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Haemostasis in Normal Pregnancy
Abstract
Summary: A study has been undertaken in 72 women to provide systematic information on the changes that occur in a wide range of haemostatic variables during and after pregnancy. Factors VII, VIII :C, VIIIR:Ag, X, fibrinogen and α1 antitrypsin, rose markedly throughout pregnancy. Factors II and V and α2 macroglobulin all rose early on but then decreased steadily. Antithrombin III: C and Ag fell slightly. There was a marked decrease in fibrinolytic activity from 11-15 weeks onwards. Levels of fibrin degradation products rose from 21-25 weeks onwards. The rise in coagulation factors that occurs could be due to increased synthesis or increased activation by thrombin, or to both. The findings are consistent with a mild degree of local intravascular coagulation from early on in pregnancy in some women.
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Citations
Cited by
Rai, R., & Regan, L. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69204-0 · Cited by 1,227
Activated Protein C Sensitivity, Protein C, Protein S and Coagulation in Normal Pregnancy
Brennand, J., Conkie, J. A., McCall, F., Greer, I. A., Walker, I., & Clark, P. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615035 · Cited by 386
Manifestations of chronic disease during pregnancy
Kaaja, R. J. (2005) · JAMA · doi:10.1001/jama.294.21.2751 · Cited by 382
Erez, O., Novack, L., Beer-Weisel, R., Dukler, D., Press, F., Zlotnik, A., Than, N. G., Tomer, A., & Mazor, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093240 · Cited by 146
“In addition, systemic changes are observed in the maternal plasma including : 1) increased concentrations of clotting factors VII, VIII, IX, X and XII [3,9–13] and fibrinogen; 2) a reduction in the concentration of anticoagulant proteins such as protein S and tissue factor pathway inhibitor (TFPI)-1 [14–18]; 3) acquir…”
BackgroundThrombophilia and pregnancy loss
Regan, L., & Rai, R. (2002) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(01)00144-9 · Cited by 69
Metadata
- Authors
- Stirling, Y., Woolf, L., North, W. R. S., Seghatchian, M. J., & Meade, T. W.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1984
- Volume
- 52
- Issue
- 02
- Pages
- 176-182
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2469405187
- Cited by
- 600
- References
- 0
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Haemostasis in Normal Pregnancy. https://app.cochat.ai/papers/10.1055/s-0038-1661167
- The paper
- Stirling, Y., Woolf, L., North, W. R. S., Seghatchian, M. J., & Meade, T. W. (1984). Haemostasis in Normal Pregnancy. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0038-1661167
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
