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HYPEREMESIS GRAVIDARUM: A CURRENT REVIEW
Abstract
Hyperemesis gravidarum or pernicious vomiting of pregnancy affects between 0.3% and 2% of all pregnant patients. The objective of this paper is to review current literature pertaining to epidemiology, etiology, symptomatology, complications, treatment, and perinatal outcome of patients with hyperemesis gravidarum. We performed a MEDLINE search of the English literature from 1966 through January 2000 utilizing the keywords: hyperemesis gravidarum, nausea and vomiting, and pregnancy. Current data pertaining to epidemiology, etiology, clinical manifestations, differential diagnosis, complications, various treatment modalities, subsequent perinatal outcome and recent developments are presented. Review of the literature supports that hyperemesis gravidarum is a multifactorial disease in which pregnancy-induced hormonal changes associated with concurrent gastrointestinal dysmotility and possible Helicobacter pylori infection function as contributing factors. Therapeutic key elements are mainly supportive in conjunction with antiemetic medication. It appears perinatal outcome is unaffected.
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Citations
Cited by
Nausea and Vomiting in Pregnancy
Niebyl, J. R. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1003896 · Cited by 340
Interventions for nausea and vomiting in early pregnancy
Matthews, A., Haas, D. M., O'Mathúna, D. P., & Dowswell, T. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007575.pub4 · Cited by 339
Nausea and vomiting of pregnancy and hyperemesis gravidarum
Fejzo, M. S., Trovik, J., Grooten, I. J., Sridharan, K., Roseboom, T. J., Vikanes, Å., Painter, R. C., & Mullin, P. M. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0110-3 · Cited by 306
Vandraas, K., Vikanes, Å., Vangen, S., Magnus, P., Støer, N., & Grjibovski, A. (2013) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12429 · Cited by 54
Metadata
- Authors
- Eliakim, R., Abulafia, O., & Sherer, D. M.
- Venue
- American Journal of Perinatology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2000
- Volume
- Volume 17
- Issue
- Number 04
- Pages
- 207-218
- ISSN
- 0735-1631 (ISSN-L)
- 1098-8785
- OpenAlex
- W1973874388
- Cited by
- 234
- References
- 0
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eliakim, R., Abulafia, O., & Sherer, D. M. (2000). HYPEREMESIS GRAVIDARUM: A CURRENT REVIEW. American Journal of Perinatology. https://doi.org/10.1055/s-2000-9424
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
