Cited by 342Alcohol Consumption and Health EffectsAntioxidant Activity and Oxidative StressDrug-Induced Hepatotoxicity and Protection

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Oxidative Stress and Alcoholic Liver Disease

Wu, Defeng, Cederbaum, Arthur·2009·Seminars in Liver Disease

DOI 10.1055/s-0029-1214370

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Abstract

Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated in small amounts during the body's metabolic reactions and can react with and damage complex cellular molecules such as lipids, proteins, or DNA. This review describes pathways involved in ROS formation, why ROS are toxic to cells, and how the liver protects itself against ROS. Acute and chronic ethanol treatment increases the production of ROS, lowers cellular antioxidant levels, and enhances oxidative stress in many tissues, especially the liver. Ethanol-induced oxidative stress plays a major role in the mechanisms by which ethanol produces liver injury. Many pathways play a key role in how ethanol induces oxidative stress. This review summarizes some of the leading pathways and discusses the evidence for their contribution to alcohol-induced liver injury.

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Background
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Background
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Background
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Background
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Background
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Self-citation
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Background
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Alcohol Increases Liver Progenitor Populations and Induces Disease Phenotypes in Human IPSC-Derived Mature Stage Hepatic Cells
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The effect of low alcohol consumption during pregnancy on the lipid peroxidation‐antioxidant defense system of women, their alcohol‐exposed infants, and growth, health, and developmental outcomes
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Authors: Wu, D., & Cederbaum, A.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
ORCID: Wu, Defeng
Venue: Seminars in Liver Disease
Publisher: Georg Thieme Verlag KG
Published: 2009-04-22
Volume: 29
Issue: 02
Pages: 141-154
ISSN: 0272-8087 (ISSN-L)
1098-8971
DOI: 10.1055/s-0029-1214370
OpenAlex: W1981280200
Cited by: 342
References: 0
Citations by year: 2026: 11 · 2025: 14 · 2024: 19 · 2023: 19 · 2022: 27 · 2021: 19 · 2020: 19 · 2019: 18 · 2018: 16 · 2017: 23 · 2016: 14 · 2015: 19 · 2014: 29 · 2013: 28 · 2012: 26
FWCI: 15.50
Type: journal article
Language: en
Open access: closed
Locations: Seminars in Liver Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords: oxidative stress, alcoholic liver disease, reactive oxygen species, ethanol-induced liver injury, antioxidant defense, alcohol metabolism, lipid peroxidation, DNA damage, protein oxidation
MeSH terms: Alcohol Drinking, Ethanol, Animals, Antioxidants, Glutathione, Humans, Iron, Kupffer Cells, Liver, Liver Diseases, Alcoholic, Mitochondria, Liver, Reactive Oxygen Species, Oxidative Stress, Cytochrome P-450 CYP2E1, Reactive Nitrogen Species

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Oxidative Stress and Alcoholic Liver Disease

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