The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock
Abstract
Summary: The prognostic value of plasminogen activator inhibitor type 1 (PAI-1) in septic shock was investigated in 52 patients with septic shock. The patients had significantly elevated serum PAI-1 levels with respect to the control group (p = 0.002). In patients not having a rapidly fatal underlying disease, PAI-1 was significantly higher in patients dying within a week after onset of shock than in survivors (median PAI-1: 900 and 307 ng/ml, respectively; p = 0.001). The analysis of the distribution of PAI-1 levels permitted retrospectively to determine a threshold level of PAI-1 which had prognostic significance. Mortality was 71% in patients with serum PAI-1 above 550 ng/ml, whereas only two patients (6%) having a PAI-1 below 550 ng/ml died within a week. Thus, in patients with septic shock, PAI-1 appears to have a strong predictive value as to mortality. This early marker may help the clinician in identifying a subgroup of patients particularly at risk.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Cited by
Pierrakos, C., & Vincent, J.-L. (2010) · Critical Care · doi:10.1186/cc8872 · Cited by 1,377
Has the mortality of septic shock changed with time?
Friedman, G., Silva, E., & Vincent, J.-L. (1998) · Critical Care Medicine · doi:10.1097/00003246-199812000-00045 · Cited by 607
The endothelium in sepsis: Source of and a target for inflammation
Hack, C. E., & Zeerleder, S. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107001-00011 · Cited by 295
Low Levels of Protein C Are Associated With Poor Outcome in Severe Sepsis
Yan, S. B., Helterbrand, J. D., Hartman, D. L., Wright, T. J., & Bernard, G. R. (2001) · Chest · doi:10.1378/chest.120.3.915 · Cited by 256
YAMAMOTO, K., TAKESHITA, K., KOJIMA, T., TAKAMATSU, J., & SAITO, H. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.013 · Cited by 214
Metadata
- Authors
- Pralong, G., Calandra, T., Glausef, M.-P., Schellekens, J., Verhoef, J., Bachmann, F., & Kruithof, E. K. O.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1989
- Volume
- 61
- Issue
- 03
- Pages
- 459-462
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W3171197
- Cited by
- 199
- References
- 2
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock. https://app.cochat.ai/papers/10.1055/s-0038-1646614
- The paper
- Pralong, G., Calandra, T., Glausef, M.-P., Schellekens, J., Verhoef, J., Bachmann, F., & Kruithof, E. K. O. (1989). Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0038-1646614
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
