Proteins, platelets, and blood coagulation at biomaterial interfaces
Open accessAbstract
Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.
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Creating a submicron-textured surface can reduce accessible contact area for platelets and bacteria, minimizing adsorption opportunities.
“Creating a submicron-textured surface can dramatically reduce the accessible contact area for platelets or bacteria to interact with the surface, thereby minimizing the opportunities for bacteria and platelet adsorption.102–104”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [104]
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Flagged first, then by citations
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Cited by
Sorted by citations
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
- Authors
- Xu, L.-C., Bauer, J. W., & Siedlecki, C. A.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Siedlecki, Christopher A.
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 124
- Pages
- 49-68
- ISSN
- 0927-7765 (ISSN-L)
- PMC
- PMC5001692
- OpenAlex
- W1994506733
- Cited by
- 391
- References
- 225
- Citations by year
- 2026: 34 · 2025: 33 · 2024: 28 · 2023: 32 · 2022: 41 · 2021: 52 · 2020: 47 · 2019: 45 · 2018: 36 · 2017: 22 · 2016: 15 · 2015: 5
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (RO1 HL69965)
- National Science Foundation (DMR-0804873)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Surface Modification and Superhydrophobicity
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- coagulation, platelet adhesion, biomaterial interfaces, biomedical implants, surface engineering, surface texturing, chemical patterning, surface characterization, protein adsorption
- MeSH terms
- Biocompatible Materials, Blood Coagulation, Blood Platelets, Fibrinogen, Humans, Proteins, Surface Properties
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