Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis

Ginsburg, Katherine S.; Liang, Matthew H.; Newcomer, Laura; Goldhaber, Samuel Z.; Schur, Peter H.; Hennekens, Charles H.; Stampfer, Meir J.

doi:10.7326/0003-4819-117-12-997

Cited by 526Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsAcute Ischemic Stroke Management

Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis

Ginsburg, Katherine S., Liang, Matthew H., Newcomer, Laura, Goldhaber, Samuel Z., Schur, Peter H., Hennekens, Charles H., Stampfer, Meir J.·1992·Annals of Internal Medicine

DOI 10.7326/0003-4819-117-12-997

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Abstract

Objective To determine whether the presence of anticardiolipin antibodies is a risk factor for ischemic stroke and venous thrombosis in healthy adult men. Design A nested, case-control study in a prospective cohort. Setting A nationwide study of physicians. Participants The study sample was drawn from the Physicians' Health Study, a randomized, double-blind, placebo-controlled trial of aspirin and beta-carotene in 22,071 male physicians. At entry, 68% of the participants submitted plasma samples that were subsequently frozen at -80 degrees C. During 60.2 months of follow-up, follow-up for nonfatal outcomes was 99.7% complete and ascertainment of fatal outcomes was 100% complete. We identified men with documented ischemic stroke, deep venous thrombosis of the leg, or pulmonary embolus and for whom a plasma sample was available. A control was matched by age, smoking history, and length of follow-up to each of the 100 patients with ischemic stroke and the 90 patients with deep venous thrombosis or pulmonary embolus. Measurements Plasma samples were assessed for IgG anticardiolipin antibodies by enzyme-linked immunosorbent assay. The mean anticardiolipin antibody titers of the case patients in the two diagnostic groups (ischemic stroke; venous thrombosis or pulmonary embolus) were compared with those of the control groups, and relative risks were calculated for patients in increasing percentile categories of anticardiolipin antibodies by conditional logistic regression. Results T…

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Authors: Ginsburg, K. S., Liang, M. H., Newcomer, L., Goldhaber, S. Z., Schur, P. H., Hennekens, C. H., & Stampfer, M. J.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Liang, Matthew H.
Goldhaber, Samuel Z.
Hennekens, Charles H.
Stampfer, Meir J.
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 1992-12-15
Volume: 117
Issue: 12
Pages: 997-1002
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-117-12-997
OpenAlex: W1491481195
Cited by: 526
References: 49
Citations by year: 2025: 2 · 2024: 7 · 2023: 5 · 2022: 1 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 10 · 2013: 15 · 2012: 16
FWCI: 16.25
Type: journal article
Language: en
Open access: closed
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA042182, CA 42182)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (P60AR036308, AR-36308, AR-07530, T32AR007530)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords: anticardiolipin antibodies, ischemic stroke, venous thrombosis, deep vein thrombosis, pulmonary embolism, thrombophilia, risk factors, IgG, male physicians, Physicians' Health Study, aspirin, beta-carotene, anticoagulation, stroke prevention, antithrombotic therapy
MeSH terms: Adult, Aged, Aged, 80 and over, Brain Ischemia, Enzyme-Linked Immunosorbent Assay, Humans, Male, Middle Aged, Prospective Studies, Pulmonary Embolism, Risk Factors, Statistics as Topic, Thrombophlebitis, Case-Control Studies, Antibodies, Anticardiolipin

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Anticardiolipin Antibodies and the Risk for Ischemic Stroke and Venous Thrombosis

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