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Flavonoids from Hypericum perforatum Show Antidepressant Activity in the Forced Swimming Test
Abstract
It has been shown recently that a flavonoid fraction (fraction II) obtained from a crude extract of Hypericum perforatum (St. John's Wort) was remarkably active in the forced swimming test (FST). Fraction II was further separated using MLCCC to give fractions IIa and IIb. Both fractions proved to be active in the FST at different dosages. Further separation of fraction IIa by preparative HPLC yielded fraction IIa1 which mainly was composed of hyperoside, isoquercitrin, miquelianin and quercitrin, and fraction IIa2 which contained small amounts of hyperoside and astilbin, while most compounds were not known. Both fractions were active after acute treatment in the FST. Isolates obtained from these fractions including hyperoside, isoquercitrin, quercitrin, miquelianin, the aglycone quercetin and astilbin, were tested for activity in the FST. Except for quercetin, quercitrin and astilbin all compounds were active. To exclude false positive results in the FST the validity was checked in open field experiments and in the FST after 12 days of daily treatment.
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Cited by
Synergy research: approaching a new generation of phytopharmaceuticals.
Wagner, H., & Ulrich-Merzenich, G. (2009) · Phytomedicine · doi:10.1016/j.phymed.2008.12.018 · Cited by 1,296
Kennedy, D. O., & Wightman, E. L. (2011) · Advances in Nutrition · doi:10.3945/an.110.000117 · Cited by 684
Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders
Zhang, Z.-J. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.014 · Cited by 344
Zhao, Z., Wang, W., Guo, H., & Zhou, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.030 · Cited by 187
Butterweck, V, Winterhoff, H., & Herkenham, M. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000937 · Cited by 91
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Metadata
- Authors
- Butterweck, V., Jürgenliemk, G., Nahrstedt, A., & Winterhoff, H.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2000-02
- Volume
- 66
- Issue
- 1
- Pages
- 3-6
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2053899138
- Cited by
- 362
- References
- 0
- FWCI
- 26.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Butterweck, V., Jürgenliemk, G., Nahrstedt, A., & Winterhoff, H. (2000). Flavonoids from Hypericum perforatum Show Antidepressant Activity in the Forced Swimming Test. Planta Medica. https://doi.org/10.1055/s-2000-11119
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