Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats
Abstract
Many flavonoids extracted from nature plants have been reported to exert antidepressant-like effect in animal studies. The present study was designed to observe the effects of liquiritin, a flavone compound derived from Glycyrrhiza uralensis, on the behaviors of chronic variable stress induced depression model rats and to explore the possible association between its antidepressant-like effect and antioxidative activity by measuring erythrocyte superoxide dismutase (SOD) activity and plasma malondialdehyde (MDA) level of the experimental animals. With the exposure to stressor once daily for consecutive 5 weeks, liquiritin and a positive control drug fluoxetine were administered via gastric intubation to rats once daily for consecutive 3 weeks from the 3rd week. The results showed that CVS reduced open-field activity and sucrose consumption significantly, but increased immobility time in forced swimming test. Treatment of liquiritin could effectively reverse alteration in immobility time and sucrose consumption but did not show significant effect on open-field activity. Moreover, liquiritin could increase SOD activity, inhibit lipid peroxidation, and lessen production of MDA, while fluoxetine did not. In conclusion, the present study demonstrated a potential antidepressant-like effect of liquiritin treatment on chronic variable stress induced depression model rats, which might be related to defense of liquiritin against oxidative stress.
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In rats displaying depressive-like behaviour induced by chronic mild stress, administration of liquiritin decreases immobility time, increases sucrose consumption, increases SOD activity, and attenuates MDA production in the peripheral blood.
“In rats displaying depressive-like behaviour induced by chronic mild stress, administration of liquiritin, an antioxidant derived from Glycyrrhiza uralensis, decreased immobility time, increased sucrose consumption, increased SOD activity, and attenuated MDA production in the peripheral blood [55].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [55]
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- Authors
- Zhao, Z., Wang, W., Guo, H., & Zhou, D.
- Affiliations
- Peking University (CN)
- Corresponding author
- Guo, Hongzhu
- Zhou, Dongfeng
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 194
- Issue
- 1
- Pages
- 108-113
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2093126939
- Cited by
- 187
- References
- 50
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 12 · 2022: 15 · 2021: 7 · 2020: 11 · 2019: 11 · 2018: 11 · 2017: 13 · 2016: 18 · 2015: 12 · 2014: 18 · 2013: 11 · 2012: 9
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Peking University Health Science Center
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Keywords
- liquiritin, Glycyrrhiza uralensis, antidepressant-like effects, chronic variable stress, depression model, oxidative stress, superoxide dismutase, malondialdehyde, lipid peroxidation, flavonoids, fluoxetine, forced swim test, sucrose intake
- MeSH terms
- Analysis of Variance, Animals, Antidepressive Agents, Behavior, Animal, Depression, Disease Models, Animal, Exploratory Behavior, Food Preferences, Glucosides, Male, Malondialdehyde, Phytotherapy, Plant Extracts, Random Allocation, Stress, Psychological, Superoxide Dismutase, Swimming, Time Factors, Rats, Sprague-Dawley, Glycyrrhiza uralensis, Flavanones, Rats
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