PNPLA3 I148M polymorphism and progressive liver disease

Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal

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EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection

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Nonalcoholic Fatty Liver Disease

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Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

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Prevalence of and Risk Factors for Hepatic Steatosis in Northern Italy

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Steatosis Accelerates the Progression of Liver Damage of Chronic Hepatitis C Patients and Correlates With Specific Hcv Genotype and Visceral Obesity

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Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

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Hereditary Hemochromatosis — A New Look at an Old Disease

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Mechanisms of hepatic fibrogenesis

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Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

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Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

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Intestinal microbiota in patients with nonalcoholic fatty liver disease

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Homozygosity for the patatin‐like phospholipase‐3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease†

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A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

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Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects.

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Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3

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The Association of Genetic Variability in Patatin-Like Phospholipase Domain-Containing Protein 3 (PNPLA3) with Histological Severity of Nonalcoholic Fatty Liver Disease†

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Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus

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Heritability of Nonalcoholic Fatty Liver Disease

Schwimmer, J. B., Celedon, M. A., Lavine, J. E., Salem, R. M., Campbell, N. V., Schork, N. J., Shiehmorteza, M., Yokoo, T., Chavez, A. D., Middleton, M. S., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.050 · Cited by 464 · see citing works

Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

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Variant in PNPLA3 is associated with alcoholic liver disease

Tian, C., Stokowski, R. P., Kershenobich, D., Ballinger, D. G., & Hinds, D. A. (2009) · Nature Genetics · doi:10.1038/ng.488 · Cited by 435 · see citing works

Journal of Lipid Research

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Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease

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From Fat to Inflammation

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A feed-forward loop amplifies nutritional regulation of PNPLA3

Huang, Y., He, S., Li, J. Z., Seo, Y.-K., Osborne, T. F., Cohen, J. C., & Hobbs, H. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003585107 · Cited by 386 · see citing works

Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response

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A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severity

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Ethnic differences in hepatic steatosis

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PNPLA3 Variants Specifically Confer Increased Risk for Histologic Nonalcoholic Fatty Liver Disease But Not Metabolic Disease†,‡

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Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol

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Adiponutrin Functions as a Nutritionally Regulated Lysophosphatidic Acid Acyltransferase

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Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro

Pirazzi, C., Adiels, M., Burza, M. A., Mancina, R. M., Levin, M. C., Ståhlman, M., Taskinen, M., Orho‐Melander, M., Perman, J., Pujia, A., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.07.030 · Cited by 300 · see citing works

Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds

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Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

Stickel, F., Buch, S., Lau, K., zu Schwabedissen, H. E. M., Berg, T., Ridinger, M., Rietschel, M., Schafmayer, C., Braun, F., Hinrichsen, H. M., et al. (2010) · Hepatology · doi:10.1002/hep.24017 · Cited by 291 · see citing works

I148M Patatin-Like Phospholipase Domain-Containing 3 Gene Variant and Severity of Pediatric Nonalcoholic Fatty Liver Disease

Valenti, L. V. C., Alisi, A., Galmozzi, E., Bartuli, A., Menico, B. D., Alterio, A., Dongiovanni, P., Fargion, S. R., & Nobili, V. (2010) · Hepatology · doi:10.1002/hep.23823 · Cited by 288 · see citing works

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

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Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis

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Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients

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Variant in the glucokinase regulatory protein ( GCKR ) gene is associated with fatty liver in obese children and adolescents

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Patatin-Like Phospholipase Domain-Containing 3 I148M Polymorphism, Steatosis, and Liver Damage in Chronic Hepatitis C σ

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Relationship of steatosis grade and zonal location to histological features of steatohepatitis in adult patients with non-alcoholic fatty liver disease

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Patatin-Like Phospholipase Domain-Containing 3/Adiponutrin Deficiency in Mice Is Not Associated with Fatty Liver Disease†,‡

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Host- and disease-specific factors affecting steatosis in chronic hepatitis C

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Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

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Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment

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Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B

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A Common Variant in the Patatin-Like Phospholipase 3 Gene ( PNPLA3 ) Is Associated with Fatty Liver Disease in Obese Children and Adolescents

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Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan

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Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

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Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent

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Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption

Davis, J. N., Lê, K., Walker, R. W., Vikman, S., Spruijt‐Metz, D., Weigensberg, M. J., Allayee, H., & Goran, M. I. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.30185 · Cited by 204 · see citing works

Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C

Trépo, E., Pradat, P., Potthoff, A., Momozawa, Y., Quertinmont, E., Gustot, T., Lemmers, A., Berthillon, P., Amininejad, L., Chevallier, M., et al. (2011) · Hepatology · doi:10.1002/hep.24350 · Cited by 176 · see citing works

Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease

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Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease

Dongiovanni, P., Valenti, L. V. C., Rametta, R., Daly, A. K., Nobili, V., Mozzi, E., Leathart, J. B. S., Pietrobattista, A., Burt, A. D., Maggioni, M., et al. (2010) · Gut · doi:10.1136/gut.2009.190801 · Cited by 170 · see citing works

A 360-degree overview of paediatric NAFLD: Recent insights

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The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life

Romeo, S., Sentinelli, F., Cambuli, V. M., Incani, M., Congiu, T., Matta, V., Pilia, S., Huang‐Doran, I., Cossu, E., Loche, S., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.02.034 · Cited by 160 · see citing works

Genetic determinants of alcoholic liver disease

Stickel, F., & Hampe, J. (2011) · Gut · doi:10.1136/gutjnl-2011-301239 · Cited by 150 · see citing works

Association Between Variants in or Near PNPLA3, GCKR, and PPP1R3B With Ultrasound-Defined Steatosis Based on Data From the Third National Health and Nutrition Examination Survey

Hernáez, R., McLean, J., Lazo, M., Brancati, F. L., Hirschhorn, J. N., Borecki, I. B., Harris, T. B., Nguyen, T. T., Kamel, I. R., Bonekamp, S., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.011 · Cited by 145 · see citing works

Genetic factors contribute to variation in serum alanine aminotransferase activity independent of obesity and alcohol: A study in monozygotic and dizygotic twins

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Retinoic acids and hepatic stellate cells in liver disease

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PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence

Falleti, E., Fabris, C., Cmet, S., Cussigh, A., Bitetto, D., Fontanini, E., Fornasiere, E., Bignulin, S., Fumolo, E., Bignulin, E., et al. (2011) · Liver International · doi:10.1111/j.1478-3231.2011.02534.x · Cited by 118 · see citing works

PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals

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Viral genotype-specific role of PNPLA3 , PPARG , MTTP, and IL28B in hepatitis C virus-associated steatosis

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Hepatic Fat Accumulation Is Modulated by the Interaction between the rs738409 Variant in the PNPLA3 Gene and the Dietary Omega6/Omega3 PUFA Intake

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Genome-Wide Association Studies: Results from the First Few Years and Potential Implications for Clinical Medicine

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Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis

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A Common Variant in the PNPLA3 Gene is a Risk Factor for Non-Alcoholic Fatty Liver Disease in Obese Taiwanese Children

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Hepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infection

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Evidence for a Substantial Genetic Influence on Biochemical Liver Function Tests: Results from a Population-based Danish Twin Study

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