Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

Wright, S. D., Ramos, R., Tobias, P. S., Ulevitch, R. J., & Mathison, J. C. (1990) · Science · doi:10.1126/science.1698311 · Cited by 3,986 · see citing works

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3749 · Cited by 3,374 · see citing works

Obesity and the risk of heart failure

Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093 · see citing works

Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study

Rosengren, A., Hawken, S., Ôunpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., & Yusuf, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17019-0 · Cited by 2,414 · see citing works

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154 · see citing works

Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819 · see citing works

Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00463-3 · Cited by 1,775 · see citing works

Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction

Wilhelmsen, L., Svärdsudd, K., Korsan-Bengtsen, K., Larsson, B., Welin, L., & Tibblin, G. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408233110804 · Cited by 1,645 · see citing works

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

Hamsten, A., Walldius, G., Szamosi, A., Blombäck, M., de Faire, U., Dahlén, G. H., Landou, C., & Wiman, B. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93050-9 · Cited by 1,474 · see citing works

Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction

Hamsten, A., Wiman, B., Fairé, U. D., & Blombäck, M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512193132501 · Cited by 1,339 · see citing works

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305 · see citing works

Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction

Celermajer, D. S., Sørensen, K. E., Bull, C., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90141-4 · Cited by 1,228 · see citing works

The Pathophysiologic Roles of Interleukin-6 in Human Disease

Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146 · see citing works

Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis

Koster, T., Vandenbroucke, J. P., Rosendaal, F. R., Briët, E., Rosendaal, F. R., & Blann, A. D. (1995) · The Lancet · doi:10.1016/s0140-6736(95)90166-3 · Cited by 1,131 · see citing works

Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty

Shimomura, I., Funahasm, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., et al. (1996) · Nature Medicine · doi:10.1038/nm0796-800 · Cited by 890 · see citing works

Plasminogen-Activator Inhibitor Type 1 and Coronary Artery Disease

Kohler, H. P., & Grant, P. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006153422406 · Cited by 805 · see citing works

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

Heymans, S. R. B., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E. E., Moons, L., Dyspersin, G. D., Cleutjens, J. P. M., Shipley, M., Angellilo, A., et al. (1999) · Nature Medicine · doi:10.1038/13459 · Cited by 793 · see citing works

Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.

Eriksson, P. O., Kallin, B., Hooft, F. M. V. '., Båvenholm, P., & Hamsten, A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.6.1851 · Cited by 737 · see citing works

Age-Related Reduction of NO Availability and Oxidative Stress in Humans

Taddei, S., Virdis, A., Ghiadoni, L., Salvetti, G., Bernini, G., Magagna, A., & Salvetti, A. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.274 · Cited by 664 · see citing works

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

Carmeliet, P., Moons, L., Lijnen, R. H., Baes, M. I., Lemaı̂tre, V., Tipping, P. G., Drew, A. F., Eeckhout, Y., Shapiro, S. D., Lupu, F., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-439 · Cited by 660 · see citing works

Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

Loscalzo, J. (2001) · Circulation Research · doi:10.1161/hh0801.089861 · Cited by 612 · see citing works

Matrix Metalloproteinase Inhibition After Myocardial Infarction

Creemers, E. E., Cleutjens, J. P. M., Smits, J. F. M., & Daemen, M. J. A. P. (2001) · Circulation Research · doi:10.1161/hh1501.094396 · Cited by 598 · see citing works

Fibrinolytic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients With Angina Pectoris

Juhan-Vague, I., Pyke, S., Alessi, M., Jespersen, J., Haverkate, F., & Thompson, S. G. (1996) · Circulation · doi:10.1161/01.cir.94.9.2057 · Cited by 551 · see citing works

Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries.

Schneiderman, J., Sawdey, M., Keeton, M., Bordin, G. M., Bernstein, E. F., Dilley, R. B., & Loskutoff, D. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6998 · Cited by 543 · see citing works

Angiotensin II regulates the expression of plasminogen activator inhibitor-1 in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis.

Vaughan, D. E., Lazos, S. A., & Tong, K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117809 · Cited by 528 · see citing works

Promotion and Subsequent Inhibition of Plasminogen Activation after Administration of Intravenous Endotoxin to Normal Subjects

Suffredini, A. F., Harpel, P. C., & Parrillo, J. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198905043201802 · Cited by 486 · see citing works

Associations of Factor VIII and von Willebrand Factor with Age, Race, Sex, and Risk Factors for Atherosclerosis

Conlan, M. G., Folsom, A. R., Finch, A., DAVIS, C. E., Sorlie, P. D., Marcucci, G., Wu, K. K., & For the ARIC Study Investigators (1993) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649589 · Cited by 438 · see citing works

Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.

Sawdey, M., & Loskutoff, D. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115440 · Cited by 413 · see citing works

Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis.

Carmeliet, P., Stassen, J. M., Schoonjans, L., Neugeboren, B. I., van den Oord, J. J., Mol, M. D., Mulligan, R. C., & Collen, D. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116893 · Cited by 388 · see citing works

High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.

Grøndahl-Hansen, J., Christensen, I. J., Rosenquist, C., Brünner, N., Mouridsen, H. T., Danø, K., & Blichert-Toft, M. (1993) · PubMed · Cited by 380 · see citing works

Epidemiological Study on Factor VII, Factor VIII and Fibrinogen in an Industrial Population: I. Baseline Data on the Relation to Age, Gender, Body-Weight, Smoking, Alcohol, Pill-Using, and Menopause

Balleisen, L., Bailey, J., Epping, P.-H., Schulte, H., & van de Loo, J. (1985) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657877 · Cited by 345 · see citing works

Alterations of Nitric Oxide Synthase Expression With Aging and Hypertension in Rats

Chou, T.-C., Yen, M., Li, C., & Ding, Y.-A. (1998) · Hypertension · doi:10.1161/01.hyp.31.2.643 · Cited by 339 · see citing works

Factors Responsible for Impaired Fibrinolysis in Obese Subjects and NIDDM Patients

McGill, J. B., Schneider, D. J., Arfken, C. L., Lucore, C. L., & Sobel, B. E. (1994) · Diabetes · doi:10.2337/diab.43.1.104 · Cited by 310 · see citing works

Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide.

Samad, F., Yamamoto, K., & Loskutoff, D. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118404 · Cited by 304 · see citing works

Elevated Expression of Transforming Growth Factor-β in Adipose Tissue from Obese Mice

Samad, F., Yamamoto, K., Pandey, M., & Loskutoff, D. J. (1997) · Molecular Medicine · doi:10.1007/bf03401666 · Cited by 303 · see citing works

Factor VII and Fibrinogen Levels as Risk Factors for Venous Thrombosis

Koster, T., Rosendaal, F. R., Reitsma, P. H., van der Velden, P. A., Briët, E., & Vandenbroucke, J. P. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1642511 · Cited by 294 · see citing works

Prognostic impact of urokinase, urokinase receptor, and type 1 plasminogen activator inhibitor in squamous and large cell lung cancer tissue.

Pedersen, H., Brünner, N., Francis, D., Østerlind, K., Rønne, E., Hansen, H. H., Danø, K., & Grøndahl-Hansen, J. (1994) · PubMed · Cited by 286 · see citing works

Effect of Activation and Inhibition of the Renin-Angiotensin System on Plasma PAI-1

Brown, N. J., Ağırbaşlı, M. A., Williams, G. H., Litchfield, W. R., & Vaughan, D. E. (1998) · Hypertension · doi:10.1161/01.hyp.32.6.965 · Cited by 269 · see citing works

Complete Deficiency of Plasminogen-Activator Inhibitor Type 1 Due to a Frame-Shift Mutation

Fay, W. P., Shapiro, A. D., Shih, J. L., Schleef, R. R., & Ginsburg, D. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212103272406 · Cited by 269 · see citing works

Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies.

Bini, A., Fenoglio, J. J., Mesa‐Tejada, R., Kudryk, B. J., & Kaplan, K. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.1.109 · Cited by 267 · see citing works

Type 1 plasminogen activator inhibitor

三室, 淳. (1990) · Medical Entomology and Zoology · Cited by 266 · see citing works

Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene

Erickson, L. A., Fici, G. J., Lund, J. E., Boyle, T. P., Polites, H. G., & Marotti, K. R. (1990) · Nature · doi:10.1038/346074a0 · Cited by 266 · see citing works

Effects of Ramipril on Plasma Fibrinolytic Balance in Patients With Acute Anterior Myocardial Infarction

Vaughan, D. E., Rouleau, J. L., Ridker, P. M., Arnold, J. M. O., Menapace, F. J., & Pfeffer, M. A. (1997) · Circulation · doi:10.1161/01.cir.96.2.442 · Cited by 264 · see citing works

Human aging: Changes in structure and function

Lakatta, E. G., Mitchell, J. H., Pomerance, A., & Rowe, G. G. (1987) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(87)80447-3 · Cited by 263 · see citing works

Hypercoagulability in centenarians: the paradox of successful aging

Mari, D., Mannucci, P. M., Coppola, R., Bottasso, B., Bauer, K. A., & ROSENBERG, R. D. (1995) · Blood · doi:10.1182/blood.v85.11.3144.bloodjournal85113144 · Cited by 257 · see citing works

Aging Increases Aortic MMP-2 Activity and Angiotensin II in Nonhuman Primates

Wang, M., Takagi, G., Asai, K., Resuello, R. G., Natividad, F. F., Vatner, D. E., Vatner, S. F., & Lakatta, E. G. (2003) · Hypertension · doi:10.1161/01.hyp.0000073843.56046.45 · Cited by 235 · see citing works

Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1

Samad, F., Uysal, K. T., Wiesbrock, S. M., Pandey, M., Hotamisligil, G. S., & Loskutoff, D. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6902 · Cited by 226 · see citing works

The cardiovascular risk factor plasminogen activator inhibitor type 1 is related to insulin resistance

van Loon, B. J. P., Kluft, C., Radder, J. K., Blankenstein, M. A., & Meinders, A. E. (1993) · Metabolism · doi:10.1016/0026-0495(93)90005-9 · Cited by 225 · see citing works

Aging and Thrombosis

Wilkerson, W. R., & Sane, D. C. (2002) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2002-36700 · Cited by 210 · see citing works

Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor.

Schleef, R. R., Higgins, D. L., Pillemer, E., & Levitt, L. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114076 · Cited by 209 · see citing works

The Natural Course of Atherosclerosis

Kiechl, S. J., & Willeit, J. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1491 · Cited by 209 · see citing works

Changes of Plasma Coagulation and Fibrinolysis in Response to Mental Stress

Jern, C., Eriksson, E., Tengborn, L., Risberg, B., Wadenvik, H., & Jern, S. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646899 · Cited by 206 · see citing works

Arterial and Venous Thrombosis Is Not Associated With the 4G/5G Polymorphism in the Promoter of the Plasminogen Activator Inhibitor Gene in a Large Cohort of US Men

Ridker, P. M., Hennekens, C. H., Lindpaintner, K., Stampfer, M. J., & Miletich, J. P. (1997) · Circulation · doi:10.1161/01.cir.95.1.59 · Cited by 202 · see citing works

Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer.

Nekarda, H., Schmitt, M., Ulm, K., Wenninger, A., Vogelsang, H., Becker, K., Roder, J. D., Fink, U., & Siewert, J. R. (1994) · PubMed · Cited by 201 · see citing works

Plasminogen Activator Inhibitor 1: A New Prognostic Marker in Septic Shock

Pralong, G., Calandra, T., Glausef, M.-P., Schellekens, J. F. P., Verhoef, J., Bachmann, F., & Kruithof, E. K. O. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646614 · Cited by 199 · see citing works

Aging-associated changes in indices of thrombin generation and protein C activation in humans. Normative Aging Study.

Bauer, K. A., Weiss, L. M., Sparrow, D., Vokonas, P., & ROSENBERG, R. D. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113238 · Cited by 198 · see citing works

Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.

Yamamoto, K., & Loskutoff, D. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118691 · Cited by 198 · see citing works

Evidence for a Causal Role of the Renin-Angiotensin System in Vascular Dysfunction Associated With Insulin Resistance

Shinozaki, K., Ayajiki, K., Nishio, Y., Sugaya, T., Kashiwagi, A., & Okamura, T. (2003) · Hypertension · doi:10.1161/01.hyp.0000111136.86976.26 · Cited by 197 · see citing works

Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-1 in Obese Mice

Samad, F., & Loskutoff, D. J. (1996) · Molecular Medicine · doi:10.1007/bf03401641 · Cited by 189 · see citing works

Obesity and the risk of heart failure

Kenchaiah, S. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00066-0 · Cited by 186 · see citing works

Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery

Eitzman, D. T., Westrick, R. J., Xu, Z., Tyson, J. A., & Ginsburg, D. (2000) · Blood · doi:10.1182/blood.v96.13.4212 · Cited by 182 · see citing works

Altered Regulation of Matrix Metalloproteinase-2 in Aortic Remodeling During Aging

Wang, M., & Lakatta, E. G. (2002) · Hypertension · doi:10.1161/01.hyp.0000014506.13322.66 · Cited by 174 · see citing works

Age-Dependent Spontaneous Coronary Arterial Thrombosis in Transgenic Mice That Express a Stable Form of Human Plasminogen Activator Inhibitor-1

Eren, M., Painter, C., Atkinson, J. B., Declerck, P. J., & Vaughan, D. E. (2002) · Circulation · doi:10.1161/01.cir.0000023186.60090.fb · Cited by 170 · see citing works

Identification and distribution of fibrinogen, fibrin and fibrin (ogen) degradation products in atherosclerosis

Bini, A. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · Cited by 169 · see citing works

Determinants of Plasminogen Activator Inhibitor 1 Activity in Treated NIDDM and Its Relation to a Polymorphism in the Plasminogen Activator Inhibitor 1 Gene

Panahloo, A., Mohamed‐Ali, V., Lane, A. M., Green, F. R., Humphries, S. E., & Yudkin, J. S. (1995) · Diabetes · doi:10.2337/diab.44.1.37 · Cited by 167 · see citing works

Metformin Decreases the High Plasminogen Activator Inhibition Capacity, Plasma Insulin and Triglyceride Levels in Non-Diabetic Obese Subjects

Vague, P., Juhan-Vague, I., Alessi, M., Badier, C., & Valadier, J. (1987) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1651126 · Cited by 164 · see citing works

Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals

Yamamoto, K., Takeshita, K., Shimokawa, T., Yi, H., Isobe, K., Loskutoff, D. J., & Saito, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022608799 · Cited by 163 · see citing works

Coagulation Factor VII and the Risk of Coronary Heart Disease in Healthy Men

Junker, R., Heinrich, J., Schulte, H., van de Loo, J., & Assmann, G. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1539 · Cited by 163 · see citing works

Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long-term Nitric Oxide Synthase Inhibition

Kaikita, K., Fogo, A. B., Ma, L., Schoenhard, J. A., Brown, N. J., & Vaughan, D. E. (2001) · Circulation · doi:10.1161/hc3301.092803 · Cited by 161 · see citing works

Acute Release of Plasminogen Activator Inhibitor-1 in ST-Segment Elevation Myocardial Infarction Predicts Mortality

Collet, J., Montalescot, G., Vicaut, É., Ankri, A., Walylo, F., Lesty, C., Choussat, R., Beygui, F., Borentain, M., Vignolles, N., et al. (2003) · Circulation · doi:10.1161/01.cir.0000083471.33820.3c · Cited by 158 · see citing works

Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide.

Fearns, C., Kravchenko, V. V., Ulevitch, R. J., & Loskutoff, D. J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.857 · Cited by 157 · see citing works

Plasminogen Activator Inhibitor-1 (PAI-1) Promoter Polymorphism and Coronary Artery Disease in Non-Insulin-Dependent Diabetes

Mansfield, M. W., Stickland, M. H., & Grant, P. J. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649875 · Cited by 151 · see citing works

Plasminogen Activator Inhibitor-1 Promoter 4G/5G Genotype and Plasma Levels in Relation to a History of Myocardial Infarction in Patients Characterized by Coronary Angiography

Ossei‐Gerning, N., Mansfield, M. W., Stickland, M. H., Wilson, I., & Grant, P. J. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.33 · Cited by 142 · see citing works

Effect of plasminogen activator inhibitor–1 in diabetes mellitus and cardiovascular disease

Lyon, C. J., & Hsueh, W. A. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.08.014 · Cited by 131 · see citing works

Increase of Plasminogen Activator Inhibitor Levels Predicts Outcome of Leukocytopenic Patients with Sepsis

Mesters, R. M., Flörke, N., Ostermann, H., & Kienast, J. (1996) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1650392 · Cited by 125 · see citing works

Angiotensin II type 1 receptor−153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects

Lajemi, M., Labat, C., Gautier, S., Lacolley, P. J., Safar, M. E., Asmar, R. G., Cambien, F., & Bénétos, A. (2001) · Journal of Hypertension · doi:10.1097/00004872-200103000-00008 · Cited by 125 · see citing works

Plasminogen activator inhibitor‐1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin

Deng, G. G., Curriden, S. A., Hu, G., Czekay, R., & Loskutoff, D. J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1133 · Cited by 124 · see citing works

Increased Expression of Plasminogen Activator Inhibitor-1 in Cardiomyocytes Contributes to Cardiac Fibrosis after Myocardial Infarction

Takeshita, K., Hayashi, M., Iino, S., Kondo, T., Inden, Y., Iwase, M., Kojima, T., Hirai, M., Ito, M., Loskutoff, D. J., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63135-5 · Cited by 122 · see citing works

Type 1 plasminogen activator inhibitor

Mimuro, J. (1990) · Japanese Journal of Thrombosis and Hemostasis · doi:10.2491/jjsth.1.17 · Cited by 116 · see citing works

Enhanced in vivo platelet “release reaction” in old healthy individuals

Zahavi, J., Jones, N. A. G., Leyton, J., Dubiel, M., & Kakkar, V. V. (1980) · Thrombosis Research · doi:10.1016/0049-3848(80)90067-5 · Cited by 115 · see citing works

Factors influencing the accumulation in fibrous plaques of lipid derived from low density lipoprotein

Smith, E. B., Keen, G. A., & GRANT, A. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90087-y · Cited by 115 · see citing works

Relationship between age and plasma t-PA, PA-inhibitor, and PA activity

Hashimoto, Y., Kobayashi, A., Yamazaki, N., Sugawara, Y., Takada, Y., & Takada, A. (1987) · Thrombosis Research · doi:10.1016/0049-3848(87)90264-7 · Cited by 111 · see citing works

Plasminogen Activator Inhibitor-1 Expression in Human Liver and Healthy or Atherosclerotic Vessel Walls

Chomiki, N., Henry, M., Alessi, M., Anfosso, F. J., & Juhan-Vague, I. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648809 · Cited by 108 · see citing works

Association of Chronic Stress With Plasminogen Activator Inhibitor–1 in Healthy Middle-aged Men

Räikkönen, K., Lassila, R., Keltikangas‐Järvinen, L., & Hautanen, A. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.3.363 · Cited by 96 · see citing works

Activation of neurohumoral systems following acute myocardial infarction

Rouleau, J. L., Moyé, L. A., de Champlain, J., Klein, M. D., Bichet, D. G., Packer, M., Sussex, B. A., Arnold, J. M. O., Sestier, F., Parker, J. O., et al. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90264-l · Cited by 96 · see citing works

Age-related changes in the hemostatic system

Abbate, R., Prisco, D., Rostagno, C., Boddi, M., & Gensini, G. F. (1993) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02592271 · Cited by 95 · see citing works

Cardiac Senescence Is Associated with Enhanced Expression of Angiotensin II Receptor Subtypes1

Heymes, C., Silvestre, J., Llorens‐Cortés, C., Marotte, F., Chevalier, B., Levy, B. I., Bernard Swynghedauw, A., & Samuel, J. (1998) · Endocrinology · doi:10.1210/endo.139.5.6023 · Cited by 93 · see citing works

Thrombin-Activatable Fibrinolysis Inhibitor Antigen Levels and Cardiovascular Risk Factors

Juhan-Vague, I., Renucci, J. F., Grimaux, M., Morange, P., Gouvernet, J., Gourmelin, Y., & Alessi, M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2156 · Cited by 92 · see citing works

Factors responsible for impaired fibrinolysis in obese subjects and NIDDM patients

McGill, J. B., Schneider, D. J., Arfken, C. L., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.1.104 · Cited by 89 · see citing works

Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, "Klotho" Mouse

Takeshita, K., Yamamoto, K., Ito, M., Kondo, T., Matsushita, T., Hirai, M., Kojima, T., Nishimura, M., Nabeshima, Y., Loskutoff, D. J., et al. (2002) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2002-36699 · Cited by 86 · see citing works

Oxidative Stress Activates the Plasminogen Activator Inhibitor Type 1 (PAI-1) Promoter through an AP-1 Response Element and Cooperates with Insulin for Additive Effects on PAI-1 Transcription

Vulin, A. I., & Stanley, F. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403184200 · Cited by 86 · see citing works

Obesity, fat distribution and cardiovascular disease.

Larsson, B. (1991) · PubMed · Cited by 85 · see citing works

Platelet activity and phosphoinositide turnover increase with advancing age

Bastyr, E. J., Kadrofske, M. M., & Vinik, A. I. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90525-i · Cited by 83 · see citing works

Aging Accelerates Endotoxin-Induced Thrombosis

Yamamoto, K., Shimokawa, T., Yi, H., Isobe, K., Kojima, T., Loskutoff, D. J., & Saito, H. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64457-4 · Cited by 76 · see citing works

The Distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years results from the cardiovascular health study

Tracy, R. P., Bovill, E. G., Fried, L. P., HEISS, G. M., Lee, M. H., Polak, J. F., Psaty, B. M., & Savage, P. J. (1992) · Annals of Epidemiology · doi:10.1016/1047-2797(92)90100-5 · Cited by 76 · see citing works

Thrombin‐activatable fibrinolysis inhibitor in young patients with myocardial infarction and its relationship with the fibrinolytic function and the protein C system

Zorio, E., Castelló, R., Falcó, C., España, F., Osa, A., Bonet, L. A., Aznar, J., & Estellés, A. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04549.x · Cited by 75 · see citing works

In vivo modulation of coagulation and fibrinolysis by recombinant glycosylated human interleukin-6 in baboons.

Mestries, J. C., Kruithof, E. K. O., Gascon, M.-P., Hérodin, F., Agay, D., & Ythier, A. (1994) · PubMed · Cited by 73 · see citing works

Correlates of Thrombin Markers in an Elderly Cohort Free of Clinical Cardiovascular Disease

Cushman, M., Psaty, B. M., Macy, E., Bovill, E. G., Cornell, E. S., Kuller, L. H., & Tracy, R. P. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.9.1163 · Cited by 71 · see citing works

Aging, Carotid Artery Distensibility, and the Ser422Gly Elastin Gene Polymorphism in Humans

Hanon, O., Luong, V., Mourad, J., Bortolotto, L. A., Jeunemaı̂tre, X., & Girerd, X. J. (2001) · Hypertension · doi:10.1161/hy1101.096802 · Cited by 69 · see citing works

Genetic Mechanisms of Age Regulation of Human Blood Coagulation Factor IX

Kurachi, S., Deyashiki, Y., Takeshita, J., & Kurachi, K. (1999) · Science · doi:10.1126/science.285.5428.739 · Cited by 68 · see citing works

A pathological role of increased expression of plasminogen activator inhibitor-1 in human or animal disorders.

Yamamoto (1998) · International Journal of Hematology · doi:10.1016/s0925-5710(98)00094-2 · Cited by 67 · see citing works

The Tissue Factor and Plasminogen Activator Inhibitor Type-1 Response in Pediatric Sepsis-induced Multiple Organ Failure

Green, J., Doughty, L., Kaplan, S. S., Sasser, H. C., & Carcillo, J. A. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1612976 · Cited by 66 · see citing works

Stressful events as a trigger of sudden death: a study of 43 medico-legal autopsy cases

Lecomte, D., Fornés, P., & Nicolas, G. (1996) · Forensic Science International · doi:10.1016/0379-0738(95)01873-5 · Cited by 65 · see citing works

Insulin Continues to Induce Plasminogen Activator Inhibitor 1 Gene Expression in Insulin-Resistant Mice and Adipocytes

Samad, F., Pandey, M., Bell, P. A., & Loskutoff, D. J. (2000) · Molecular Medicine · doi:10.1007/bf03402048 · Cited by 64 · see citing works

Natural anticoagulants, aging, and thromboembolism

Sagripanti, A., & Carpi, A. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00047-3 · Cited by 64 · see citing works

Correlates of Antithrombin, Protein C, Protein S, and TFPI in a Healthy Elderly Cohort

Sakkinen, P. A., Cushman, M., Psaty, B. M., Kuller, L. H., Bajaj, S. P., Sabharwal, A., Boineau, R., Macy, E., & Tracy, R. P. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615152 · Cited by 64 · see citing works

Hyperglycemia induces PAI-1 gene expression in adipose tissue by activation of the hexosamine biosynthetic pathway

Gabriely, I., Yang, X. M., Cases, J. A., Xiao, H., Rossetti, L., & Barzilai, N. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00574-3 · Cited by 62 · see citing works

Plasminogen activator inhibitor-1 messenger RNA expression is induced in rat hepatocytes in vivo by dexamethasone

Konkle, B. A., Schuster, S. J., Kelly, M., Harjes, K., Hassett, D., Bohrer, M., & Tavassoli, M. (1992) · Blood · doi:10.1182/blood.v79.10.2636.2636 · Cited by 61 · see citing works

Determinants of plasminogen activator inhibitor 1 activity in treated NIDDM and its relation to a polymorphism in the plasminogen activator inhibitor 1 gene

Panahloo, A., Mohamed‐Ali, LANE, A., et al. (1995) · Diabetes · doi:10.2337/diabetes.44.1.37 · Cited by 59 · see citing works

Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones

Leugers, A., Lohrmann, J., Ernst, S., Sobel, B. E., Bode, C., Nordt, T. K., & Zirlik, A. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-06-0384 · Cited by 58 · see citing works

Substrate-bound fibrinogen, fibrin and other cell attachment-promoting proteins as a scaffold for cultured vascular smooth muscle cells

Naito, M., FUNAKI, C., Hayashi, T., Yamada, K., Asai, K., Yoshimine, N., & Kuzuya, F. (1992) · Atherosclerosis · doi:10.1016/0021-9150(92)90069-s · Cited by 57 · see citing works

Elevated Plasminogen Activator Inhibitor (PAI), a Cause of Thrombophilia? – A Study in 203 Patients with Familial or Sporadic Venous Thrombophilia

Engesser, L., Brommer, E. J. P., Kluft, C., & Briët, E. (1989) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1646881 · Cited by 52 · see citing works

Influence of Metoprolol Treatment on Sympatho-Adrenal Activation of Fibrinolysis

Larsson, P. T., Wiman, B., Olsson, G., Angelin, B., & Hjemdahl, P. (1990) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1645070 · Cited by 48 · see citing works

Plasminogen activator inhibitor-1 messenger RNA expression is induced in rat hepatocytes in vivo by dexamethasone

Konkle, B., Schuster, S. J., Kelly, M., et al. (1992) · Blood · doi:10.1182/blood.v79.10.2636.bloodjournal79102636 · Cited by 48 · see citing works

Thrombosis and cardiovascular risk in the elderly.

Tracy, R., & BOVILL, E. G. (1992) · PubMed · Cited by 46 · see citing works

Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse

Yamamoto, K., Shimokawa, T., Yi, H., Isobe, K., Kojima, T., Loskutoff, D. J., & Saito, H. (2002) · Blood · doi:10.1182/blood-2002-03-0945 · Cited by 37 · see citing works

Sympathetic nervous system activity and α-adrenergic responsiveness in older hypertensive humans

Supiano, M. A., Hogikyan, R. V., Sidani, M. A., Gałecki, A. T., & Krueger, J. L. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.3.e519 · Cited by 37 · see citing works

Cardiac Senescence Is Associated with Enhanced Expression of Angiotensin II Receptor Subtypes

Heymes, C. (1998) · Endocrinology · doi:10.1210/en.139.5.2579 · Cited by 26 · see citing works

Age related changes of platelet prostacyclin receptors in humans

Modesti, P. A., Fortini, A., Abbate, R., & Gensini, G. F. (1985) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1985.tb00169.x · Cited by 25 · see citing works

Genetic Mechanisms of Age Regulation of Protein C and Blood Coagulation

Zhang, K., Kurachi, S., & Kurachi, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109524200 · Cited by 25 · see citing works

Augmented Age-associated Innate Immune Responses Contribute to Negative Inotropic and Lusitropic Effects of Lipopolysaccharide and Interferon γ

Rosas, G. O., Zieman, S. J., Donabedian, M., Vandegaer, K. M., & Hare, J. M. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1448 · Cited by 23 · see citing works

266 Plasminogen activator inhibitor-1: A new prognostic marker in septic shock

Pralong, G., Calandra, T., Glauser, M. P., Bachmann, F., & Kruithof, E. K. O. (1988) · Fibrinolysis and Proteolysis · doi:10.1016/0268-9499(88)90613-3 · Cited by 18 · see citing works

Association of functional thrombin‐activatable fibrinolysis inhibitor (TAFI) with conventional cardiovascular risk factors and its correlation with other hemostatic factors in a Spanish population

Santamaría, A., Borrell, M., Oliver, A., Ortín, R., Forner, R., Coll, I., Mateo, J., Souto, J. C., & Fontcuberta, J. (2004) · American Journal of Hematology · doi:10.1002/ajh.20108 · Cited by 17 · see citing works

On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines

Emeis, J. J., Brouwer, A., Barelds, R. J., Horan, M. A., Durham, S. R., & Kooistra, T. (1992) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648525 · Cited by 16 · see citing works

Elevated Plasminogen Activator Inhibitor Levels Found in Patients with Malignant Conditions

Newland, J. R., & Haire, W. D. (1991) · American Journal of Clinical Pathology · doi:10.1093/ajcp/96.5.602 · Cited by 14 · see citing works

Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery

Eitzman, D. T., Westrick, R. J., Xu, Z., et al. (2000) · Blood · doi:10.1182/blood.v96.13.4212.h8004212_4212_4215 · Cited by 14 · see citing works

Increased susceptibility of aged rats to haemorrhage and intravascular hypercoagulation following endotoxin administered in a generalized Shwartzman regime

Carthew, P., Dorman, B. M., & Edwards, R. (1991) · Journal of Comparative Pathology · doi:10.1016/s0021-9975(08)80200-9 · Cited by 8 · see citing works

The fibrinolytic system in aged rats, and its reactivity to endotoxin and cytokines

Emeis, J. J., Brouwer, A., Horan, M. A., Durham, S. K., & Kooistra, T. (1992) · Fibrinolysis and Proteolysis · doi:10.1016/0268-9499(92)90028-g · Cited by 5 · see citing works

[On measuring instability in demography].

Pirozhkov, S. I., & Gl, S. (1991) · PubMed · Cited by 2 · see citing works

Postmortem examination of COVID‐19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction

Menter, T., Haslbauer, J. D., Nienhold, R., Savic, S., Hopfer, H., Deigendesch, N., Frank, S., Turek, D., Willi, N., Pargger, H., et al. (2020) · Histopathology · doi:10.1111/his.14134 · Cited by 1,207 · see citing works

Determinants and Time Course of the Postthrombotic Syndrome after Acute Deep Venous Thrombosis

Kahn, S. R., Shrier, I., Julian, J. A., Ducruet, T., Arsenault, L., Miron, M. ‐., Roussin, A., Desmarais, S., Joyal, F., Kassis, J., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-10-200811180-00004 · Cited by 850 · see citing works

Aging and vascular endothelial function in humans

Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works

Circadian misalignment increases cardiovascular disease risk factors in humans

Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516953113 · Cited by 691 · see citing works

REVIEW: Plasminogen Activator Inhibitor‐1 (PAI‐1): A Key Factor Linking Fibrinolysis and Age‐Related Subclinical and Clinical Conditions

Cesari, M., Pahor, M., & Incalzi, R. A. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00171.x · Cited by 451 · see citing works

An aberrant STAT pathway is central to COVID-19

Matsuyama, T., Kubli, S. P., Yoshinaga, S. K., Pfeffer, K., & Mak, T. W. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-00633-7 · Cited by 292 · see citing works

Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow’s triad

Ahmed, S., Zimba, O., & Gasparyan, A. Y. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05275-1 · Cited by 251 · see citing works

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237 · see citing works

Aging, Cellular Senescence, and Alzheimer’s Disease

Liu, R.-M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041989 · Cited by 267 · see citing works

Plasminogen Activator Inhibitor Type‐1 as a Regulator of Fibrosis

Rabieian, R., Boshtam, M., Zareei, M., Kouhpayeh, S., Masoudifar, A., & Mirzaei, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26146 · Cited by 159 · see citing works

Hypercoagulability after trauma: Hemostatic changes and relationship to venous thromboembolism

Selby, R., Geerts, W., Ofosu, F. A., Craven, S. J., Dewar, L., Phillips, A., & Szalai, J. P. (2008) · Thrombosis Research · doi:10.1016/j.thromres.2008.10.002 · Cited by 151 · see citing works

Hemostasis and aging

Franchini, M. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.06.004 · Cited by 145 · see citing works

Hemostasis factors and aging

Mari, D., Coppola, R., & Provenzano, R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.014 · Cited by 147 · see citing works

Aging Hemostasis: Changes to Laboratory Markers of Hemostasis As We Age—A Narrative Review

Franchini, M., Lippi, G., & Favaloro, E. J. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1384631 · Cited by 145 · see citing works

Oxidative Stress in Aging-Matters of the Heart and Mind

Venkataraman, K., Khurana, S., & Tai, T. C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917897 · Cited by 143 · see citing works

Plasminogen Activator Inhibitor-1 Antagonist TM5441 Attenuates N ω -Nitro- l -Arginine Methyl Ester–Induced Hypertension and Vascular Senescence

Boe, A. E., Eren, M., Murphy, S. B., Kamide, C., Ichimura, A., Terry, D. B., McAnally, D., Smith, L. H., Miyata, T., & Vaughan, D. E. (2013) · Circulation · doi:10.1161/circulationaha.113.003192 · Cited by 134 · see citing works

The Plasminogen–Activator Plasmin System in Physiological and Pathophysiological Angiogenesis

Ismail, A. A., Shaker, B. T., & Bajou, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010337 · Cited by 134 · see citing works

Sustained prothrombotic changes in COVID-19 patients 4 months after hospital discharge

von Meijenfeldt, F. A., Havervall, S., Adelmeijer, J., Lundström, A., Magnusson, M., Mackman, N., Thålin, C., & Lisman, T. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003968 · Cited by 131 · see citing works

A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

Morrow, G. B., Whyte, C. S., & Mutch, N. J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.653655 · Cited by 121 · see citing works

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly

Violi, F., Loffredo, L., Carnevale, R., Pignatelli, P., & Pastori, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6963 · Cited by 121 · see citing works

Adipose Tissue‐Derived Plasminogen Activator Inhibitor‐1 Function and Regulation

Kaji, H. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160004 · Cited by 106 · see citing works

Cell non-autonomous regulation of health and longevity

Miller, H. A., Kitto, E. S., Pletcher, S. D., & Leiser, S. F. (2020) · eLife · doi:10.7554/elife.62659 · Cited by 97 · see citing works

COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury

Nicosia, R. F., Ligresti, G., Caporarello, N., Akilesh, S., & Ribatti, D. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.05.007 · Cited by 102 · see citing works

Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease

Liu, R., Groen, T. V., Katre, A. K., Cao, D., Kadisha, I., Ballinger, C. A., Wang, L., Carroll, S. L., & Li, L. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.06.003 · Cited by 95 · see citing works

Stress Augments Insulin Resistance and Prothrombotic State

Uchida, Y., Takeshita, K., Yamamoto, K., Kikuchi, R., Nakayama, T., Nomura, M., Cheng, X. W., Egashira, K., Matsushita, T., Nakamura, H., et al. (2012) · Diabetes · doi:10.2337/db11-0828 · Cited by 90 · see citing works

Metabolic, inflammatory, endothelial and haemostatic markers in a group of Italian obese children and adolescents

Giordano, P., Vecchio, G., Cecinati, V., Delvecchio, M., Altomare, M., Palma, F. D., Mattia, D. D., Cavallo, L., & Faienza, M. F. (2011) · European Journal of Pediatrics · doi:10.1007/s00431-010-1356-7 · Cited by 90 · see citing works

Predictors of the post‐thrombotic syndrome with non‐invasive venous examinations in patients 6 weeks after a first episode of deep vein thrombosis

Tick, L. W., Doggen, C. J. M., Rosendaal, F. R., Faber, W. R., Bousema, M. T., Mackaay, A. J. C., van Balen, P., & Kramer, M. H. H. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.04065.x · Cited by 88 · see citing works

PAI-1, the Plasminogen System, and Skeletal Muscle

Rahman, F. A., & Krause, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197066 · Cited by 87 · see citing works

Angiotensin receptor blocker irbesartan reduces stress-induced intestinal inflammation via AT1a signaling and ACE2-dependent mechanism in mice

Yisireyili, M., Uchida, Y., Yamamoto, K., Nakayama, T., Cheng, X. W., Matsushita, T., Nakamura, S., Murohara, T., & Takeshita, K. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.010 · Cited by 85 · see citing works

The aging venous system: from varicosities to vascular cognitive impairment

Molnár, A. Á., Nádasy, G. L., Dörnyei, G., Patai, B. B., DelFavero, J., Fülöp, G., Kirkpatrick, A. C., Ungvari, Z. I., & Merkely, B. P. (2021) · GeroScience · doi:10.1007/s11357-021-00475-2 · Cited by 73 · see citing works

The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor

Weigel, R., Schilling, L., & Krauss, J. K. (2022) · GeroScience · doi:10.1007/s11357-022-00570-y · Cited by 70 · see citing works

Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass

Pretorius, M., Donahue, B. S., Yu, C., Greelish, J. P., Roden, D. M., & Brown, N. J. (2007) · Circulation · doi:10.1161/circulationaha.106.677906 · Cited by 69 · see citing works

Electronic cigarette exposure causes vascular endothelial dysfunction due to NADPH oxidase activation and eNOS uncoupling

El‐Mahdy, M. A., Ewees, M. G., Eid, M. S., Mahgoup, E. M., Khaleel, S. A., & Zweier, J. L. (2022) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00460.2021 · Cited by 68 · see citing works

Intra-Arterial Recanalization Techniques for Patients 80 Years or Older with Acute Ischemic Stroke: Pooled Analysis from 4 Prospective Studies

Qureshi, A. I., Suri, M. F., Georgiadis, A., Vazquez, G., & Janjua, N. A. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1503 · Cited by 60 · see citing works

Plasminogen activator inhibitor-1 is an aggregate response factor with pleiotropic effects on cell signaling in vascular disease and the tumor microenvironment

Gramling, M., & Church, F. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2009.11.034 · Cited by 58 · see citing works

Post-challenge hyperglycaemia, nitric oxide production and endothelial dysfunction: the putative role of asymmetric dimethylarginine (ADMA).

Siervo, M., Corander, M., Stranges, S., & Bluck, L. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.10.003 · Cited by 55 · see citing works

Role of oxidative stress on platelet hyperreactivity during aging

Eduardo Fuentes, Q., & Palomo, I. F. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.02.026 · Cited by 55 · see citing works

Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle

Rahman, F. A., Angus, S. A., Stokes, K., Karpowicz, P. A., & Krause, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134575 · Cited by 55 · see citing works

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

Matsuyama, T., Yoshinaga, S. K., Shibue, K., & Mak, T. W. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00892-y · Cited by 52 · see citing works

Silibinin as potential tool against SARS‐Cov ‐2: In silico spike receptor‐binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects

Speciale, A., Muscarà, C., Molonia, M. S., Cimino, F., Saija, A., & Giofrè, S. V. (2021) · Phytotherapy Research · doi:10.1002/ptr.7107 · Cited by 52 · see citing works

Circulating Inflammatory Markers and Hemostatic Factors in Age-Related Maculopathy: A Population-Based Case–Control Study

Wu, K. H. C., Tan, A. G., Rochtchina, E., Favaloro, E. J., Williams, A., Mitchell, P., & Wang, J. J. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0223 · Cited by 52 · see citing works

The Central Role of Fibrinolytic Response in COVID-19—A Hematologist’s Perspective

Kwaan, H. C., & Lindholm, P. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031283 · Cited by 50 · see citing works

Cerebral venous thrombosis in COVID-19

Ghosh, R., Roy, D., Mandal, A., Pal, S. K., Swaika, B. C., Naga, D., Pandit, A., Ray, B. K., & Benito‐León, J. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.04.026 · Cited by 51 · see citing works

Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin receptor agonists

Garabet, L., Henriksson, C. E., Lozano, M. L., Ghanima, W., Bussel, J. B., Brodin, E. E., Fernández-Pérez, M. P., Martı́nez, C., Gónzález‐Conejero, R., Mowinckel, M., et al. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.11.031 · Cited by 49 · see citing works

The Aging Heart: A Molecular and Clinical Challenge

Lazzeroni, D., Villatore, A., Souryal, G., Pili, G., & Peretto, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416033 · Cited by 51 · see citing works

Gene expression profile of mouse white adipose tissue during inflammatory stress: age‐dependent upregulation of major procoagulant factors

Starr, M. E., Hu, Y., Stromberg, A. J., Carmical, J. R., Wood, T. G., Evers, B. M., & Saitō, H. (2012) · Aging Cell · doi:10.1111/acel.12040 · Cited by 46 · see citing works

The Molecular Mechanisms of Intestinal Inflammation and Fibrosis in Crohn’s Disease

Hayashi, Y., & Nakase, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.845078 · Cited by 46 · see citing works

Aging is associated with impaired thrombus resolution in a mouse model of stasis induced thrombosis

McDonald, A. P., Meier, T. R., Hawley, A. E., Thibert, J. N., Farris, D. M., Wrobleski, S. K., Henke, P. K., Wakefield, T. W., & Myers, D. D. (2009) · Thrombosis Research · doi:10.1016/j.thromres.2009.06.005 · Cited by 44 · see citing works

Post-thrombotic syndrome 3 years after deep venous thrombosis in the Thrombosis and Pulmonary Embolism in Out-Patients (TULIPA) PLUS Registry

Hach-Wunderle, V., Bauersachs, R. M., Gerlach, H.-E., Eberle, S., Schellong, S., Riess, H. B., Carnarius, H., & Rabe, E. (2013) · Journal of Vascular Surgery Venous and Lymphatic Disorders · doi:10.1016/j.jvsv.2012.07.003 · Cited by 42 · see citing works

Platelets in aging and cancer—“double-edged sword”

Faria, A. V. S., Andrade, S. S., Peppelenbosch, M. P., Ferreira-Halder, C. V., & Fuhler, G. M. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09926-2 · Cited by 38 · see citing works

Comparison of Plasminogen Activator Inhibitor-1, Tissue Type Plasminogen Activator Antigen, Fibrinogen, and D-Dimer Levels in Various Age Decades in Patients With Type 2 Diabetes Mellitus and Stable Coronary Artery Disease (from the BARI 2D Trial)

McBane, R. D., Hardison, R. M., & Sobel, B. E. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.08.643 · Cited by 40 · see citing works

Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase

Garcia, V. G., Park, E. J., Siragusa, M., Fröhlich, F., Haque, M. M., Pascale, J. V., Heberlein, K. R., Isakson, B. E., Stuehr, D. J., & Sessa, W. C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918761117 · Cited by 39 · see citing works

DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

Matías‐García, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., Gao, X. Y., Nano, J., Bostom, A. G., Colicino, E., et al. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01082-w · Cited by 37 · see citing works

Aging hearts and vessels: Masters of adaptation and survival

Pepe, S., & Lakatta, E. G. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.03.004 · Cited by 39 · see citing works

The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome

Corgosinho, F. C., de Piano, A., Sanches, P. D. L., Campos, R. M. D. S., Silva, P. L., Carnier, J., Oyama, L. M., Tock, L., Tufik, S., de Mello, M. T., et al. (2011) · Inflammation · doi:10.1007/s10753-011-9397-2 · Cited by 38 · see citing works

Small Airways Disease, Biomarkers and COPD: Where are We?

Chukowry, P., Spittle, D. A., & Turner, A. M. (2021) · International Journal of COPD · doi:10.2147/copd.s280157 · Cited by 38 · see citing works

PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea?

Badran, M., & Gozal, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105516 · Cited by 36 · see citing works

Primary and secondary haemostasis changes related to aging

Sepúlveda, C., Palomo, I. F., & Eduardo Fuentes, Q. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.08.006 · Cited by 36 · see citing works

Fibrinolysis for Intermediate-Risk Pulmonary Embolism

Meyer, G., Vicaut, É., & Konstantinides, S. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1406283 · Cited by 36 · see citing works

Docosahexaenoic acid prevented tumor necrosis factor alpha-induced endothelial dysfunction and senescence

Yamagata, K., Suzuki, S., & Tagami, M. (2015) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.10.006 · Cited by 35 · see citing works

Hemostasis and Thrombosis in the Oldest Old

Hoffman, R., Monréal, M., & Tzoran, I. (2018) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0038-1657779 · Cited by 35 · see citing works

Endothelial PPARγ Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK

Uddin, M. S., Kabir, M. T., Jakaria, M., Mamun, A. A., Niaz, K., Amran, M. S., Barreto, G. E., & Ashraf, G. M. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00047-5 · Cited by 34 · see citing works

The plasminogen activating system in the pathogenesis of Alzheimer’s disease

Yepes, M. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.308076 · Cited by 33 · see citing works

Management of Venous Thromboembolism in the Elderly

Spyropoulos, A. C., & Merli, G. J. (2006) · Drugs & Aging · doi:10.2165/00002512-200623080-00003 · Cited by 34 · see citing works

Platelet oxidative stress as a novel target of cardiovascular risk in frail older people

Fuentes, F., Palomo, I. F., & Eduardo Fuentes, Q. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.07.003 · Cited by 35 · see citing works

Plasma markers of inflammation and hemostatic and endothelial activity in naturally overweight and obese dogs

Rafaj, R. B., Kuleš, J., Marinculić, A., Tvarijonaviciute, A., Cerón, J. M. C., Mihaljević, Ž., Tumpa, A., & Mrljak, V. (2016) · BMC Veterinary Research · doi:10.1186/s12917-016-0929-8 · Cited by 33 · see citing works

The beneficial effects of aerobic and concurrent training on metabolic profile and body composition after detraining: a 1-year follow-up in postmenopausal women

Rossi, F. E., Diniz, T. A., Neves, L. M., Fortaleza, A. C. D. S., Gerosa-Neto, J., Inoue, D. S., Buonani, C., Cholewa, J. M., Lira, F. S., & Júnior, I. F. F. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.263 · Cited by 33 · see citing works

Plasminogen activator inhibitor-1 is elevated in patients with COPD independent of metabolic and cardiovascular function

Waschki, B., Watz, H., Holz, O., MAGNUSSEN, H., Olejnicka, B. T., Welte, T., Rabe, K. F., & Janciauskiene, S. M. (2017) · International Journal of COPD · doi:10.2147/copd.s128689 · Cited by 33 · see citing works

Ablation of Angiotensin IV Receptor Attenuates Hypofibrinolysis via PAI-1 Downregulation and Reduces Occlusive Arterial Thrombosis

Numaguchi, Y., Ishii, M., Kubota, R., Morita, Y., Yamamoto, K., Matsushita, T., Okumura, K., & Murohara, T. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.195057 · Cited by 31 · see citing works

Thrombosis and Aging: Fibrin Clot Properties and Oxidative Stress

Konieczyńska, M., Natorska, J., & Undas, A. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0365 · Cited by 31 · see citing works

Fibrinolysis in Patients with Liver Disease

von Meijenfeldt, F. A., & Lisman, T. (2021) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0040-1718924 · Cited by 30 · see citing works

Dysregulation of Pulmonary Responses in Severe COVID-19

Wu, D., & Yang, X. O. (2021) · Viruses · doi:10.3390/v13060957 · Cited by 30 · see citing works

PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells

Rana, T., Jiang, C., Banerjee, S., Yi, N., Zmijewski, J. W., Liu, G., & Liu, R.-M. (2023) · Cells · doi:10.3390/cells12152008 · Cited by 29 · see citing works

TP53/miR-34a-associated signaling targets SERPINE1 expression in human pancreatic cancer

Akula, S. M., Ruvolo, P. P., & McCubrey, J. A. (2020) · Aging · doi:10.18632/aging.102776 · Cited by 29 · see citing works

Endothelial and Metabolic Function Interactions in Overweight/Obese Children:

Ciccone, M. M., Faienza, M. F., Altomare, M., Nacci, C., Montagnani, M., Valente, F., Cortese, F., Gesualdo, M., Zito, A., Mancarella, R., et al. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.31740 · Cited by 29 · see citing works

Transforming growth factor-beta 1 levels in women with prior history of gestational diabetes mellitus

Yener, S., Demir, T., Akıncı, B., Bayraktar, F., Kebapçılar, L., Özcan, M. A., Biberoǧlu, S., & Yeşil, S. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.08.014 · Cited by 29 · see citing works

Lifelong dietary omega-3 fatty acid suppresses thrombotic potential through gut microbiota alteration in aged mice

Saravi, S. S. S., Bonetti, N. R., Pugin, B., Constancias, F., Pasterk, L., Gobbato, S., Akhmedov, A. T., Liberale, L., Lüscher, T. F., Camici, G. G., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102897 · Cited by 28 · see citing works

CTSS Modulates Stress-Related Carotid Artery Thrombosis in a Mouse FeCl 3 Model

Xu, S., Piao, L., Wan, Y., Huang, Z., Meng, X., Inoue, A., Wang, H., Yue, X., Jin, X., Shi, G., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318455 · Cited by 28 · see citing works

The Impact of an Aging Population on the Diagnosis of Pulmonary Embolism: Comparison of Young and Elderly Patients

Castelli, R., Bergamaschini, L. C., Sailis, P., Pantaleo, G., & Porro, F. (2007) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029607308860 · Cited by 29 · see citing works

Biomarkers associated with coronary high-risk plaques

Nakajima, A., Libby, P., Mitomo, S., Yuki, H., Araki, M., Seegers, L. M., McNulty, I. A., Lee, H., みどり, 石., Kobayashi, K., et al. (2022) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-022-02709-2 · Cited by 27 · see citing works

Getting old through the blood: circulating molecules in aging and senescence of cardiovascular regenerative cells

Angelini, F., Pagano, F., Bordin, A., Picchio, V., De Falco, E., & Chimenti, I. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00062 · Cited by 25 · see citing works

Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis

Jiang, C., Liu, G., Cai, L., Deshane, J. S., Antony, V. B., Thannickal, V. J., & Liu, R.-M. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.04.003 · Cited by 25 · see citing works

Plasma‐Derived Nanoclusters for Site‐Specific Multimodality Photo/Magnetic Thrombus Theranostics

Liu, C., Liu, M.-C. J., Jheng, P., Yu, J., Fan, Y., Liang, J., Hsiao, Y., Chiang, C., Bolouki, N., Lee, J., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301504 · Cited by 25 · see citing works

The impact of frailty on coagulation and responses to warfarin in acute older hospitalised patients with atrial fibrillation: a pilot study

Nguyen, T. N., Morel‐Kopp, M., Pepperell, D., Cumming, R. G., Hilmer, S. N., & Wård, C. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0733-8 · Cited by 25 · see citing works

Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model

Jin, X., Jin, C., Nakamura, K., Jin, T., Xin, M., Wan, Y., Yue, X., Jin, S., Wang, H., Inoue, A., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002418 · Cited by 25 · see citing works

Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells

Song, L., Tada, H., Nishioka, T., Nemoto, E., Imamura, T., Potempa, J., Li, C., Matsushita, K., & Sugawara, S. (2021) · Journal of Innate Immunity · doi:10.1159/000519737 · Cited by 24 · see citing works

Postmortem pathological changes in extrapulmonary organs in SARS-CoV-2 rt-PCR–positive cases: a single-center experience

Buğra, A., Daş, T., Arslan, M. N., Ziyade, N., & Büyük, Y. (2021) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-021-02638-8 · Cited by 23 · see citing works

Aging, Plasminogen Activator Inhibitor 1, Brain Cell Senescence, and Alzheimer's Disease.

Jiang, C., Rana, T., Jin, L., Farr, S. A., Morley, J. E., Qin, H., Liu, G., & Liu, R.-M. (2023) · PubMed Central · doi:10.14336/ad.2022.1220 · Cited by 23 · see citing works

A serine protease secreted from Bacillus subtilis cleaves human plasma transthyretin to generate an amyloidogenic fragment

Peterle, D., Pontarollo, G., Spada, S., Brun, P., Palazzi, L., Sokolov, A. V., Spolaore, B., de Laureto, P. P., Vasilyev, V., Castagliuolo, I., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-01493-0 · Cited by 23 · see citing works

Hemostasis and thrombosis in older adults

Gharacholou, S. M., & Becker, R. C. (2009) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-009-0308-4 · Cited by 23 · see citing works

Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice

Oishi, K., Koyanagi, S., & Ohkura, N. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.09.003 · Cited by 22 · see citing works

Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression

Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., & Yatomi, Y. (2017) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.37663 · Cited by 22 · see citing works

Promising protein biomarkers in the early diagnosis of Alzheimer’s disease

Sharma, L. K., Sharma, A., Kumar, D., Asthana, M. K., Lalhlenmawia, H., Kumar, A., Bhattacharyya, S., & Kumar, D. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-021-00847-9 · Cited by 22 · see citing works

Glucocorticoid-Responsive Tissue Plasminogen Activator (tPA) and Its Inhibitor Plasminogen Activator Inhibitor-1 (PAI-1): Relevance in Stress-Related Psychiatric Disorders

Mennesson, M., & Revest, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054496 · Cited by 27 · see citing works

Coagulation and Fibrinolysis are in Balance After Moderate Exercise in Middle-aged Participants

Menzel, K., & Hilberg, T. (2008) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029608326306 · Cited by 21 · see citing works

Review of evidence implicating the plasminogen activator system in blood-brain barrier dysfunction associated with Alzheimer’s disease

Tang, M.-Y., Gorin, F. A., & Lein, P. J. (2022) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2022.05 · Cited by 20 · see citing works

Influence of ACE I/D Polymorphism on Circulating Levels of Plasminogen Activator Inhibitor 1, D-Dimer, Ultrasensitive C-Reactive Protein and Transforming Growth Factor β1 in Patients Undergoing Hemodialysis

de Carvalho, S. S., Silva, A. C. S. E., Sabino, A. D. P., Evangelista, F. C. G., Gomes, K. B., Dusse, L. M. S., & Rios, D. R. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150613 · Cited by 20 · see citing works

Measuring the mechanical properties of blood clots formed via the tissue factor pathway of coagulation

Foley, J. H., Butenas, S., Mann, K. G., & Brummel‐Ziedins, K. E. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2011.12.036 · Cited by 19 · see citing works

Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish

Khan, A., Fahad, T. M., Akther, T., Zaman, T., Hasan, M. F., Khan, M. R. I., Islam, M. S., & Kishi, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16171 · Cited by 19 · see citing works

Risk factors of thrombosis in Chinese subjects with acute promyelocytic leukemia

Zhang, X., & Guo, X. (2021) · Thrombosis Journal · doi:10.1186/s12959-021-00294-7 · Cited by 19 · see citing works

Plasminogen Activator Inhibitor-1 in Aging

Takeshita, K., Saito, H., & Yamamoto, K. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0034-1384635 · Cited by 70 · see citing works

Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, "Klotho" Mouse

Takeshita, K., Yamamoto, K., Ito, M., Kondo, T., Matsushita, T., Hirai, M., Kojima, T., Nishimura, M., Nabeshima, Y., Loskutoff, D. J., et al. (2002) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2002-36699 · Cited by 86 · see citing works

REVIEW: Plasminogen Activator Inhibitor‐1 (PAI‐1): A Key Factor Linking Fibrinolysis and Age‐Related Subclinical and Clinical Conditions

Cesari, M., Pahor, M., & Incalzi, R. A. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00171.x · Cited by 451 · see citing works

Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals

Yamamoto, K., Takeshita, K., Shimokawa, T., Yi, H., Isobe, K., Loskutoff, D. J., & Saito, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022608799 · Cited by 163 · see citing works

A contemporary review of plasminogen activator inhibitor 1 in cardiovascular disease and broader disease state implications

Becerra, M., Soogoor, N., Vu, J., Wortley, J., & Sathyamoorthy, M. (2026) · Blood Vessels Thrombosis & Hemostasis · doi:10.1016/j.bvth.2026.100141 · Cited by 1 · see citing works