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Effect of Plasma Dilution on Adsorption of Fibrinogen to Solid Surfaces
Abstract
Summary: The adsorption of various plasma proteins to three solid surfaces has been studied as a function of plasma concentration. Albumin adsorption on glass showed no dependence on plasma concentration and increased to a plateau value on both polyethylene and siliconized glass. Immunoglobulin G (IgG) adsorption showed no dependence on plasma concentration on any surface. Fibrinogen adsorption increased with plasma concentration and then decreased, the maximum occurring at about 1% normal plasma concentration and varying somewhat with the surface. On glass the kinetics of fibrinogen adsorption was dependent on plasma concentration: at concentrations less than the adsorption maximum, the kinetics was conventional, with adsorption increasing onto a plateau; at concentrations greater than the adsorption maximum, kinetics curves also showed maxima the position of which shifted to longer times as plasma concentration decreased. These data are interpreted in terms of competitive adsorption between fibrinogen and other, as yet unidentified species in plasma. The data reported are in general agreement with the model of Vroman (12) for plasma-surface interactions which holds that initially adsorbed fibrinogen is later replaced by high molecular weight kininogen (HMWK), the rate of replacement depending on the relative activity of the surface in promoting coagulation.
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Citations
Cited by
Protein adsorption in three dimensions
Vogler, E. A. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.10.059 · Cited by 585
Proteins, platelets, and blood coagulation at biomaterial interfaces
Xu, L.-C., Bauer, J. W., & Siedlecki, C. A. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2014.09.040 · Cited by 391
The Vroman effect: Competitive protein exchange with dynamic multilayer protein aggregates
Hirsh, S. L., McKenzie, D. R., Nosworthy, N. J., Denman, J. A., Sezerman, O. U., & Bilek, M. M. M. (2013) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2012.10.039 · Cited by 340
Human plasma fibrinogen adsorption and platelet adhesion to polystyrene
Tsai, W.-B., Grunkemeier, J. M., & Horbett, T. A. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199902)44:2<130::aid-jbm2>3.0.co;2-9 · Cited by 329
Feist, P., & Hummon, A. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023537 · Cited by 288
Metadata
- Authors
- Brash, J. L., & ten Hove, P.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 1984
- Volume
- 51
- Issue
- 03
- Pages
- 326-330
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W2432443528
- Cited by
- 193
- References
- 0
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effect of Plasma Dilution on Adsorption of Fibrinogen to Solid Surfaces. https://app.cochat.ai/papers/10.1055/s-0038-1661093
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- Brash, J. L., & ten Hove, P. (1984). Effect of Plasma Dilution on Adsorption of Fibrinogen to Solid Surfaces. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0038-1661093
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
