The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Lactobacillus Sepsis and Probiotic Therapy in Newborns: Two New Cases and Literature Review
Open accessAbstract
Many term and preterm infants are commonly supplemented with probiotics to prevent adverse effects of antibiotic administration and necrotizing enterocolitis and they are believed to be safe. However, the supplementation with Lactobacillus rhamnosus GG has been associated with the development of sepsis with a cause-effect relationship in six newborns and children. In this study, we report two further cases and discuss the emerging issue of probiotic supplementation safety in neonates. We conclude that physicians must be aware that supplementation with L. rhamnosus GG can cause sepsis in high-risk patients on rare occasions.
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“Our review of the literature (from 1980 to 2023) found 23 cases where the blood isolate from a bacteremic patient was identical to the probiotic strain the patient had been taking.”
From Lactobacillus Bacteremia and Probiotics: A Review (2023) · cites this paper as [11]
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“The source of these infections has sometimes been attributed to the use of Lactobacillus-containing probiotics [9,10,11].”
From Lactobacillus Bacteremia and Probiotics: A Review (2023) · cites this paper as [11]
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Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Agostoni, C. V., Buonocore, G., Carnielli, V. P., Curtis, M. D., Darmaun, D., Decsi, T., Domellöf, M., Embleton, N. D., Fusch, C., Genzel‐Boroviczény, O., et al. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181adaee0 · Cited by 1,485
Probiotic bacteria: safety, functional and technological properties
Saarela, M., Mogensen, G., Fondén, R., Mättö, J., & Mattila-Sandholm, T. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00375-8 · Cited by 1,202
Probiotics for prevention of necrotizing enterocolitis in preterm infants
AlFaleh, K. M., & Anabrees, J. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005496.pub4 · Cited by 980
Lactobacillus Sepsis Associated With Probiotic Therapy
Land, M. H., Rouster-Stevens, K., Woods, C. R., Cannon, M. L., Cnota, J., & Shetty, A. K. (2005) · Pediatrics · doi:10.1542/peds.2004-2137 · Cited by 599
Pathogenic relevance of Lactobacillus: A retrospective review of over 200 cases
Cannon, J. P., Lee, T. A., Bolanos, J. T., & Danziger, L. H. (2005) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1253-y · Cited by 478
Salminen, M. K., Tynkkynen, S., Rautelin, H., Saxelin, M., Vaara, M., Ruutu, P., Sarna, S., Valtonen, V., & Järvinen, A. (2002) · Clinical Infectious Diseases · doi:10.1086/342912 · Cited by 419
Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome
Kunz, A. N., Noel, J. M., & Fairchok, M. P. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200404000-00017 · Cited by 319
Probiotics for prevention of necrotizing enterocolitis in preterm infants
AlFaleh, K., & Anabrees, J. (2014) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.1976 · Cited by 293
De Groote, M. A., Frank, D. N., Dowell, E., Glode, M. P., & Pace, N. R. (2005) · Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000154588.79356.e6 · Cited by 284
Tynkkynen, S., Satokari, R. M., Saarela, M., Mattila, T., & Saxelin, M. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.9.3908-3914.1999 · Cited by 224
Ohishi, A., Takahashi, S., Ito, Y., Ohishi, Y., Tsukamoto, K., Nanba, Y., Ito, N., Kakiuchi, S., Saitoh, A., Morotomi, M., et al. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.11.041 · Cited by 171
Henry, M. C. W., & Moss, R. L. (2008) · Annual Review of Medicine · doi:10.1146/annurev.med.60.050207.092824 · Cited by 142
Schelonka, R. L., & Infante, A. J. (1998) · Seminars in Perinatology · doi:10.1016/s0146-0005(98)80003-7 · Cited by 140
Lactobacillemia—Report of nine cases
Bayer, A. S., Chow, A. W., Betts, D., & Guze, L. B. (1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90521-1 · Cited by 139
Case Series of Bifidobacterium longum Bacteremia in Three Preterm Infants on Probiotic Therapy
Zbinden, A., Zbinden, R., Berger, C., & Arlettaz, R. (2015) · Neonatology · doi:10.1159/000367985 · Cited by 98
Bifidobacterium septicaemia in an extremely low-birthweight infant under probiotic therapy: Figure 1
Jenke, A. C. W., Ruf, E.-M., Hoppe, T., Heldmann, M., & Wirth, S. (2011) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2011-300838 · Cited by 91
Prevention of Nosocomial Infections in Neonatal Intensive Care Units
Luca, D. D., Stronati, M., Jacqz-Aigrain, É., Ruffinazzi, G., Luparia, M., Tavella, E., Boano, E., Castagnola, E., Mostert, M., Farina, D., et al. (2013) · American Journal of Perinatology · doi:10.1055/s-0032-1333131 · Cited by 83
Lactobacillus acidophilus Sepsis in a Neonate
Thompson, C. A. H., McCarter, Y. S., Krause, P. J., & HERSON, V. C. (2001) · Journal of Perinatology · doi:10.1038/sj.jp.7200509 · Cited by 71
Lactobacillus Species as Opportunistic Pathogens in Immunocompromised Patients
Schlegel, L., Lemerle, S., & Geslin, P. (1998) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s100960050216 · Cited by 69
Late-onset neonatal infections: incidences and pathogens in the era of antenatal antibiotics
Didier, C., Streicher, M.-P., Chognot, D., Campagni, R., Schnebelen, A., Messer, J., Donato, L., Langer, B., Meyer, N., Astruc, D., et al. (2011) · European Journal of Pediatrics · doi:10.1007/s00431-011-1639-7 · Cited by 68
Two Cases of Lactobacillus Bacteremia During Probiotic Treatment of Short Gut Syndrome
Young, R. J., & Vanderhoof, J. A. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200410000-00027 · Cited by 65
Lactobacillus rhamnosus infection in a child following bone marrow transplant
Kalima, P., Masterton, R. G., Roddie, P. H., & Thomas, A. E. (1996) · Journal of Infection · doi:10.1016/s0163-4453(96)91622-9 · Cited by 62
Lactobacillus Sepsis Associated With Probiotic Therapy
Berger, R. E. (2005) · The Journal of Urology · doi:10.1016/s0022-5347(01)68804-9 · Cited by 60
Neonatal meningitis due to Lactobacillus
Broughton, R. A., Gruber, W. C., Haffar, A. A. M., & Baker, C. J. (1983) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198309000-00012 · Cited by 49
Isolation of non-sporing anaerobic rods from infections in children
Brook, I. (1996) · Journal of Medical Microbiology · doi:10.1099/00222615-45-1-21 · Cited by 49
Lactobacillus rhamnosus GG suspected infection in a newborn with intrauterine growth restriction
Sadowska-Krawczenko, I., Paprzycka, M., Korbal, P., Wiatrzyk, A., Krysztopa-Grzybowska, K., Polak, M., Czajka, U., & Lutyńska, A. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0074 · Cited by 41
Isolation of vancomycin-resistant lactobacilli from three neutropenic patients with pneumonia
Sriskandan, S., Lacey, S., & Fischer, L. (1993) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01973653 · Cited by 21
Gaillard, F. (2009) · Radiopaedia.org · doi:10.53347/rid-6355 · Cited by 10
Lactobacillemia—report of nine cases. Important clinical and therapeutic considerations
(1978) · The American Journal of Medicine · doi:10.1016/0002-9343(78)90562-4 · Cited by 9
Bifidobacterium septicaemia in an extremely low-birthweight infant under probiotic therapy
Neu, J. (2012) · Yearbook of Neonatal and Perinatal Medicine · doi:10.1016/j.ynpm.2012.06.021 · Cited by 7
Research works printed but not linked: 1
- [22]Zbinden A Zbinden R Berger C Arlettaz R Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy Neonatology 2015 107 1 56 59 25402825
Cited by
Sorted by citations
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Health Benefits of Heat-Killed (Tyndallized) Probiotics: An Overview
Piqué, N., Berlanga, M., & Miñana-Galbis, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102534 · Cited by 642
(BIOHAZ), E. P. O. B. H., Ricci, A., Allende, A., Bolton, D., Chemaly, M., Davies, R., Gironés, R., Herman, L., Koutsoumanis, K. P., Lindqvist, R., et al. (2017) · EFSA Journal · doi:10.2903/j.efsa.2017.4664 · Cited by 467
Gao, J., Li, Y., Wan, Y., Hu, T., Liu, L., Yang, S., Gong, Z., Zeng, Q., Wei, Y., Yang, W., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00477 · Cited by 311
Probiotics and Preterm Infants
van den Akker, C. H. P., van Goudoever, J. B., Shamir, R., Domellöf, M., Embleton, N. D., Hojsak, I., Lapillonne, A., Mihatsch, W., Canani, R. B., Bronský, J., et al. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002655 · Cited by 239
Metadata
- Authors
- Coviello C, C., Corsini I, I., Arena, F., Antonelli, A., Rossolini, G., & Dani, C.
- Affiliations
- Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy
- University of Siena (IT)
- University of Florence (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Corresponding author
- Dani, Carlo
- Venue
- American Journal of Perinatology Reports
- Publisher
- Georg Thieme Verlag KG
- Published
- 2015-10-28
- Volume
- 06
- Issue
- 01
- Pages
- e25-e29
- ISSN
- 2157-6998 (ISSN-L)
- 2157-7005
- PMC
- PMC4737628
- OpenAlex
- W2288212279
- Cited by
- 106
- References
- 32
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 4 · 2023: 14 · 2022: 10 · 2021: 20 · 2020: 10 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 7
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- American Journal of Perinatology Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Florence Research (University of Florence) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- Lactobacillus rhamnosus GG, probiotic safety, neonates, neonatal sepsis, probiotic supplementation, antibiotic adverse effects, necrotizing enterocolitis, preterm infants
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