Systematic Review of Approaches to Preserve Machine Learning Performance in the Presence of Temporal Dataset Shift in Clinical Medicine
Open accessAbstract
Objective The change in performance of machine learning models over time as a result of temporal dataset shift is a barrier to machine learning-derived models facilitating decision-making in clinical practice. Our aim was to describe technical procedures used to preserve the performance of machine learning models in the presence of temporal dataset shifts. Methods Studies were included if they were fully published articles that used machine learning and implemented a procedure to mitigate the effects of temporal dataset shift in a clinical setting. We described how dataset shift was measured, the procedures used to preserve model performance, and their effects. Results Of 4,457 potentially relevant publications identified, 15 were included. The impact of temporal dataset shift was primarily quantified using changes, usually deterioration, in calibration or discrimination. Calibration deterioration was more common (n = 11) than discrimination deterioration (n = 3). Mitigation strategies were categorized as model level or feature level. Model-level approaches (n = 15) were more common than feature-level approaches (n = 2), with the most common approaches being model refitting (n = 12), probability calibration (n = 7), model updating (n = 6), and model selection (n = 6). In general, all mitigation strategies were successful at preserving calibration but not uniformly successful in preserving discrimination. Conclusion There was limited research in preserving the performance of machine learning models in the presence of temporal dataset shift in clinical medicine. Future research could focus on the impact of dataset shift on clinical decision making, benchmark the mitigation strategies on a wider range of datasets and tasks, and identify optimal strategies for specific settings.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PRISMA-P Group, Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015) · Systematic Reviews · doi:10.1186/2046-4053-4-1 · Cited by 26,223 · see citing works
MIMIC-III, a freely accessible critical care database
Johnson, A. E. W., Pollard, T. J., Shen, L., Lehman, L.-W. H., Feng, M., Ghassemi, M., Moody, B., Szolovits, P., Anthony Celi, L., & Mark, R. G. (2016) · Scientific Data · doi:10.1038/sdata.2016.35 · Cited by 8,141 · see citing works
The unified medical language system (UMLS): integrating biomedical terminology
Bodenreider, O. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh061 · Cited by 4,356 · see citing works
A survey on concept drift adaptation
Gama, J., Žliobaitė, I., Bifet, A., Pechenizkiy, M., & Bouchachia, A. (2014) · ACM Computing Surveys · doi:10.1145/2523813 · Cited by 3,735 · see citing works
Scalable and accurate deep learning with electronic health records
Rajkomar, A., Oren, E., Chen, K., Dai, A. M., Hajaj, N., Hardt, M., Liu, P. J., Liu, X., Marcus, J., Sun, M., et al. (2018) · npj Digital Medicine · doi:10.1038/s41746-018-0029-1 · Cited by 2,648 · see citing works
Self-citationScalable and accurate deep learning with electronic health records.
Rajkomar, A., Oren, E., Chen, K., Dai, A. M., Hajaj, N., Hardt, M., Liu, P. J., Liu, X., Marcus, J., Sun, M., et al. (2018) · eScholarship (California Digital Library) · Cited by 2,242 · see citing works
Self-citationDataset Shift in Machine Learning
(2008) · doi:10.7551/mitpress/9780262170055.001.0001 · Cited by 1,553 · see citing works
A unifying view on dataset shift in classification
Moreno-Torres, J. G., Raeder, T., Alaiz-Rodríguez, R., Chawla, N. V., & Herrera, F. (2012) · Pattern Recognition · doi:10.1016/j.patcog.2011.06.019 · Cited by 1,029 · see citing works
Luo, W., Phung, D., Tran, T., Gupta, S., Rana, S., Karmakar, C., Shilton, A., Yearwood, J., Dimitrova, N., Ho, T. B., et al. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.5870 · Cited by 988 · see citing works
Multitask learning and benchmarking with clinical time series data
Harutyunyan, H., Khachatrian, H., Kale, D. C., Ver Steeg, G., & Galstyan, A. (2019) · Scientific Data · doi:10.1038/s41597-019-0103-9 · Cited by 958 · see citing works
Artificial intelligence, bias and clinical safety
Challen, R., Denny, J., Pitt, M., Gompels, L., Edwards, T., & Tsaneva-Atanasova, K. (2019) · BMJ Quality & Safety · doi:10.1136/bmjqs-2018-008370 · Cited by 956 · see citing works
Arjovsky, M., Bottou, L., Gulrajani, I., & Lopez-Paz, D. (2019) · arXiv · doi:10.48550/arxiv.1907.02893 · Cited by 927 · see citing works
Two further applications of a model for binary regression
COX, D. R. (1958) · Biometrika · doi:10.1093/biomet/45.3-4.562 · Cited by 556 · see citing works
Changing how we think about healthcare improvement
Braithwaite, J. (2018) · BMJ · doi:10.1136/bmj.k2014 · Cited by 524 · see citing works
CRIB II: an update of the clinical risk index for babies score
Parry, G. J., Tucker, J. S., & Tarnow‐Mordi, W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13397-1 · Cited by 520 · see citing works
The myth of generalisability in clinical research and machine learning in health care
Futoma, J., Simons, M., Panch, T., Doshi-Velez, F., & Celi, L. A. (2020) · The Lancet Digital Health · doi:10.1016/s2589-7500(20)30186-2 · Cited by 467 · see citing works
Updating methods improved the performance of a clinical prediction model in new patients
Janssen, K. J. M., Moons, K. G. M., Kalkman, C. J., Grobbee, D. E., & Vergouwe, Y. (2007) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.04.018 · Cited by 381 · see citing works
Cutillo, C. M., Sharma, K. R., Foschini, L., Kundu, S., Mackintosh, M., Mandl, K. D., MI in Healthcare Workshop Working Group, Beck, T., Collier, E., Colvis, C., et al. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0254-2 · Cited by 337 · see citing works
Calibration drift in regression and machine learning models for acute kidney injury
Davis, S. E., Lasko, T. A., Chen, G., Siew, E. D., & Matheny, M. E. (2017) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocx030 · Cited by 312 · see citing works
Invariant Causal Prediction for Nonlinear Models
Heinze‐Deml, C., Peters, J., & Meinshausen, N. (2018) · Journal of Causal Inference · doi:10.1515/jci-2017-0016 · Cited by 198 · see citing works
スマート・データプライニングの概観:過去のプロポーザル,現在のプラン,今後の傾向
Soumya, S., Carlee, J.-W., Ha, S., & Chiang, M. (2013) · ACM Computing Surveys · Cited by 179 · see citing works
A review of statistical updating methods for clinical prediction models
Su, T.-L., Jaki, T., Hickey, G. L., Buchan, I., & Sperrin, M. (2018) · Statistical Methods in Medical Research · doi:10.1177/0962280215626466 · Cited by 147 · see citing works
A nonparametric updating method to correct clinical prediction model drift
Davis, S. E., Greevy, R., Fonnesbeck, C., Lasko, T., Walsh, C. G., & Matheny, M. E. (2019) · J. Am. Medical Informatics Assoc. · doi:10.1093/jamia/ocz127 · Cited by 112 · see citing works
The number needed to benefit: estimating the value of predictive analytics in healthcare
Liu, V. X., Bates, D. W., Wiens, J., & Shah, N. H. (2019) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocz088 · Cited by 59 · see citing works
Self-citationDynamic Prediction Modeling Approaches for Cardiac Surgery
Hickey, G., Grant, S., Caiado, C., Kendall, S., Dunning, J., Poullis, M., Buchan, I. E., & Bridgewater, B. (2013) · Circulation. Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.111.000012 · Cited by 55 · see citing works
Calibration Drift Among Regression and Machine Learning Models for Hospital Mortality.
Davis, S. E., Lasko, T. A., Chen, G., & Matheny, M. E. (2017) · PubMed Central · Cited by 50 · see citing works
Strobl, A. N., Vickers, A. J., CALSTER, B. V., Steyerberg, E. W., Leach, R. J., Thompson, I. M., & Ankerst, D. P. (2015) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2015.05.001 · Cited by 46 · see citing works
Barriers to Achieving Economies of Scale in Analysis of EHR Data: A Cautionary Tale
Sendak, M. P., Balu, S., & Schulman, K. A. (2017) · Applied Clinical Informatics · doi:10.4338/aci-2017-03-cr-0046 · Cited by 45 · see citing works
The Proliferation of Reports on Clinical Scoring Systems
Challener, D. W., Prokop, L. J., & AbuSaleh, O. (2019) · JAMA · doi:10.1001/jama.2019.5284 · Cited by 45 · see citing works
An empirical framework for domain generalization in clinical settings
Zhang, H., Dullerud, N., Seyyed-Kalantari, L., Morris, Q., Joshi, S. D., & Ghassemi, M. (2021) · ACM Conference on Health, Inference, and Learning (CHIL) · doi:10.1145/3450439.3451878 · Cited by 42 · see citing works
Methods for updating a risk prediction model for cardiac surgery: a statistical primer.
Siregar, S., Nieboer, D., Versteegh, M., Steyerberg, E., & Takkenberg, J. (2019) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1093/icvts/ivy338 · Cited by 32 · see citing works
EHRtemporalVariability: delineating temporal data-set shifts in electronic health records
Sáez, C., Gutiérrez‐Sacristán, A., Kohane, I. S., Garcia-Gomez, J. M., & Avillach, P. (2020) · GigaScience · doi:10.1093/gigascience/giaa079 · Cited by 32 · see citing works
Improved Prediction by Dynamic Modeling
Siregar, S., Nieboer, D., Vergouwe, Y., Versteegh, M. I. M., Noyez, L., Vonk, A. B. A., Steyerberg, E. W., & Takkenberg, J. J. M. (2016) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.114.001645 · Cited by 26 · see citing works
Davis, S. E., Greevy, R. A., Lasko, T. A., Walsh, C. G., & Matheny, M. E. (2019) · PubMed Central · Cited by 24 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- [22]22. Adam GA, Chang C-HK, Haibe-Kains B, Goldenberg A. Hidden risks of machine learning applied to healthcare: unintended feedback loops between models and future data causing model degrada- tion. Presented at: Proceedings of the 5th Machine Learning for Healthcare Conference; Proceedings of Machine Learning Re- search. Accessed 2020 at: http://proceedings.mlr.press
- [25]25. Nestor B, McDermott MBA, Boag W, et al. Feature robustness in non-stationary health records: caveats to deployable model performance in common clinical machine learning tasks. Pre- sented at: Proceedings of the 4th Machine Learning for Healthcare Conference. Accessed 2019 at: http://proceedings.mlr.press
- [26]26. Nestor B, McDermott MBA, Chauhan G, et al. Rethinking clinical prediction: why machine learning must consider year of care and feature aggregation. Available at: arXiv:181112583 [csLG] . Accessed 2018
- [28]28. Feng J. Learning how to approve updates to machine learning algorithms in non-stationary settings. Available at: arXiv preprint arXiv:201207278. Accessed 2020
- [32]32. Lu J, Liu A, Dong F, Gu F, Gama J, Zhang G. Learning under concept drift: a review. IEEE Trans Knowl Data Eng 2018;31(12):2346-2363
- [35]35. Schölkopf B, Janzing D, Peters J, Sgouritsa E, Zhang K, Mooij J. On causal and anticausal learning. Presented at: Proceedings of the 29th International Coference on International Conference on Machine Learning; Edinburgh, Scotland. Accessed 2012 at: https://icml.cc/2012/papers/625.pdf
- [36]36. Subbaswamy A, Schulam P, Saria S. Preventing failures due to dataset shift: learning predictive models that transport. Pre- sented at: International Conference on Artificial Intelligence and Statistics (AISTATS); Naha, Japan. Accessed 2019 at: http://pro- ceedings.mlr.press
Cited by
Sorted by citations
Foundation models for generalist medical artificial intelligence
Moor, M., Banerjee, O., Abad, Z. S. H., Krumholz, H. M., Leskovec, J., Topol, E. J., & Rajpurkar, P. (2023) · Nature · doi:10.1038/s41586-023-05881-4 · Cited by 2,028 · see citing works
“Existing medical AI models struggle with distribution shifts, in which distributions of data shift owing to changes in technologies, procedures, settings or populations 37,38 .”
BackgroundAlgorithmic fairness in artificial intelligence for medicine and healthcare
Chen, R. J., Wang, J. J., Williamson, D. F. K., Chen, T. Y., Lipkova, J., Lu, M. Y., Sahai, S., & Mahmood, F. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01056-8 · Cited by 750 · see citing works
Data drift in medical machine learning: implications and potential remedies
Sahiner, B., Chen, W., Samala, R. K., & Petrick, N. (2023) · The British Journal of Radiology · doi:10.1259/bjr.20220878 · Cited by 279 · see citing works
Guo, L. L., Pfohl, S. R., Fries, J., Johnson, A. E. W., Posada, J., Aftandilian, C., Shah, N., & Sung, L. (2022) · Scientific Reports · doi:10.1038/s41598-022-06484-1 · Cited by 103 · see citing works
“The heterogeneity of impact by temporal dataset shift as characterized by our baseline experiment echoes the mixed results in model deterioration across several studies that made predictions of clinical outcomes in various populations 5 .”
ResultSelf-citationMonitoring performance of clinical artificial intelligence in health care: a scoping review
Andersen, E. S., Birk-Korch, J. B., Hansen, R. S., Fly, L. H., Röttger, R., Arcani, D. M. C., Brasen, C. L., Brandslund, I., & Madsen, J. S. (2024) · JBI Evidence Synthesis · doi:10.11124/jbies-24-00042 · Cited by 73 · see citing works
Sustainable deployment of clinical prediction tools—a 360° approach to model maintenance
Davis, S. E., Embí, P. J., & Matheny, M. E. (2024) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocae036 · Cited by 46 · see citing works
Advances in Machine Learning Approaches to Heart Failure with Preserved Ejection Fraction
Ahmad, F. S., Luo, Y., Wehbe, R. M., Thomas, J. D., & Shah, S. J. (2022) · Heart Failure Clinics · doi:10.1016/j.hfc.2021.12.002 · Cited by 34 · see citing works
Open questions and research gaps for monitoring and updating AI-enabled tools in clinical settings
Davis, S. E., Walsh, C. G., & Matheny, M. E. (2022) · Frontiers in Digital Health · doi:10.3389/fdgth.2022.958284 · Cited by 33 · see citing works
El Arab, R. A., Mustafa, M. H., Almagharbeh, W. T., Saleem, N. H., Al Abdulmohsen, S., Boathab, R., & Bu Washl, M. (2026) · Healthcare · doi:10.3390/healthcare14111459 · Cited by 4 · see citing works
“…of the present synthesis is to characterise recurrent patterns, tensions, and maturity gaps within the published review literature rather than to provide pooled estimates or definitive field-wide estimates of the prevalence, magnitude, or certainty of post-deployment harms [18,20,33,41].”
Influential
- Authors
- Guo, L. L., Pfohl, S. R., Fries, J., Posada, J., Fleming, S. L., Aftandilian, C., Shah, N., & Sung, L.
- Affiliations
- Hospital for Sick Children (CA)
- Stanford University (US)
- Corresponding author
- Sung, Lillian
- ORCID
- Venue
- Applied Clinical Informatics
- Publisher
- Georg Thieme Verlag KG
- Published
- 2021-08
- Volume
- 12
- Issue
- 04
- Pages
- 808-815
- ISSN
- 1869-0327 (ISSN-L)
- PMC
- PMC8410238
- OpenAlex
- W3196529262
- Cited by
- 96
- References
- 34
- Citations by year
- 2026: 29 · 2025: 29 · 2024: 12 · 2023: 14 · 2022: 12
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Applied Clinical Informatics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning in Healthcare
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Keywords
- concept drift, clinical decision support, probability calibration, model updating, model selection
- MeSH terms
- Clinical Decision-Making, Machine Learning, Cognition, Clinical Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review