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Cited by 2

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Dilemmas in the Management of Acute TBI: A Prospective Observational Study of Anterior Pituitary Dysfunction and Its Correlation with Outcome

Choudhary, Ajay, Sobti, Shivender, Dev, Nirankar, Kulshreshtha, Bindu, Sharma, Rajesh, Kaushik, Kaviraj, Kumar, Ashok·2024·Indian Journal of Neurotrauma
DOI 10.1055/s-0043-1769802
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Abstract

Background The frequency and pattern of endocrinal abnormalities among patients with traumatic brain injury occur more frequently than previously suspected. Objective The aim of this study was to assess anterior pituitary dysfunction in patients with moderate-to-severe traumatic brain injury and outcome after treatment. Materials and Methods One hundred patients with moderate-to-severe head injury presenting within 48 hours of injury were enrolled. Blood samples of all patients were taken for the hormonal assay at second day, at 2 weeks, 1 month, 3 months, and 6 months. Patients were evaluated by Glasgow coma scale (GCS), Glasgow outcome score (GOS), and hormone profile. Results The median GCS score was 10/15. Forty-four patients were operated and 56 patients were managed medically. Seven operated patients expired; 30 patients had good recovery. In conservative group, 46 patients had good outcome and two patients died. Cortisol and thyroid hormone values were changed prominently, followed by prolactin and growth hormone. On univariate analysis, association of GOS with fT3, fT4, serum prolactin, and serum cortisol was seen. On multivariate analysis, strong correlation of GOS with f T4 values was seen (p = 0.008) Conclusion Most of the hormonal deficiency occurs in immediate phase. Hormonal screening should be done to improve long term outcome.

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Research works printed but not linked: 19

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Cited by

Metadata

Authors
Choudhary, A., Sobti, S., Dev, N., Kulshreshtha, B., Sharma, R., Kaushik, K., & Kumar, A.
Affiliations
  • Department of Neurosurgery, ABVIMS and Dr. RML Hospital, New Delhi, India
  • Department of Neurosurgery, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
  • Department of Neurosurgery, Asian Vivekananda Hospital, Moradabad, Uttar Pradesh, India
  • Department of Endocrinology, ABVIMS and Dr. RML Hospital, New Delhi, India
Venue
Indian Journal of Neurotrauma
Publisher
Georg Thieme Verlag KG
Published
2023-07-13
Volume
21
Issue
01
Pages
055-062
ISSN
  • 0973-0508
  • 2213-3739
DOI
10.1055/s-0043-1769802
Cited by
0
References
8
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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