The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure
Open accessAbstract
In late December 2019 an outbreak of a novel coronavirus (SARS-CoV-2) causing severe pneumonia (COVID-19) was reported in Wuhan, Hubei Province, China. A common finding in most COVID-19 patients is high D-dimer levels which are associated with a worse prognosis. We aimed to evaluate coagulation abnormalities via traditional tests and whole blood thromboelastometry profiles in a group of 22 (mean age 67 ± 8 years, M:F 20:2) consecutive patients admitted to the Intensive Care Unit of Padova University Hospital for acute respiratory failure due to COVID-19. Cases showed significantly higher fibrinogen and D-dimer plasma levels versus healthy controls (p < 0.0001 in both comparisons). Interestingly enough, markedly hypercoagulable thromboelastometry profiles were observed in COVID-19 patients, as reflected by shorter Clot Formation Time (CFT) in INTEM (p = 0.0002) and EXTEM (p = 0.01) and higher Maximum Clot Firmness (MCF) in INTEM, EXTEM and FIBTEM (p < 0.001 in all comparisons). In conclusion, COVID-19 patients with acute respiratory failure present a severe hypercoagulability rather than consumptive coagulopathy. Fibrin formation and polymerization may predispose to thrombosis and correlate with a worse outcome.
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Cites
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263
Tang, N., Li, D., Wang, X., & Sun, Z. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14768 · Cited by 5,662
Tang, N., Bai, H., Chen, X., Gong, J., Li, D., & Sun, Z. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14817 · Cited by 3,559
Whole blood coagulation thrombelastographic profiles employing minimal tissue factor activation
Sørensen, B., Johansen, P., Christiansen, K., Woelke, M., & Ingerslev, J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00075.x · Cited by 352
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Peculiar whole blood rotation thromboelastometry (Rotem) profile in 40 sideropenic anaemia patients
Spiezia, L., Radu, C. M., Marchioro, P., Bertini, D., Rossetto, V., Castelli, M., Pagnan, A., Sørensen, B., & Simioni, P. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-04-0243 · Cited by 90
Self-citationMiddle East Respiratory Syndrome Virus Pathogenesis
Singh, S. K. (2016) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0036-1584796 · Cited by 61
Cited by
Merkler, A. E., Parikh, N. S., Mir, S., Gupta, A., Kamel, H., Lin, E., Lantos, J., Schenck, E. J., Goyal, P., Bruce, S. S., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.2730 · Cited by 940
Liao, D., Zhou, F., Luo, L., Xu, M., Wang, H., Xia, J., Gao, Y., Cai, L., Wang, Z., Yin, P., et al. (2020) · The Lancet Haematology · doi:10.1016/s2352-3026(20)30217-9 · Cited by 513
da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T. (2021) · Clinical and Experimental Medicine · doi:10.1007/s10238-020-00650-3 · Cited by 475
Arterial Thrombosis in Coronavirus Disease 2019 Patients: A Rapid Systematic Review
Cheruiyot, I., Kipkorir, V., Ngure, B., Misiani, M., Munguti, J., & Ogeng'o, J. (2021) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2020.08.087 · Cited by 434
He, L., Mäe, M. A., Muhl, L., Sun, Y., Pietilä, R., Nahar, K., Liébanas, E. V., Fagerlund, M. J., Oldner, A., Liu, J., et al. (2020) · doi:10.1101/2020.05.11.088500 · Cited by 116
Metadata
- Authors
- Spiezia, L., Boscolo, A., Poletto, F., Cerruti, L., Tiberio, I., Campello, E., Navalesi, P., & Simioni, P.
- Venue
- Thrombosis and Haemostasis
- Publisher
- Georg Thieme Verlag KG
- Published
- 2020-04-21
- Volume
- 120
- Issue
- 06
- Pages
- 998-1000
- ISSN
- 0340-6245 (ISSN-L)
- 2567-689X
- OpenAlex
- W3016319555
- Cited by
- 699
- References
- 7
- FWCI
- 19.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Spiezia, L., Boscolo, A., Poletto, F., Cerruti, L., Tiberio, I., Campello, E., Navalesi, P., & Simioni, P. (2020). COVID-19-Related Severe Hypercoagulability in Patients Admitted to Intensive Care Unit for Acute Respiratory Failure. Thrombosis and Haemostasis. https://doi.org/10.1055/s-0040-1710018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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