The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Pathogenesis of Acute Respiratory Distress Syndrome
Open accessAbstract
Acute respiratory distress syndrome (ARDS) is a syndrome of acute respiratory failure caused by noncardiogenic pulmonary edema. Despite five decades of basic and clinical research, there is still no effective pharmacotherapy for this condition and the treatment remains primarily supportive. It is critical to study the molecular and physiologic mechanisms that cause ARDS to improve our understanding of this syndrome and reduce mortality. The goal of this review is to describe our current understanding of the pathogenesis and pathophysiology of ARDS. First, we will describe how pulmonary edema fluid accumulates in ARDS due to lung inflammation and increased alveolar endothelial and epithelial permeabilities. Next, we will review how pulmonary edema fluid is normally cleared in the uninjured lung, and describe how these pathways are disrupted in ARDS. Finally, we will explain how clinical trials and preclinical studies of novel therapeutic agents have further refined our understanding of this condition, highlighting, in particular, the study of mesenchymal stromal cells in the treatment of ARDS.
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Cites
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Self-citationACUTE RESPIRATORY DISTRESS IN ADULTS
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Cited by
Nalbandian, A., Sehgal, K., Gupta, A., Madhavan, M. V., McGroder, C., Stevens, J. S., Cook, J. R., Nordvig, A. S., Shalev, D., Sehrawat, T. S., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01283-z · Cited by 4,862
Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury
Zhou, X., & Liao, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.779620 · Cited by 153
Role of gut microbes in acute lung injury/acute respiratory distress syndrome
Ren, Z., Zheng, Z., & Feng, X. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2440125 · Cited by 48
Spampinato, M., Carota, G., Sferrazzo, G., Fuochi, V., Distefano, A., Ronsisvalle, S., Sipala, F., Giuffrida, R., Furneri, P. M., Di Rosa, M., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122845 · Cited by 14
“Inflammatory diseases include ALI (acute lung injury) or ARDS (acute respiratory distress syndrome), which represents one of the critical pulmonary diseases involving widespread inflammation inducing epithelial injury and lung dysfunction [9,10].”
Background
Metadata
- Authors
- Huppert, L., Matthay, M., & Ware, L.
- Venue
- Seminars in Respiratory and Critical Care Medicine
- Publisher
- Georg Thieme Verlag KG
- Published
- 2019-02
- Volume
- 40
- Issue
- 01
- Pages
- 031-039
- ISSN
- 1069-3424 (ISSN-L)
- 1098-9048
- OpenAlex
- W2944584167
- Cited by
- 459
- References
- 131
- FWCI
- 33.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huppert, L., Matthay, M., & Ware, L. (2019). Pathogenesis of Acute Respiratory Distress Syndrome. Seminars in Respiratory and Critical Care Medicine. https://doi.org/10.1055/s-0039-1683996
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
