Screening for Gestational Diabetes Mellitus and Pregnancy Outcomes: Results from a Multicentric Study in Tajikistan
Open accessAbstract
The prevalence of gestational diabetes parallels the prevalence of type 2 diabetes mellitus and is associated with adverse pregnancy outcomes. However, these data are not available for many parts of the world. We assessed the prevalence of gestational diabetes and pregnancy outcomes in Tajikistan. This cohort study included 2438 consecutively recruited representative pregnant women from 8 locations in two cities in Tajikistan, in whom an oral glucose tolerance test (75 g, fasting, 1 h, 2 h) was performed during gestational weeks 24–28. Women with known diabetes and twin pregnancies were excluded. Associations between glucose tolerance test results and pregnancy outcomes were examined. According to the WHO 2013 thresholds, 32.4% of women qualified as having gestational diabetes, the vast majority (29.7%) based on an elevated fasting glucose level (5.1–5.6 mmol/L), while only 2.8% had elevated 1- or 2-hour values or met more than one threshold. Women with only elevated fasting glucose (impaired gestational fasting glycemia) had no evidence of adverse pregnancy outcomes, while those with elevated 1- and/or 2-hour values (impaired gestational glucose tolerance) had more pregnancy complications (infection of urinary tract 1.8 vs. 8.8% p<0.001; preeclampsia 0.7 vs. 10.3% p<0.001) and emergency cesarean sections (4.4 vs. 13.2% p=0.002). Neonates from pregnancies with impaired gestational glucose tolerance had lower APGARs, lower birth weights, lower 30 min glucose levels, and a lower probability of being discharged alive (all p<0.05). In conclusion, the formal prevalence of gestational diabetes is high in Tajikistan; however, this does not translate into adverse pregnancy outcomes for women with impaired gestational fasting glycemia.
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In Tajikistan, between September 2015 and November 2017, Pirmatova et al. conducted a cohort study of 2438 pregnant women at 24-28 weeks using WHO 2013 criteria and found GDM rate approximately 32.4%; patients with GDM were older and had higher BMI.
“Referring to the WHO 2013 criteria, the scientists found a very high rate of GDM in Tajikistan which was approximately 32.4%. The patients with GDM were older, and had a higher BMI [207].”
From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [207]
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Evolution of Gestational Diabetes Mellitus across Continents in 21st Century
Dłuski, D. F., Ruszała, M., Rudziński, G., Pożarowska, K., Brzuszkiewicz, K., & Leszczyńska-Gorzelak, B. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192315804 · Cited by 41 · see citing works
- Authors
- Pirmatova, D., Dodkhoeva, M., Hasbargen, U., Flemmer, A. W., Abdusamatzoda, Z., Saburova, K., Salieva, N., Radzhabova, S., & Parhofer, K. G.
- Affiliations
- Tajik State Medical University (TJ)
- LMU Klinikum (DE)
- Ministry of Health and Social Protection of the Population of the Republic of Tajikistan, Shevchenko, Dushanbe, Tajikistan
- Department of Delivery, Khatlon Regional Clinical Hospital named after Buri Vokhidov, Bokhtar, Tajikistan
- Department of Neonatology, State Institution Health Complex «Istiklol», N. Karaboev av. Dushanbe, Tajikistan
- Department of Reproductive Health, City Health Center, Dushanbe, Tajikistan
- Corresponding author
- Parhofer, Klaus G.
- Venue
- Experimental and Clinical Endocrinology & Diabetes
- Publisher
- Georg Thieme Verlag KG
- Published
- 2022-07-26
- Volume
- 130
- Issue
- 12
- Pages
- 821-827
- ISSN
- 0947-7349 (ISSN-L)
- 1439-3646
- PMC
- PMC9811532
- OpenAlex
- W4288037423
- Cited by
- 2
- References
- 11
- Citations by year
- 2024: 1 · 2022: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Experimental and Clinical Endocrinology & Diabetes (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01DK14022)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- gestational diabetes mellitus, prevalence, pregnancy outcomes, impaired fasting glucose, impaired glucose tolerance, oral glucose tolerance test, preeclampsia, urinary tract infection, emergency cesarean section, neonatal outcomes, birth weight, Apgar score, Tajikistan
- MeSH terms
- Blood Glucose, Diabetes Mellitus, Type 2, Female, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Tajikistan, Cohort Studies, Diabetes, Gestational, Glucose Intolerance
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