The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Induction of Thrombosis in a Mouse Model by IgG, IgM and IgA Immunoglobulins from Patients with the Antiphospholipid Syndrome
Abstract
Antiphospholipid syndrome is a disorder of recurrent thrombosis and pregnancy losses associated with production of anticardiolipin antibodies and lupus anticoagulant positivity. Recently, we have adapted a mouse model of induced venous thrombosis to study the role of autoantibodies in thrombus formation. To determine whether immunoglobulins from patients with the antiphospholipid syndrome play a role in thrombosis, we injected groups of CDI mice either with immunoglobulins purified from seven patients with the antiphospholipid syndrome (nine preparations studied: four IgG, three IgM and two IgA) or with immunoglobulins of the same isotype from healthy controls. Seventy-two h after injection, a non-occlusive thrombus was induced in the femoral veins of experimental mice by a pinch injury; the thrombus areas as well as times of formation and disappearance of the thrombi were measured. Eight of the nine antiphospholipid syndrome immunoglobulin preparations caused a significant increase in mean thrombus area and a significant delay in mean thrombus disappearance time as compared with normal controls. To determine whether anticardiolipin antibodies might be involved, separate groups of mice were injected with affinity-purified IgG (n = 2) or IgM (n = 2) anticardiolipin antibodies or with normal immunoglobulins of the same isotype, and the effects on thrombus formation compared. Mean thrombus area and mean disappearance times were again significantly increased in all four groups injected with affinity-purified antibodies. This is the first study to show that anticardiolipin antibodies of IgG, IgM and IgA isotypes may play a role in thrombosis in vivo.
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“Moreover, elevated titres of IgA isotypes have been shown to be associated with thrombosis [10, 14–16].”
From Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus (2021) · cites this paper as [14]
Citations
Cites
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor
Galli, M., Barbui, T., Comfurius, P., Maassen, C., Hemker, H. C., Zwaal, R. F. A., Bevers, E. M., Baets, M. H. D., & Vriesman, P. J. C. V. B. (1990) · The Lancet · doi:10.1016/0140-6736(90)91374-j · Cited by 1,266
Love, P. E., & Santoro, S. A. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-9-682 · Cited by 1,095
Thrombosis, Recurrent Fetal Loss, and Thrombocytopenia
Harris, E. N. (1986) · Archives of Internal Medicine · doi:10.1001/archinte.1986.00360230069012 · Cited by 546
Self-citationMatsuura, E., Igarashi, Y., Yasuda, T., Triplett, D. A., & Koike, T. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.457 · Cited by 528
Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis
Ginsburg, K. S., Liang, M. H., Newcomer, L., Goldhaber, S. Z., Schur, P. H., Hennekens, C. H., & Stampfer, M. J. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-12-997 · Cited by 526
The Catastrophic Antiphospholipid Syndrome
Rodríguez‐Pintó, I., Espinosa, G., & Cervera, R. (2014) · Rare diseases of the immune system · doi:10.1007/978-3-319-11044-8_20 · Cited by 493
Oosting, J. D., Derksen, R. H. W. M., Bobbink, I. W. G., Hackeng, T. M., Bouma, B. N., & de Groot, P. G. (1993) · Blood · doi:10.1182/blood.v81.10.2618.2618 · Cited by 487
Immunology and clinical importance of antiphospholipid antibodies
McNeil, H. P., Chesterman, C. N., & Krilis, S. A. (1991) · Advances in immunology · doi:10.1016/s0065-2776(08)60777-4 · Cited by 481
Blank, M., Cohen, J., Toder, V., & Shoenfeld, Y. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3069 · Cited by 453
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Complement C3 Activation Is Required for Antiphospholipid Antibody-induced Fetal Loss
Holers, V. M., Girardi, G., Mo, L., Guthridge, J. M., Molina, H. D., Pierangeli, S. S., Espinola, R. G., Xiaowei, L. E., Mao, D., Vialpando, C. G., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.200116116 · Cited by 625
Self-citationRitis, K., Doumas, M. N., Mastellos, D. C., Micheli, A., Giaglis, S., Magotti, P., Rafail, S., Kartalis, G., Sideras, P., & Lambris, J. D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4794 · Cited by 492
Pierangeli, S. S., Girardi, G., Vega-Ostertag, M. E., Liu, X., Espinola, R. G., & Salmon, J. E. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21157 · Cited by 362
Self-citationPierangeli, S. S., Colden‐Stanfield, M., Liu, X., Barker, J. H., Anderson, G. L., & Harris, E. N. (1999) · Circulation · doi:10.1161/01.cir.99.15.1997 · Cited by 323
Self-citationAntiphospholipid antibodies and thrombosis
Greaves, M. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10362-8 · Cited by 300
Metadata
- Authors
- Pierangeli, S. S., Liu, X. W., Barker, J. H., Anderson, G., & Harris, E. N.
- Affiliations
- The Antiphospholipid Standardization Laboratory, Louisville, KY, USA
- The Department of Medicine, Division of Rheumatology, Louisville, KV, USA
- The Department of Surgery, Louisville, KY, USA
- University of Louisville (US)
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1995
- Volume
- 74
- Issue
- 05
- Pages
- 1361-1367
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W167774609
- Cited by
- 223
- References
- 45
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 13
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- antiphospholipid syndrome, anticardiolipin antibodies, thrombosis, IgG, immunoglobulin M, immunoglobulin A, autoantibodies, venous thrombosis, mouse model, ICR mice, lupus anticoagulant, thrombus formation
- MeSH terms
- Animals, Femoral Vein, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunization, Passive, Male, Thrombosis, Antiphospholipid Syndrome, Mice
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