The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Lactobacillus Sepsis and Probiotic Therapy in Newborns: Two New Cases and Literature Review
Open accessAbstract
Many term and preterm infants are commonly supplemented with probiotics to prevent adverse effects of antibiotic administration and necrotizing enterocolitis and they are believed to be safe. However, the supplementation with Lactobacillus rhamnosus GG has been associated with the development of sepsis with a cause-effect relationship in six newborns and children. In this study, we report two further cases and discuss the emerging issue of probiotic supplementation safety in neonates. We conclude that physicians must be aware that supplementation with L. rhamnosus GG can cause sepsis in high-risk patients on rare occasions.
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“Our review of the literature (from 1980 to 2023) found 23 cases where the blood isolate from a bacteremic patient was identical to the probiotic strain the patient had been taking.”
From Lactobacillus Bacteremia and Probiotics: A Review (2023) · cites this paper as [11]
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“The source of these infections has sometimes been attributed to the use of Lactobacillus-containing probiotics [9,10,11].”
From Lactobacillus Bacteremia and Probiotics: A Review (2023) · cites this paper as [11]
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Cites
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Agostoni, C. V., Buonocore, G., Carnielli, V. P., Curtis, M. D., Darmaun, D., Decsi, T., Domellöf, M., Embleton, N. D., Fusch, C., Genzel‐Boroviczény, O., et al. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181adaee0 · Cited by 1,485
Probiotic bacteria: safety, functional and technological properties
Saarela, M., Mogensen, G., Fondén, R., Mättö, J., & Mattila-Sandholm, T. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00375-8 · Cited by 1,202
Probiotics for prevention of necrotizing enterocolitis in preterm infants
AlFaleh, K. M., & Anabrees, J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005496.pub4 · Cited by 965
Lactobacillus Sepsis Associated With Probiotic Therapy
Land, M. H., Rouster-Stevens, K., Woods, C. R., Cannon, M. L., Cnota, J., & Shetty, A. K. (2005) · Pediatrics · doi:10.1542/peds.2004-2137 · Cited by 599
Pathogenic relevance of Lactobacillus: A retrospective review of over 200 cases
Cannon, J. P., Lee, T. A., Bolanos, J. T., & Danziger, L. H. (2005) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1253-y · Cited by 478
Salminen, M. K., Tynkkynen, S., Rautelin, H., Saxelin, M., Vaara, M., Ruutu, P., Sarna, S., Valtonen, V., & Järvinen, A. (2002) · Clinical Infectious Diseases · doi:10.1086/342912 · Cited by 419
Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome
Kunz, A. N., Noel, J. M., & Fairchok, M. P. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200404000-00017 · Cited by 319
Probiotics for prevention of necrotizing enterocolitis in preterm infants
AlFaleh, K., & Anabrees, J. (2014) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.1976 · Cited by 293
De Groote, M. A., Frank, D. N., Dowell, E., Glode, M. P., & Pace, N. R. (2005) · Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000154588.79356.e6 · Cited by 284
Research works printed but not linked: 1
- [22]Zbinden A Zbinden R Berger C Arlettaz R Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy Neonatology 2015 107 1 56 59 25402825
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Items 101–106 of 106
Possible Benefits and Risks of Using Probiotics in Neonates
Pammi, M., Patil, M. S., Reber, K. M., & Maheshwari, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-69415-5.00018-7
Oguntoye, M. A., & Ezekiel, O. O. (2024) · Food Chemistry Advances · doi:10.1016/j.focha.2024.100641
Neonatal bacteremia and sepsis
Lawrence, S. M., Wynn, J. L., & Gordon, S. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-79525-8.00015-9
Crews, J. D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-82763-8.00259-4
When probiotics turn deadly: a case of Lacticaseibacillus rhamnosus sepsis in a burn patient
Janák, D., Bakalář, B., Fridrichová, M., Zwinsova, B., Zajíček, R., Lipový, B., & Linhartová, P. B. (2026) · Folia Microbiologica · doi:10.1007/s12223-026-01445-x
Demchenkova, M., Semshchikova, Y. P., Барзунова, Т. В., Kozlov, Y. А., & Savintseva, I. N. (2026) · Clinical Microbiology and Antimicrobial Chemotherapy · doi:10.36488/cmac.2026.2.338-343
Metadata
- Authors
- Coviello C, C., Corsini I, I., Arena, F., Antonelli, A., Rossolini, G., & Dani, C.
- Affiliations
- Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy
- University of Siena (IT)
- University of Florence (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Corresponding author
- Dani, Carlo
- Venue
- American Journal of Perinatology Reports
- Publisher
- Georg Thieme Verlag KG
- Published
- 2015-10-28
- Volume
- 06
- Issue
- 01
- Pages
- e25-e29
- ISSN
- 2157-6998 (ISSN-L)
- 2157-7005
- PMC
- PMC4737628
- OpenAlex
- W2288212279
- Cited by
- 106
- References
- 32
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 4 · 2023: 14 · 2022: 10 · 2021: 20 · 2020: 10 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 7
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- American Journal of Perinatology Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Florence Research (University of Florence) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- Lactobacillus rhamnosus GG, probiotic safety, neonates, neonatal sepsis, probiotic supplementation, antibiotic adverse effects, necrotizing enterocolitis, preterm infants
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