The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response
Abstract
On the basis of cross-sectional studies, it has been proposed that hepatic steatosis is a cytopathic effect of hepatitis C virus (HCV) genotype 3 but not genotype 1 infections. We tested this hypothesis by examining whether antiviral treatment altered hepatic steatosis in chronic hepatitis C. In 28 patients with genotype 1 and 34 with genotype 3 HCV, we determined the severity of steatosis in pre- and posttreatment liver biopsies using computer-assisted morphometric image analysis as well as conventional semiquantitative scoring. Before treatment, hepatic steatosis was present in 16 (57%) patients infected with HCV genotype 1 and 21 (62%) of those with genotype 3. Sustained viral response (SVR) was achieved in 9 (32%) patients with genotype 1 and 22 (65%) with genotype 3. In neither group were there significant changes in body weight or alcohol consumption between pre- and posttreatment biopsies. In patients with HCV genotype 1, there was no change in hepatic steatosis after treatment, irrespective of the treatment response. Among those infected with genotype 3, SVR significantly reduced steatosis ( P < .001), but there was no change in steatosis among those without a SVR. By logistic regression analysis, SVR was the only variable predictive of improvement in hepatic steatosis (OR = 36, 95% CI = 2.7-481, P = .007). In conclusion, these data provide strong support for a direct causal association between HCV genotype 3 infection and hepatic steatosis.
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Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions
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Classification of chronic viral hepatitis: a need for reassessment
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Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor
Agnello, V., Ábel, G., Elfahal, M., Knight, G. B., & Zhang, Q.-X. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12766 · Cited by 974
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Fibrosis in Chronic Hepatitis C Correlates Significantly With Body Mass Index and Steatosis
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Etiopathogenesis of Nonalcoholic Steatohepatitis
Chitturi, S., & Farrell, G. C. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-12927 · Cited by 661
Self-citationBarba, G., Harper, F., Harada, T., Kohara, M., Goulinet, S., Matsuura, Y., Eder, G., Schaff, Z., Chapman, M. J., Miyamura, T., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1200 · Cited by 658
Hepatitis C virus core protein induces hepatic steatosis in transgenic mice.
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Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3
Rubbia-Brandt, L., Quadri, R., Abid, K., Giostra, E., Malé, P.-J., Mentha, G., Spahr, L., Zarski, J.-P., Borisch, B., Hadengue, A., et al. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80166-x · Cited by 593
Cited by
Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664
Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression
Hui, J. M., Sud, A., Farrell, G. C., Bandara, P., Byth, K., Kench, J. G., McCaughan, G. W., & George, J. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.032 · Cited by 718
Self-citationSteatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease
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Korenaga, M., Wang, T., Li, Y., Showalter, L. A., Chan, T., Sun, J., & Weinman, S. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506412200 · Cited by 428
PNPLA3 I148M polymorphism and progressive liver disease
Dongiovanni, P. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i41.6969 · Cited by 252
Metadata
- Authors
- Kumar, D., Farrell, G. C., Fung, C., & George, J.
- Venue
- Hepatology
- Published
- 2002-11
- Volume
- 36
- Issue
- 5
- Pages
- 1266-1272
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2005346484
- Cited by
- 379
- References
- 18
- FWCI
- 16.45
- Type
- journal article
- Language
- en
- Open access
- closed
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