The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The First 4 Years—Outcome of Children Identified by Newborn Screening for CF in Germany
Abstract
Background Newborn screening (NBS) has been shown to improve cystic fibrosis (CF) disease course and has been widely implemented worldwide. This monocentric study compared children diagnosed by NBS vs. a cohort preceding the implementation of NBS in Germany in 2016 to evaluate ascribed benefits of NBS. Methods We compared all children with confirmed CF diagnosis (n=19, “NBS group”) out of all children presenting with positive NBS at our center after implementation of NBS (n=100) to children diagnosed with CF at our center within 4 years before NBS implementation (n=29, “pre-NBS group”) for outcomes of anthropometry, gastrointestinal and pulmonary disease manifestations and respiratory microbiology. Results Children diagnosed by NBS had a lower incidence of initial difficulty to thrive (15 vs. 41%) and showed higher mean z-scores for Body-Mass-Index (BMI), weight and length at diagnosis and during study period. Children in the pre-NBS group displayed higher proportions of oxygen-dependent pulmonary exacerbations (10 vs. 0%). They show a significantly lower amount of normal bacterial flora (p=0.005) along with a significantly higher number of throat swab cultures positive for Pseudomonas aeruginosa (p=0.0154) in the first year of life. Yet, pulmonary imaging did not reveal less pulmonary morbidity in the NBS group. Conclusions Our results confirm that NBS for CF leads to earlier diagnosis and improves nutritional outcomes in early childhood. Although trajectories of structural lung damage at early age were unaffected by NBS, NBS positive CF patients at preschool age displayed less pulmonary exacerbations and pathological bacteria in throat swabs.
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Schütz et al. showed that early diagnosis and comprehensive treatment significantly improve the quality of life of the child.
“Early diagnosis and comprehensive treatment significantly improve the quality of life of the child, which is confirmed by the results of research published in Klinische Pediatrie by Schütz et al. drawing attention to the importance of screening tests to improve the course of CF in children [28].”
Citations
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Research works printed but not linked: 1
- A Podbielski, 2019, MIQ 24: Atemwegsinfektionen bei Mukoviszidose: Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik
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“drawing attention to the importance of screening tests to improve the course of CF in children [28].”
BackgroundMukoviszidose – eine Erfolgsgeschichte der Kinderheilkunde
Dittrich, A. (2023) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-023-01796-6 · Cited by 2
Self-citationArias, F. P. S., & Ferrer, E. B. (2024) · Malaysian Journal of Nutrition · doi:10.31246/mjn-2022-0111 · Cited by 1
Mukoviszidose – eine Erfolgsgeschichte der Kinderheilkunde
Dittrich, A. (2024) · Zeitschrift für Pneumologie · doi:10.1007/s10405-024-00584-7
Self-citation
Metadata
- Authors
- Schütz, K., Kontsendorn, J., Janzen, N., Fuge, J., Grewendorf, S., Klemann, C., Happle, C., Junge, S., Rudolf, I., Dopfer, C., Sedlacek, L., Renz, D., Hansen, G., & Dittrich, A.-M.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Newborn Screening Laboratory Hannover, Hannover, Hannover, Deutschland
- Corresponding author
- Dittrich, Anna-Maria
- ORCID
- Venue
- Klinische Pädiatrie
- Publisher
- Georg Thieme Verlag KG
- Published
- 2022-01-28
- Volume
- 234
- Issue
- 05
- Pages
- 284-292
- ISSN
- 0300-8630 (ISSN-L)
- 1439-3824
- OpenAlex
- W4225289943
- Cited by
- 5
- References
- 27
- Citations by year
- 2024: 3 · 2023: 2
- FWCI
- 0.81
- Type
- journal article
- Language
- de
- Open access
- closed
- Locations
- Klinische Pädiatrie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- cystic fibrosis, newborn screening, early diagnosis, nutritional outcomes, pulmonary exacerbations, Pseudomonas aeruginosa, respiratory microbiology, lung injury, preschool children, Germany
- MeSH terms
- Child, Child, Preschool, Cystic Fibrosis, Germany, Humans, Infant, Infant, Newborn, Oxygen, Pseudomonas aeruginosa, Neonatal Screening
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