Doll, R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712113372401 · Cited by 1,313 · see citing works
Generalized Least Squares for Trend Estimation of Summarized Dose–response Data
Orsini, N., Bellocco, R., & Greenland, S. (2006) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x0600600103 · Cited by 1,245 · see citing works
The relation between different dimensions of alcohol consumption and burden of disease: an overview
Rehm, J., Baliunas, D., Borges, G. L. G., Graham, K., Irving, H., Kehoe, T., Parry, C. D., Patra, J., Popova, S., Poznyak, V., et al. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02899.x · Cited by 1,174 · see citing works
Self-citationA meta-analysis of alcohol consumption and the risk of 15 diseases
Corrao, G. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2003.11.027 · Cited by 1,077 · see citing works
Rehm, J., Room, R., Graham, K., Monteiro, M., Gmel, G., & Sempos, C. T. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00467.x · Cited by 995 · see citing works
Self-citationPrediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study
Becker, U., Deis, A., Sørensen, T. I. A., Grønbæk, M., Borch‐Johnsen, K., Muller, C. F., Schnohr, P., & Jensen, G. B. (1996) · Hepatology · doi:10.1002/hep.510230513 · Cited by 847 · see citing works
ALCOHOL AND MORTALITY IN BRITISH MEN: EXPLAINING THE U-SHAPED CURVE
Shaper, A. G., Wannamethee, G., & Walker, M. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92890-5 · Cited by 780 · see citing works
INTERNATIONAL GUIDE FOR MONITORING ALCOHOL CONSUMPTION AND RELATED HARM
Desapriya, E., Stockwell, T. R., Doll, R., & Room, R. (2000) · doi:10.13140/rg.2.2.29007.48808 · Cited by 740 · see citing works
Royston, P. J., & Sauerbrei, W. (2008) · Wiley series in probability and statistics · doi:10.1002/9780470770771 · Cited by 719 · see citing works
Alcohol Consumption and Mortality among Women
Fuchs, C. S., Stampfer, M. J., Colditz, G. A., Giovannucci, E. L., Manson, J. E., Kawachi, I. I., Hunter, D. J., Hankinson, S. E., Hennekens, C. H., ROSNER, B. A., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505113321901 · Cited by 704 · see citing works
Manchikanti, L. (2008) · Pain Physician · doi:10.36076/ppj.2008/11/s63 · Cited by 642 · see citing works
Drinking habits as cofactors of risk for alcohol induced liver damage
Bellentani, S., Saccoccio, G., Costa, G., Tiribelli, C., Manenti, F., Sodde, M., Croce’, L. S., Sasso, F., Pozzato, G., Cristianini, G., et al. (1997) · Gut · doi:10.1136/gut.41.6.845 · Cited by 630 · see citing works
Epidemiology of Alcoholic Liver Disease
Mandayam, S., Jamal, M. M., & Morgan, T. R. M. (2004) · Seminars in Liver Disease · doi:10.1055/s-2004-832936 · Cited by 527 · see citing works
Alcohol Drinking and Mortality among Men Enrolled in an American Cancer Society Prospective Study
Boffetta, P., & Garfinkel, L. (1990) · Epidemiology · doi:10.1097/00001648-199009000-00003 · Cited by 474 · see citing works
Biochemical and Molecular Basis of Alcohol-Induced Injury to Liver and Other Tissues
Epstein, F. H., & Lieber, C. S. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812223192505 · Cited by 441 · see citing works
Alcohol as a Risk Factor for Global Burden of Disease
Rehm, J. T., Room, R., Monteiro, M. G., Gmel, G. E., Graham, K., Rehn, N., Sempos, C. T., & Jernigan, D. H. (2003) · European Addiction Research · doi:10.1159/000072222 · Cited by 440 · see citing works
Self-citationCorrao, G., Bagnardi, V., Zambon, A., & Aricò, S. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9410155111.x · Cited by 389 · see citing works
A Recent Perspective on Alcohol, Immunity, and Host Defense
Szabo, G., & Mandrekar, P. (2009) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00842.x · Cited by 387 · see citing works
Klatsky, A. L., FRIEDMAN, G. D., & SIEGELAUB, A. B. (1981) · Annals of Internal Medicine · doi:10.7326/0003-4819-95-2-139 · Cited by 347 · see citing works
Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease
Zakhari, S., & Li, T.-K. (2007) · Hepatology · doi:10.1002/hep.22010 · Cited by 333 · see citing works
CROSS-CULTURAL AND ANTHROPOBIOLOGICAL REFLECTIONS ON AFRICAN UVULECTOMY
Wind, J. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92809-5 · Cited by 317 · see citing works
Ascitic Cirrhosis in Relation to Alcohol Consumption
Péquignot, G., TUYNS, A. J., & Berta, J. L. (1978) · International Journal of Epidemiology · doi:10.1093/ije/7.2.113 · Cited by 268 · see citing works
The costs of substance abuse in Canada 2002
Rehm, J. T., Baliunas, D. O., Brochu, S., Fischer, B., Gnam, W., Patra, J., Popova, S., Sarnocinska-Hart, A., & Taylor, B. (2006) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-95508 · Cited by 239 · see citing works
Self-citationWine, Liquor, Beer, and Mortality
Klatsky, A. L. (2003) · American Journal of Epidemiology · doi:10.1093/aje/kwg184 · Cited by 228 · see citing works
Rehm, J., Irving, H., Ye, Y., Kerr, W. C., Bond, J., & Greenfield, T. K. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn093 · Cited by 215 · see citing works
Self-citationFollow up study of moderate alcohol intake and mortality among middle aged men in Shanghai, China
Yuan, J., Ross, R. K., Gao, Y., Henderson, B. E., & Yu, M. C. (1997) · BMJ · doi:10.1136/bmj.314.7073.18 · Cited by 203 · see citing works
Alcohol and mortality: The Honolulu heart study
Blackwelder, W. C., Yano, K., Rhoads, G. G., Kagan, A., Gordon, T., & Palesch, Y. Y. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90350-2 · Cited by 201 · see citing works
Relation between Average Alcohol Consumption and Disease: An Overview
Gutjahr, E., Gmel, G. E., & Rehm, J. T. (2001) · European Addiction Research · doi:10.1159/000050729 · Cited by 193 · see citing works
Self-citationA prospective study of risk drinking: At risk for what?
Dawson, D. A., Li, T., & Grant, B. F. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.12.007 · Cited by 191 · see citing works
Lower risk for alcohol-induced cirrhosis in wine drinkers
Becker, U., Grønbæk, M., Johansen, D., & Sørensen, T. I. A. (2002) · Hepatology · doi:10.1053/jhep.2002.32101 · Cited by 185 · see citing works
Alcohol and Mortality: A Cohort Study of Male Japanese Physicians
Kono, S., Ikeda, M., Tokudome, S., Nishizumi, M., & Kuratsune, M. (1986) · International Journal of Epidemiology · doi:10.1093/ije/15.4.527 · Cited by 168 · see citing works
Greater Risk of Ascitic Cirrhosis in Females in Relation to Alcohol Consumption
TUYNS, A. J., & Péquignot, G. (1984) · International Journal of Epidemiology · doi:10.1093/ije/13.1.53 · Cited by 167 · see citing works
Alcohol and cirrhosis: dose–response or threshold effect?
Kamper‐Jørgensen, M., Grønbæk, M., Tolstrup, J. S., & Becker, U. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.03.002 · Cited by 156 · see citing works
Gmel, G. E., Gutjahr, E., & Rehm, J. T. (2003) · European Journal of Epidemiology · doi:10.1023/a:1024805021504 · Cited by 153 · see citing works
Self-citation(1975) · Annals of Internal Medicine · doi:10.7326/0003-4819-83-3-444_4 · Cited by 142 · see citing works
Gordon, T., & Doyle, J. T. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114525 · Cited by 129 · see citing works
DRINKING AND MORTALITY: THE FRAMINGHAM STUDY
Gordon, T., & Kannel, W. B. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113879 · Cited by 122 · see citing works
Cytokines--central factors in alcoholic liver disease.
Neuman, M. G. (2003) · PubMed · Cited by 118 · see citing works
Drinking patterns, dependency and life‐time drinking history in alcohol‐related liver disease
Hatton, J., Burton, A., Nash, H., Munn, E., Burgoyne, L., & Sheron, N. (2009) · Addiction · doi:10.1111/j.1360-0443.2008.02493.x · Cited by 114 · see citing works
META-ANALYSIS OF ALCOHOL INTAKE IN RELATION TO RISK OF LIVER CIRRHOSIS
Corrao, G., V, B., Zambon, A., & TORCHIO, P. (1998) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008408 · Cited by 112 · see citing works
Epidemiology of alcoholic liver disease.
Lelbach, W. K. (1976) · PubMed · Cited by 104 · see citing works
Alcohol and breast cancer: A cohort study
Garfinkel, L., Boffetta, P., & Stellman, S. D. (1988) · Preventive Medicine · doi:10.1016/0091-7435(88)90086-2 · Cited by 81 · see citing works
May, S. J., & Bigelow, C. (2005) · Dose-Response · doi:10.2203/dose-response.003.04.004 · Cited by 66 · see citing works
Hockertz, S., Emmend�rffer, A., Scherer, G., Ruppert, T., Daube, H., Tricker, A. R., & Adlkofer, F. X. (1994) · Cell Biology and Toxicology · doi:10.1007/bf00757561 · Cited by 57 · see citing works
Neuman, M. G., Monteiro, M. G., & Rehm, J. T. (2006) · Substance Use & Misuse · doi:10.1080/10826080600846235 · Cited by 55 · see citing works
Self-citationIntake of Beer, Wine and Spirits and Risk of Heavy Drinking and Alcoholic Cirrhosis
Grønbæk, M., Jensen, M. K., Johansen, D., SØRENSEN, T. I. A., & Becker, U. (2004) · Biological Research · doi:10.4067/s0716-97602004000200004 · Cited by 52 · see citing works
Stokkeland, K., Hilm, G., Spak, F., Franck, J., & Hultcrantz, R. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agm135 · Cited by 48 · see citing works
WINE CONSUMPTION IS NOT ASSOCIATED WITH A DECREASED RISK OF ALCOHOLIC CIRRHOSIS IN HEAVY DRINKERS
Pelletier, S. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.6.618 · Cited by 46 · see citing works
Corrao, G. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90032-v · Cited by 41 · see citing works
Female Sex and the Risk of Liver Cirrhosis
Corrao, G., Aricò, S., Zambon, A., Torchio, P., & di Orio, F. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529709002999 · Cited by 39 · see citing works
Taylor, B., & Rehm, J. T. (2005) · Digestive Diseases · doi:10.1159/000090164 · Cited by 33 · see citing works
Self-citationInvited Commentary: Never, or Hardly Ever? It Could Make a Difference
Klatsky, A. L. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn192 · Cited by 20 · see citing works
Moderate Alcohol Consumption and the Gastrointestinal Tract
Taylor, B., Rehm, J. T., & Gmel, G. E. (2005) · Digestive Diseases · doi:10.1159/000090163 · Cited by 19 · see citing works
Self-citationA case-control study on alcohol consumption and the risk of chronic liver disease.
Corrao, G., Aricò, S., Carle, F., Russo, R., GALATOLA, G., Tabone, M., Torchio, P., la Pierre, M. D., & di Orio, F. (1991) · PubMed · Cited by 16 · see citing works
Rehm et al. Respond to "Never, or Hardly Ever?"
Rehm, J. T., Irving, H. M., Ye, Y., Kerr, W. C., Bond, J. C., & Greenfield, T. K. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn195 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Eslam, M., Sanyal, A. J., George, J., Sanyal, A., Neuschwander-Tetri, B., Tiribelli, C., Kleiner, D. E., Brunt, E., Bugianesi, E., Yki-Järvinen, H., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.312 · Cited by 3,286 · see citing works
Global Burden of Disease and the Impact of Mental and Addictive Disorders
Rehm, J., & Shield, K. D. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-0997-0 · Cited by 1,388 · see citing works
Self-citationGrant, B. F., Chou, S. P., Saha, T. D., Pickering, R. P., Kerridge, B. T., Ruan, W. J., Huang, B., Jung, J., Zhang, H., Fan, A., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.2161 · Cited by 1,362 · see citing works
Bennett, J. E., Stevens, G. A., Mathers, C. D., Bonita, R., Rehm, J., Kruk, M. E., Riley, L. M., Dain, K., Kengne, A. P., Chalkidou, K., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31992-5 · Cited by 1,336 · see citing works
Self-citationThe relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204 · see citing works
Self-citationSeitz, H. K., Bataller, R., Cortez-Pinto, H., Gao, B., Gual, A., Lackner, C., Mathurin, P., Mueller, S., Szabo, G., & Tsukamoto, H. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0014-7 · Cited by 1,271 · see citing works
The relation between different dimensions of alcohol consumption and burden of disease: an overview
Rehm, J., Baliunas, D., Borges, G. L. G., Graham, K., Irving, H., Kehoe, T., Parry, C. D., Patra, J., Popova, S., Poznyak, V., et al. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02899.x · Cited by 1,174 · see citing works
Self-citationLiver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis
Mokdad, A. A., Lopez, A. D., Shahraz, S., Lozano, R., Mokdad, A. H., Stanaway, J., Murray, C. J., & Naghavi, M. (2014) · BMC Medicine · doi:10.1186/s12916-014-0145-y · Cited by 1,129 · see citing works
Erol, A., & Karpyak, V. M. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.08.023 · Cited by 1,022 · see citing works
Global burden of alcoholic liver diseases
Rehm, J., Samokhvalov, A. V., & Shield, K. D. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.007 · Cited by 740 · see citing works
Self-citationEASL Clinical Practical Guidelines: Management of Alcoholic Liver Disease
European Association for the Study of the Liver (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.004 · Cited by 720 · see citing works
ESPEN guideline on clinical nutrition in liver disease
Plauth, M., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Bischoff, S. C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.12.022 · Cited by 674 · see citing works
Chronic diseases and conditions related to alcohol use
Shield, K. (2013) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v35.2.06 · Cited by 488 · see citing works
Kontis, V., Mathers, C. D., Rehm, J., Stevens, G. A., Shield, K. D., Bonita, R., Riley, L. M., Poznyak, V., Beaglehole, R., & Ezzati, M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60616-4 · Cited by 418 · see citing works
Self-citationDiagnosis and Treatment of Alcohol-Associated Liver Disease: A Review
Singal, A. K., & Mathurin, P. (2021) · JAMA · doi:10.1001/jama.2021.7683 · Cited by 398 · see citing works
Alcohol consumption and risk of liver cirrhosis: a systematic review and meta-analysis
Roerecke, M., Vafaei, A., Hasan, O. S. M., Chrystoja, B. R., Cruz, M., Lee, R., Neuman, M. G., & Rehm, J. (2019) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000340 · Cited by 391 · see citing works
Self-citationESPEN practical guideline: clinical nutrition in liver disease
Bischoff, S. C., Bernal, W., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., & Plauth, M. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.09.001 · Cited by 383 · see citing works
Alcohol-associated liver disease
Mackowiak, B., Fu, Y., Maccioni, L., & Gao, B. (2024) · Journal of Clinical Investigation · doi:10.1172/jci176345 · Cited by 359 · see citing works
Alcohol use disorders and mortality: a systematic review and meta-analysis
Roerecke, M., & Rehm, J. (2013) · Addiction · doi:10.1111/add.12231 · Cited by 326 · see citing works
Self-citationÅberg, F., Helenius‐Hietala, J., Puukka, P., Färkkilä, M., & Jula, A. (2018) · Hepatology · doi:10.1002/hep.29631 · Cited by 267 · see citing works
Rehm, J., Kehoe, T., Gmel, G., Stinson, F., Grant, B., & Gmel, G. (2010) · Population Health Metrics · doi:10.1186/1478-7954-8-3 · Cited by 207 · see citing works
Self-citationThe intersection between alcohol-related liver disease and nonalcoholic fatty liver disease
Díaz, L. A., Arab, J. P., Louvet, A., Bataller, R., & Arrese, M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00822-y · Cited by 207 · see citing works
Liver Cirrhosis Mortality in Europe, with Special Attention to Central and Eastern Europe
Zatoński, W. A., Sulkowska, U., Mańczuk, M., Rehm, J., Boffetta, P., Lowenfels, A. B., & La Vecchia, C. (2010) · European Addiction Research · doi:10.1159/000317248 · Cited by 181 · see citing works
Self-citationKhan, A., Tansel, A., White, D. L., Kayani, W. T., Bano, S., Lindsay, J., El-Serag, H. B., & Kanwal, F. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.07.047 · Cited by 179 · see citing works
A narrative review of alcohol consumption as a risk factor for global burden of disease
Rehm, J., & Imtiaz, S. (2016) · Substance Abuse Treatment, Prevention, and Policy · doi:10.1186/s13011-016-0081-2 · Cited by 177 · see citing works
“Thus, it has been found that for liver cirrhosis, the risk curves are steeper (more exponential) for mortality compared to non-fatal outcomes [70].”
BackgroundSelf-citationRisks of light and moderate alcohol use in fatty liver disease: follow-up of population cohorts
Åberg, F., Puukka, P., Salomaa, V., Männistö, S., Lundqvist, A., Valsta, L., Perola, M., Färkkilä, M., & Jula, A. (2020) · Hepatology · doi:10.1002/hep.30864 · Cited by 176 · see citing works
Simpson, R. F., Hermon, C., Liu, B., Green, J., Reeves, G. K., Beral, V., & Floud, S. (2019) · The Lancet Public Health · doi:10.1016/s2468-2667(18)30230-5 · Cited by 154 · see citing works
Alcohol-associated liver disease—Global epidemiology
Åberg, F., Jiang, Z. G., Cortez-Pinto, H., & Männistö, V. (2024) · Hepatology · doi:10.1097/hep.0000000000000899 · Cited by 163 · see citing works
Alcohol Use Disorders in ICD‐11: Past, Present, and Future
Saunders, J. B., Degenhardt, L., Reed, G. M., & Poznyak, V. (2019) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14128 · Cited by 135 · see citing works
Khan, S., Okuda, M., Hasin, D. S., Secades‐Villa, R., Keyes, K., Lin, K., Grant, B., & Blanco, C. (2013) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.12158 · Cited by 121 · see citing works
Reduction of drinking in problem drinkers and all-cause mortality
Rehm, J., & Roerecke, M. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt021 · Cited by 122 · see citing works
Self-citationSex differences in substance use disorders: focus on side effects
Agabio, R., Campesi, I., Pisanu, C., Gessa, G. L., & Franconi, F. (2016) · Addiction Biology · doi:10.1111/adb.12395 · Cited by 117 · see citing works
Remembering the forgotten non-communicable diseases
Lopez, A. D., Williams, T. N., Levin, A., Tonelli, M., Singh, J. A., Burney, P. G., Rehm, J., Volkow, N. D., Koob, G., & Ferri, C. P. (2014) · BMC Medicine · doi:10.1186/s12916-014-0200-8 · Cited by 108 · see citing works
Self-citationFan, A. Z., Chou, S. P., Zhang, H., Jung, J., & Grant, B. F. (2019) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.14192 · Cited by 104 · see citing works
Louvet, A., Bourcier, V., Archambeaud, I., d’Alteroche, L., Chaffaut, C., Oberti, F., Moreno, C., Roulot, D., Dao, T., Moirand, R., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2022.11.013 · Cited by 80 · see citing works
Alcohol and Drug Misuse, Abuse, and Dependence in Women Veterans
Hoggatt, K. J., Jamison, A. L., Lehavot, K., Cucciare, M. A., Timko, C., & Simpson, T. L. (2015) · Epidemiologic Reviews · doi:10.1093/epirev/mxu010 · Cited by 75 · see citing works
Unrecorded alcohol consumption in Russia: toxic denaturants and disinfectants pose additional risks
Solodun, Y., Monakhova, Y., Kuballa, T., Samokhvalov, A., Rehm, J., & Lachenmeier, D. (2011) · Interdisciplinary Toxicology · doi:10.2478/v10102-011-0030-x · Cited by 69 · see citing works
Self-citationHolst, C., Tolstrup, J. S., Sørensen, H. J., & Becker, U. (2017) · Addiction · doi:10.1111/add.13799 · Cited by 61 · see citing works
Åberg, F., Färkkilä, M., & Männistö, V. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14271 · Cited by 63 · see citing works
Alcohol Intake Revisited: Risks and Benefits
Roerecke, M., & Rehm, J. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0277-5 · Cited by 58 · see citing works
Self-citationJoshi, K., Kohli, A., Manch, R., & Gish, R. (2016) · Clinics in Liver Disease · doi:10.1016/j.cld.2016.02.012 · Cited by 58 · see citing works
Stockwell, T., Greer, A., Fillmore, K., Chikritzhs, T., & Zeisser, C. (2012) · BMJ · doi:10.1136/bmj.e2276 · Cited by 53 · see citing works
Management of alcohol use disorder in patients with chronic liver disease
Mellinger, J. L., Fernandez, A. C., & Winder, G. S. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000145 · Cited by 52 · see citing works
Patterns of drinking and liver cirrhosis – What do we know and where do we go?
Rehm, J., & Roerecke, M. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.01.027 · Cited by 22 · see citing works
Self-citationMethodological quality is underrated in systematic reviews and meta-analyses in health psychology
Oliveras, I., Losilla, J.-M., & Vives, J. (2017) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2017.05.002 · Cited by 15 · see citing works
- Authors
- REHM, J., TAYLOR, B., MOHAPATRA, S., IRVING, H., BALIUNAS, D., PATRA, J., & ROERECKE, M.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- REHM, JÜRGEN
- Venue
- Drug and Alcohol Review
- Publisher
- Wiley
- Published
- 2010-07
- Volume
- 29
- Issue
- 4
- Pages
- 437-445
- ISSN
- 0959-5236 (ISSN-L)
- 1465-3362
- OpenAlex
- W1538418689
- Cited by
- 668
- References
- 60
- Citations by year
- 2026: 25 · 2025: 32 · 2024: 48 · 2023: 46 · 2022: 66 · 2021: 60 · 2020: 54 · 2019: 51 · 2018: 58 · 2017: 36 · 2016: 34 · 2015: 43 · 2014: 35 · 2013: 37 · 2012: 17
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug and Alcohol Review (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Keywords
- alcohol consumption, liver cirrhosis, dose-response relationship, threshold effects, sex differences, cirrhosis mortality, alcohol-related disease burden, alcohol prevention
- MeSH terms
- Alcohol Drinking, Alcoholism, Animals, Female, Humans, Liver Cirrhosis, Liver Cirrhosis, Alcoholic, Male, Risk Factors, Cohort Studies, Case-Control Studies, Endpoint Determination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
