Cited by 391Polymer Surface Interaction StudiesSurface Modification and SuperhydrophobicityBone Tissue Engineering Materials

Proteins, platelets, and blood coagulation at biomaterial interfaces

Open access
Xu, Li-Chong, Bauer, James W., Siedlecki, Christopher A.·2014·Colloids and Surfaces B: Biointerfaces

Abstract

Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.

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Crossref · 10.1016/j.colsurfb.2014.09.040

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Research works printed but not linked: 6

  1. [35]Asch E Podack E Vitronectin binds to activated human platelets and plays a role in platelet aggregation The Journal of Clinical Investigation 85 1372 1378 10.1172/jci114581 1990 1692034 PMC296582 · DOI
  2. [181]Kirschner CM Brennan AB Clarke DR Annual Review of Materials Research, Vol 42 Vol. 42 Annual Review of Materials Research 211 229 2012
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  5. [201]Jenny NS Mann KG Loscalzo J Schafer A Thrombosis and Hemorrhage 1 21 Lippincott, Williams & Wilkins 2002
  6. [212]Vogler EA Contact Activation of the Plasma Coagulation Cascade.1. Procoagulant Surface-Chemistry and Energy Journal of Biomedical Materials Research 29 1005 1016 1995 7593031

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Authors
Xu, L.-C., Bauer, J. W., & Siedlecki, C. A.
Affiliations
Pennsylvania State University (US)
Corresponding author
Siedlecki, Christopher A.
Venue
Colloids and Surfaces B: Biointerfaces
Publisher
Elsevier BV
Published
2014-12
Volume
124
Pages
49-68
ISSN
0927-7765 (ISSN-L)
OpenAlex
W1994506733
Cited by
391
References
225
Citations by year
2026: 34 · 2025: 33 · 2024: 28 · 2023: 32 · 2022: 41 · 2021: 52 · 2020: 47 · 2019: 45 · 2018: 36 · 2017: 22 · 2016: 15 · 2015: 5
FWCI
5.51
Type
journal article
Language
en
Open access
Locations
  • Colloids and Surfaces B Biointerfaces (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (RO1 HL69965)
  • National Science Foundation (DMR-0804873)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Surface Modification and Superhydrophobicity
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
coagulation, platelet adhesion, biomaterial interfaces, biomedical implants, surface engineering, surface texturing, chemical patterning, surface characterization, protein adsorption
MeSH terms
Biocompatible Materials, Blood Coagulation, Blood Platelets, Fibrinogen, Humans, Proteins, Surface Properties

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