Cited by 229Diabetes, Cardiovascular Risks, and LipoproteinsNitric Oxide and Endothelin EffectsMetabolism and Genetic Disorders

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Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

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Dambrova, M., Latkovskis, G., Kuka, J., Strele, I., Konrade, I., Grinberga, S., Hartmane, D., Pugovics, O, Erglis, A., Liepinsh, E.·2016·Experimental and Clinical Endocrinology & Diabetes

DOI 10.1055/s-0035-1569330

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Abstract

Recent studies have revealed strong associations between systemic trimethylamine N-oxide (TMAO) levels, atherosclerosis and cardiovascular risk. In addition, plasma L-carnitine levels in patients with high TMAO concentrations predicted an increased risk for cardiovascular disease and incident major adverse cardiac events. The aim of the present study was to investigate the relation between TMAO and L-carnitine plasma levels and diabetes. Blood plasma samples were collected from 12 and 20 weeks old db/db mice and patients undergoing percutaneous coronary intervention. Diabetic compared to non-diabetic db/L mice presented 10-fold higher TMAO, but lower L-carnitine plasma concentrations at 12 weeks of age. After 8 weeks of observation, diabetic db/db mice had significantly increased body weight, insulin resistance and TMAO concentration in comparison to non-diabetic control. In 191 patients undergoing percutaneous coronary intervention the median (interquartile range) plasma concentration of TMAO was 1.8 (1.2-2.6) µmol/L. Analysis of the samples showed a bivariate association of TMAO level with age, total cholesterol and L-carnitine. The multivariate linear regression analysis revealed that, in addition to L-carnitine as the strongest predictor of log transformed TMAO (p<0.001), the parameters of age, diabetes status and body mass index (BMI) were independently associated with increased log transformed TMAO levels (p<0.01).Our data provide evidence that age, diabetes and BMI are associated with higher TMAO levels independently of L-carnitine. These data support the hypothesis of TMAO as a cardiovascular risk marker and warrant further investigation of TMAO for diabetes research applications.

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Authors: Dambrova, M., Latkovskis, G., Kuka, J., Strele, I., Konrade, I., Grinberga, S., Hartmane, D., Pugovics, O., Erglis, A., & Liepinsh, E.
Affiliations: Latvijas Organiskās Sintēzes Institūts (LV)
Pauls Stradiņš Clinical University Hospital (LV)
Riga Stradins University, Riga, Latvia
Latvian Institute of Organic Synthesis, Riga, Latvia
Paul Stradins Clinical University Hospital, Riga, Latvia
Corresponding author: Dambrova, M.
ORCID: Dambrova, M.
Latkovskis, G.
Kuka, J.
Liepinsh, E.
Venue: Experimental and Clinical Endocrinology & Diabetes
Publisher: Georg Thieme Verlag KG
Published: 2016-04-28
Volume: 124
Issue: 04
Pages: 251-256
ISSN: 0947-7349 (ISSN-L)
1439-3646
DOI: 10.1055/s-0035-1569330
OpenAlex: W2342504128
Cited by: 229
References: 29
Citations by year: 2026: 9 · 2025: 20 · 2024: 24 · 2023: 20 · 2022: 31 · 2021: 30 · 2020: 22 · 2019: 25 · 2018: 25 · 2017: 18 · 2016: 4
FWCI: 24.05
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Experimental and Clinical Endocrinology & Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords: trimethylamine N-oxide, diabetes mellitus, L-carnitine, db/db mice, insulin resistance, cardiovascular risk markers, percutaneous coronary intervention, body mass index, age, atherosclerosis, plasma biomarkers
MeSH terms: Age Factors, Aged, Animals, Cardiovascular Diseases, Carnitine, Diabetes Mellitus, Disease Models, Animal, Female, Humans, Male, Methylamines, Middle Aged, Body Mass Index, Mice

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Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels

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