CoChat
Sign Up
Cited by 223Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsPlatelet Disorders and Treatments

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Induction of Thrombosis in a Mouse Model by IgG, IgM and IgA Immunoglobulins from Patients with the Antiphospholipid Syndrome

Pierangeli, Silva S, Liu, Xiao Wei, Barker, John H, Anderson, Gary, Harris, E Nigel·1995·Thrombosis and Haemostasis
DOI 10.1055/s-0038-1649940
Open this paper in CoChat — free account

Abstract

Antiphospholipid syndrome is a disorder of recurrent thrombosis and pregnancy losses associated with production of anticardiolipin antibodies and lupus anticoagulant positivity. Recently, we have adapted a mouse model of induced venous thrombosis to study the role of autoantibodies in thrombus formation. To determine whether immunoglobulins from patients with the antiphospholipid syndrome play a role in thrombosis, we injected groups of CDI mice either with immunoglobulins purified from seven patients with the antiphospholipid syndrome (nine preparations studied: four IgG, three IgM and two IgA) or with immunoglobulins of the same isotype from healthy controls. Seventy-two h after injection, a non-occlusive thrombus was induced in the femoral veins of experimental mice by a pinch injury; the thrombus areas as well as times of formation and disappearance of the thrombi were measured. Eight of the nine antiphospholipid syndrome immunoglobulin preparations caused a significant increase in mean thrombus area and a significant delay in mean thrombus disappearance time as compared with normal controls. To determine whether anticardiolipin antibodies might be involved, separate groups of mice were injected with affinity-purified IgG (n = 2) or IgM (n = 2) anticardiolipin antibodies or with normal immunoglobulins of the same isotype, and the effects on thrombus formation compared. Mean thrombus area and mean disappearance times were again significantly increased in all four groups injected with affinity-purified antibodies. This is the first study to show that anticardiolipin antibodies of IgG, IgM and IgA isotypes may play a role in thrombosis in vivo.

Overview

Integrity signals

Registry

Crossref · 10.1055/s-0038-1649940

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 223

Related

See all

Metadata

Authors
Pierangeli, S. S., Liu, X. W., Barker, J. H., Anderson, G., & Harris, E. N.
Affiliations
  • The Antiphospholipid Standardization Laboratory, Louisville, KY, USA
  • The Department of Medicine, Division of Rheumatology, Louisville, KV, USA
  • The Department of Surgery, Louisville, KY, USA
  • University of Louisville (US)
ORCID
Venue
Thrombosis and Haemostasis
Publisher
Georg Thieme Verlag KG
Published
1995
Volume
74
Issue
05
Pages
1361-1367
ISSN
  • 0340-6245 (ISSN-L)
  • 2567-689X
DOI
10.1055/s-0038-1649940
OpenAlex
W167774609
Cited by
223
References
45
Citations by year
2026: 3 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 13
FWCI
5.82
Type
journal article
Language
en
Open access
closed
Locations
  • Thrombosis and Haemostasis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
Keywords
antiphospholipid syndrome, anticardiolipin antibodies, thrombosis, IgG, immunoglobulin M, immunoglobulin A, autoantibodies, venous thrombosis, mouse model, ICR mice, lupus anticoagulant, thrombus formation
MeSH terms
Animals, Femoral Vein, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunization, Passive, Male, Thrombosis, Antiphospholipid Syndrome, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review