Cited by 123Liver Disease Diagnosis and TreatmentNutritional Studies and DietAlcohol Consumption and Health Effects

Effects of mediterranean diet in patients with nonalcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression analysis of randomized controlled trials

Kawaguchi, Takumi, Charlton, Michael, Kawaguchi, Atsushi, Yamamura, Sakura, Nakano, Dan, Tsutsumi, Tsubasa, Zafer, Maryam, Torimura, Takuji·2021·Seminars in Liver Disease

Abstract

Abstract We conducted a meta-analysis to investigate the effects of the Mediterranean Diet (Med-Diet) on hepatic steatosis and insulin resistance in patients with nonalcoholic fatty liver disease (NAFLD). Six randomized controlled trials were selected for the meta-analysis (sample size: 250 participants). In the meta-analysis, there was no significant difference in body mass index and waist circumference between the Med-Diet and control groups. Med-Diet significantly reduced fatty liver index (FLI) compared with the control diet (standard mean difference [SMD]: –1.06; 95% CI: –1.95 to –0.17; p = 0.02). Med-Diet significantly reduced homeostasis model assessment of insulin resistance (HOMA-IR) compared with the control diet (SMD: –0.34; 95% CI: –0.65 to –0.03; p = 0.03). Similarly, a meta-regression analysis using age showed that Med-Diet significantly reduced FLI and HOMA-IR (95% CI: –0.956 to –0.237, p = 0.001 and 95% CI: –0.713 to –0.003, p = 0.048, respectively). This meta-analysis demonstrated that Med-Diet improved hepatic steatosis and insulin resistance in patients with NAFLD. Thus, Med-Diet is a beneficial pharmaconutritional therapy in patients with NAFLD.

Integrity signals

Registry

Crossref · 10.1055/s-0041-1723751

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kawaguchi, T., Charlton, M., Kawaguchi, A., Yamamura, S., Nakano, D., Tsutsumi, T., Zafer, M., & Torimura, T.
Affiliations
  • Kurume University (JP)
  • University of Chicago (US)
  • Saga University (JP)
Corresponding author
Charlton, Michael
Venue
Seminars in Liver Disease
Published
2021-06-19
Volume
41
Issue
03
Pages
225-234
ISSN
  • 0272-8087 (ISSN-L)
  • 1098-8971
OpenAlex
W3171675307
Cited by
122
References
48
Citations by year
2026: 29 · 2025: 36 · 2024: 21 · 2023: 19 · 2022: 14 · 2021: 3
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Liver Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Agency for Medical Research and Development (JP20fk0210040)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
Mediterranean diet, non-alcoholic fatty liver disease, hepatic steatosis, insulin resistance, fatty liver index, HOMA-IR, dietary intervention
MeSH terms
Humans, Insulin Resistance, Regression Analysis, Randomized Controlled Trials as Topic, Diet, Mediterranean, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review